MedPath

Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Effect of Lidocaine and Esmolol to Improve the Quality of Recovery

Phase 4
Terminated
Conditions
Pain
Vomiting
Constipation
Nausea
Interventions
First Posted Date
2010-05-03
Last Posted Date
2016-11-03
Lead Sponsor
Cedars-Sinai Medical Center
Target Recruit Count
32
Registration Number
NCT01114997
Locations
🇺🇸

Cedars Sinai Medical Center, Los Angeles, California, United States

Treatment of Postoperative Pain After Total Hip Arthroplasty Using Intravenous Lidocaine Infusion

Phase 1
Withdrawn
Conditions
Postoperative Pain Management After Total Hip Arthroplasty
Interventions
Other: Normal Saline
Drug: Lidocaine
First Posted Date
2010-04-22
Last Posted Date
2015-04-06
Lead Sponsor
Loma Linda University
Registration Number
NCT01108562

Safety and Efficacy Study of KAI-1678 to Treat Pain in Subjects With Postherpetic Neuralgia

Phase 2
Completed
Conditions
Postherpetic Neuralgia
Interventions
First Posted Date
2010-04-20
Last Posted Date
2011-09-01
Lead Sponsor
KAI Pharmaceuticals
Target Recruit Count
23
Registration Number
NCT01106716

Local Anesthetic Continuous Preperitoneal Infiltration and Wound Hyperalgesia

First Posted Date
2010-03-01
Last Posted Date
2014-01-22
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
95
Registration Number
NCT01077752
Locations
🇫🇷

Departement d'Anesthesie-Reanimation, Hopital Saint-Antoine, Paris, France

Using Lignocaine Spray and Gel to Reduce the Pain Associated With Nasogastric Tube Insertion in Children

Not Applicable
Terminated
Conditions
Intubation; Difficult
Interventions
Drug: Placebo
Drug: Lignocaine
First Posted Date
2010-02-25
Last Posted Date
2016-03-31
Lead Sponsor
The University of Queensland
Target Recruit Count
13
Registration Number
NCT01075789
Locations
🇦🇺

Queensland Children's Medical Research Institute, Brisbane, Queensland, Australia

Treatment of Chronic Thoracic and Neck and Upper Extremity Pain

Phase 4
Completed
Conditions
Back Pain
Neck Pain
Interventions
First Posted Date
2010-02-19
Last Posted Date
2017-04-27
Lead Sponsor
Pain Management Center of Paducah
Target Recruit Count
120
Registration Number
NCT01071369
Locations
🇺🇸

Ambulatory Surgery Center, Paducah, Kentucky, United States

Intravenous Lidocaine for Laparoscopic Cholecystectomy

Not Applicable
Completed
Conditions
Postoperative Pain
Opioid Consumption
Interventions
First Posted Date
2010-02-04
Last Posted Date
2011-01-13
Lead Sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Target Recruit Count
80
Registration Number
NCT01062906
Locations
🇨🇦

McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada

Bupivacaine Versus Lidocaine on Inflammatory Regulation

Phase 4
Completed
Conditions
Pain
Interventions
First Posted Date
2010-02-02
Last Posted Date
2018-05-31
Lead Sponsor
University of Maryland
Target Recruit Count
11
Registration Number
NCT01060774
Locations
🇺🇸

University of Maryland, Baltimore College of Dental Surgery, Baltimore, Maryland, United States

Botulism Toxin Injection as a Treatment for Arthritis of the Basal Thumb Joint

Phase 4
Terminated
Conditions
Arthritis Multiple Joint
Interventions
First Posted Date
2010-01-11
Last Posted Date
2017-10-06
Lead Sponsor
University of Missouri-Columbia
Target Recruit Count
8
Registration Number
NCT01045694
Locations
🇺🇸

University of Missouri, Columbia, Missouri, United States

Efficacy of Remifentanil Compared to Lidocaine on the Incidence of Coughing During Emergence of Anesthesia

Not Applicable
Completed
Conditions
Cough
Anesthesia
Extubation
Interventions
First Posted Date
2009-12-04
Last Posted Date
2010-07-14
Lead Sponsor
Centre hospitalier de l'Université de Montréal (CHUM)
Target Recruit Count
93
Registration Number
NCT01026129
Locations
🇨🇦

Centre Hospitalier de l'Université de Montréal-Hôpital Notre-Dame, Montreal, Quebec, Canada

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