Methadone
- Generic Name
- Methadone
- Brand Names
- Diskets, Dolophine, Metadol, Metadol-D, Methadose
- Drug Type
- Small Molecule
- Chemical Formula
- C21H27NO
- CAS Number
- 76-99-3
- Unique Ingredient Identifier
- UC6VBE7V1Z
- Background
Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a number of uniqu...
- Indication
Methadone is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatment options are inadequate. It's recommended that use is reserved for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwis...
- Associated Conditions
- Opioid Addiction, Severe Pain
- Associated Therapies
- Opioid Detoxification, Maintenance therapy
IV Methadone Vs EXPAREL Erector Spinae Plane Blockade in Pediatric Subjects Undergoing Idiopathic Scoliosis Correction
- Conditions
- Interventions
- First Posted Date
- 2023-02-16
- Last Posted Date
- 2024-10-04
- Lead Sponsor
- Dr. Casey Stondell, MD
- Target Recruit Count
- 30
- Registration Number
- NCT05730920
- Locations
- 🇺🇸
Shriners Hospitals for Children, Sacramento, California, United States
Intraoperative Methadone for Postoperative Pain in Patients Undergoing Tonsillectomy
- First Posted Date
- 2022-07-06
- Last Posted Date
- 2023-12-05
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 130
- Registration Number
- NCT05445856
- Locations
- 🇩🇰
Department of Anaesthesiology and Intensive Care, Randers, Denmark
Understanding How Methadone Treatment During Surgery Affects Pain Levels and the Need for Pain Medications After Surgery
- First Posted Date
- 2022-06-14
- Last Posted Date
- 2024-05-13
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Target Recruit Count
- 210
- Registration Number
- NCT05417100
- Locations
- 🇺🇸
Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York, New York, United States
Methadone for 'Adenocarcinopathic' Pain Treatment
- First Posted Date
- 2022-04-13
- Last Posted Date
- 2022-12-05
- Lead Sponsor
- Ottawa Hospital Research Institute
- Registration Number
- NCT05325164
Real-life Observational Study of Cancer Pain Management With Methadone
- Conditions
- First Posted Date
- 2022-03-03
- Last Posted Date
- 2024-10-31
- Lead Sponsor
- Laboratoires Bouchara-Recordati
- Target Recruit Count
- 136
- Registration Number
- NCT05265442
- Locations
- 🇫🇷
LBR, Puteaux, France
Study of LYN-014 in Individuals With Opioid Use Disorder Who Are Stable on Methadone Therapy
- Conditions
- Interventions
- First Posted Date
- 2022-02-22
- Last Posted Date
- 2023-01-19
- Lead Sponsor
- Lyndra Inc.
- Registration Number
- NCT05251376
Pediatric Pain Optimization After Tonsillectomy
- Conditions
- Interventions
- First Posted Date
- 2022-02-17
- Last Posted Date
- 2024-10-17
- Lead Sponsor
- Duke University
- Target Recruit Count
- 66
- Registration Number
- NCT05244226
- Locations
- 🇺🇸
Duke University School of Medicine, Durham, North Carolina, United States
Extended-release Pharmacotherapy for Opioid Use Disorder
- Conditions
- Interventions
- First Posted Date
- 2021-12-20
- Last Posted Date
- 2024-01-19
- Lead Sponsor
- King's College London
- Target Recruit Count
- 342
- Registration Number
- NCT05164549
- Locations
- 🇬🇧
South London and Maudsley NHS Foundation Trust, London, United Kingdom
🇬🇧NHS Tayside, Dundee, United Kingdom
🇬🇧Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom
Pharmacokinetics of Methadone in Adults Undergoing Cardiac Surgery With Extracorporeal Circulation
- Conditions
- Interventions
- First Posted Date
- 2021-10-12
- Last Posted Date
- 2021-10-12
- Lead Sponsor
- Pontificia Universidad Catolica de Chile
- Target Recruit Count
- 30
- Registration Number
- NCT05075265
Methadone Anesthesia For Kidney Transplant Receptors
- First Posted Date
- 2021-06-01
- Last Posted Date
- 2021-06-01
- Lead Sponsor
- University of Sao Paulo General Hospital
- Target Recruit Count
- 32
- Registration Number
- NCT04908345
- Locations
- 🇧🇷
Hospital das Clínicas da FMUSP, Sao Paulo, SP, Brazil
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.