MedPath

Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients

Phase 4
Completed
Conditions
Pain
Interventions
First Posted Date
2012-06-19
Last Posted Date
2014-03-17
Lead Sponsor
University of California, San Francisco
Target Recruit Count
20
Registration Number
NCT01622296
Locations
🇺🇸

University of California, San Francisco, San Francisco, California, United States

The Effects of Different Clonidine Concentrations on Axillary Brachial Plexus Block With 1,5% Lidocaine

Phase 2
Completed
Conditions
Fascicular Block
Motor Activity
Pain, Postoperative
Latency Period
Interventions
First Posted Date
2012-06-15
Last Posted Date
2012-06-15
Lead Sponsor
Universidade Federal do Rio de Janeiro
Target Recruit Count
60
Registration Number
NCT01620112

A Randomized, Double-blind, Placebo- and Active-controlled Study of the Electric Current Effects of ABT-639 on the Spontaneous Activity of Pain Sensory Receptors in Patients With Diabetic Peripheral Neuropathy

Phase 2
Completed
Conditions
Diabetic Neuropathic Pain
Interventions
First Posted Date
2012-05-02
Last Posted Date
2013-01-03
Lead Sponsor
AbbVie (prior sponsor, Abbott)
Target Recruit Count
39
Registration Number
NCT01589432
Locations
🇬🇧

Site Reference ID/Investigator# 68882, London, United Kingdom

Intrauterine Lidocaine for Laminaria

Phase 1
Completed
Conditions
Abortion, Induced
Pain Management
Interventions
Drug: Normal Saline
Drug: Lidocaine
First Posted Date
2012-02-29
Last Posted Date
2014-05-14
Lead Sponsor
University of North Carolina, Chapel Hill
Target Recruit Count
72
Registration Number
NCT01541293
Locations
🇺🇸

University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States

Self-administered Intravaginal 2% Lidocaine Gel Prior to Intrauterine Device Insertion in Nulliparous Women

Not Applicable
Completed
Conditions
Pain
Interventions
Drug: Placebo
Drug: Lidocaine
First Posted Date
2012-02-16
Last Posted Date
2016-12-22
Lead Sponsor
University of Pittsburgh
Target Recruit Count
61
Registration Number
NCT01534520
Locations
🇺🇸

Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States

Brain Imaging of Lidoderm for Chronic Back Pain

Phase 4
Completed
Conditions
Low Back Pain
Interventions
Drug: lidocaine
Drug: placebo
First Posted Date
2012-01-24
Last Posted Date
2013-07-30
Lead Sponsor
Northwestern University
Target Recruit Count
38
Registration Number
NCT01515540
Locations
🇺🇸

Northwestern University, Chicago, Illinois, United States

Effect of Epidural Analgesia on the Parameter ANI During Childbirth

Not Applicable
Terminated
Conditions
Labor Pain
Interventions
First Posted Date
2012-01-06
Last Posted Date
2016-11-03
Lead Sponsor
Hopital Foch
Target Recruit Count
42
Registration Number
NCT01505283
Locations
🇫🇷

Hopital Foch, Suresnes, Ile de France, France

Effectiveness of Parent-Led Interventions in Reducing Infant Hypersensitivity to Pain

Phase 3
Conditions
Pain
Interventions
Behavioral: Educational Video - Sham
Behavioral: Educational video - Active
Drug: Sucrose Placebo (water)
Drug: Sucrose
Drug: Lidocaine Placebo
Drug: Lidocaine
First Posted Date
2012-01-02
Last Posted Date
2015-11-10
Lead Sponsor
The Hospital for Sick Children
Target Recruit Count
352
Registration Number
NCT01503060
Locations
🇨🇦

The Hospital for Sick Children, Toronto, Ontario, Canada

🇨🇦

Outpatient Clinic, Toronto, Ontario, Canada

Efficacy Study of Topical Application of Lidacaine Spray Prior to IUD Insertion

Phase 4
Conditions
Drug Usage
Interventions
Drug: Lidocaine
Drug: saline
First Posted Date
2011-12-21
Last Posted Date
2011-12-21
Lead Sponsor
Ain Shams University
Target Recruit Count
200
Registration Number
NCT01496105
Locations
🇪🇬

Ain shams university hospital, Cairo, Egypt

The Safety, Tolerability, PK and PD of GSK2339345 in Healthy Subjects

Phase 1
Completed
Conditions
Cough
Interventions
Drug: GSK2339345 (nebulised)
Drug: GSK2339345 (solution)
Drug: Placebo (0.9% sodium chloride solution)
Drug: Lidocaine
First Posted Date
2011-12-19
Last Posted Date
2017-06-20
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
31
Registration Number
NCT01494636
Locations
🇬🇧

GSK Investigational Site, Manchester, United Kingdom

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