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Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Comparison of Two Lidocaine Administration Techniques

Phase 4
Completed
Conditions
Pain
Interventions
First Posted Date
2011-04-06
Last Posted Date
2018-07-26
Lead Sponsor
University of Chicago
Target Recruit Count
481
Registration Number
NCT01330134
Locations
🇺🇸

The University of Chicago Medical Center, Chicago, Illinois, United States

Lidocaine 5% Plasters (Versatis® 5%) in Pediatric Neuropathic Pains and Vasoocclusive Sickle Cell Crisis Pains

Phase 2
Completed
Conditions
Neuropathic Pains
Vasoocclusive Sickle Cell Crises Pains
Interventions
First Posted Date
2011-03-14
Last Posted Date
2014-10-30
Lead Sponsor
Centre Leon Berard
Target Recruit Count
39
Registration Number
NCT01314300
Locations
🇫🇷

Centre Médico-chirurgical de Réadaptation des Massues, Lyon, France

🇫🇷

IHOP, Lyon, France

The Impact of Pain Scores on Intrauterine Lidocaine Versus Normal Saline Infusion at the Time of IUD Placement

Phase 4
Completed
Conditions
Pain
Interventions
Drug: Normal Saline
Drug: Lidocaine
First Posted Date
2011-03-09
Last Posted Date
2014-02-05
Lead Sponsor
Women's Health Care Clinic, Torrance, California
Target Recruit Count
40
Registration Number
NCT01311102
Locations
🇺🇸

Women's Health Care Clinic, Torrance, California, United States

Clinical Study to Evaluate the Effect of pH on Pain Upon Local Anesthetic Administration.

Not Applicable
Terminated
Conditions
Local Anesthetics
Interventions
First Posted Date
2011-02-25
Last Posted Date
2017-04-11
Lead Sponsor
Massachusetts General Hospital
Target Recruit Count
29
Registration Number
NCT01304082
Locations
🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

A Trial Assessing The Association Between Type Of Local Anesthesia Treatment And Postoperative Pain In Patients In Having Undergone Arrhythmia Surgery

Not Applicable
Completed
Conditions
Post-operative Pain
Interventions
First Posted Date
2011-02-21
Last Posted Date
2019-07-10
Lead Sponsor
Baylor Research Institute
Target Recruit Count
300
Registration Number
NCT01300377
Locations
🇺🇸

Baylor Jack and Jane Heart and Vascular Institute, Dallas, Texas, United States

A Study to Characterize the Phenotype in Patients With Morton's Neuroma and to Explore the Effect of Local Administration of Xylocaine (Lidocaine)

Early Phase 1
Completed
Conditions
Morton's Neuroma
Interventions
Drug: Xylocaine
Drug: Placebo
First Posted Date
2011-02-17
Last Posted Date
2012-05-22
Lead Sponsor
AstraZeneca
Target Recruit Count
27
Registration Number
NCT01298310
Locations
🇸🇪

Research Site, Stockholm, Sweden

Lidocaine and Outpatient Gynecologic Laparoscopy

Not Applicable
Completed
Conditions
Pain
Interventions
Drug: Placebo
Drug: Lidocaine
First Posted Date
2010-11-30
Last Posted Date
2014-06-26
Lead Sponsor
Northwestern University
Target Recruit Count
70
Registration Number
NCT01250002
Locations
🇺🇸

Prentice Womens Hospital, Chicago, Illinois, United States

Spinal Anaesthesia for Knee Arthroscopy: Does Lignocaine Shorten the Effect of Bupivacaine

Phase 4
Completed
Conditions
Spinal Anesthesia
Interventions
First Posted Date
2010-11-23
Last Posted Date
2015-05-08
Lead Sponsor
Frederikssunds Hospital, Denmark
Target Recruit Count
60
Registration Number
NCT01245868
Locations
🇩🇰

Dep. of anesthesiology, Hospital of Frederikssund, Frederikssund, Denmark

🇩🇰

Jon Jacobsen, Frederikssund, Denmark

Determine the Effect of AZD3161,Injected Intradermally, on Quantitative Sensory Testing Variables in Normal and Ultraviolet-C (UVC) Exposed Skin in Healthy Volunteers

Phase 1
Completed
Conditions
Peripheral Neuropathic Pain
Nociceptive Pain
Interventions
Drug: AZD3161
Drug: AZD3161 Placebo
Drug: Lidocaine
First Posted Date
2010-11-15
Last Posted Date
2011-04-12
Lead Sponsor
AstraZeneca
Target Recruit Count
26
Registration Number
NCT01240148
Locations
🇬🇧

Research Site, London, United Kingdom

Use of Lidocaine in Rapid Sequence Induction

Not Applicable
Completed
Conditions
Hemodynamic Response
Interventions
Drug: Placebo
Drug: Lidocaine
First Posted Date
2010-11-11
Last Posted Date
2011-08-24
Lead Sponsor
University of Athens
Target Recruit Count
76
Registration Number
NCT01238718
Locations
🇬🇷

Aretaieio Hospital, University of Athens, Athens, Attiki, Greece

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