Methadone
- Generic Name
- Methadone
- Brand Names
- Diskets, Dolophine, Metadol, Metadol-D, Methadose
- Drug Type
- Small Molecule
- Chemical Formula
- C21H27NO
- CAS Number
- 76-99-3
- Unique Ingredient Identifier
- UC6VBE7V1Z
- Background
Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a number of uniqu...
- Indication
Methadone is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatment options are inadequate. It's recommended that use is reserved for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwis...
- Associated Conditions
- Opioid Addiction, Severe Pain
- Associated Therapies
- Opioid Detoxification, Maintenance therapy
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery
- First Posted Date
- 2019-03-28
- Last Posted Date
- 2019-09-13
- Lead Sponsor
- NorthShore University HealthSystem
- Target Recruit Count
- 140
- Registration Number
- NCT03893734
- Locations
- 🇺🇸
NorthShore University HealthSystem, Evanston, Illinois, United States
Methadone for Emergence Delirium in Children Undergoing Outpatient Strabismus Surgery
- First Posted Date
- 2018-12-19
- Last Posted Date
- 2022-07-19
- Lead Sponsor
- Ochsner Health System
- Target Recruit Count
- 55
- Registration Number
- NCT03778372
- Locations
- 🇺🇸
Ochsner Main Campus, Jefferson, Louisiana, United States
Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)
- Conditions
- Interventions
- First Posted Date
- 2018-10-31
- Last Posted Date
- 2024-02-02
- Lead Sponsor
- Duke University
- Target Recruit Count
- 907
- Registration Number
- NCT03726268
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
Gabapentin, Methadone, and Oxycodone With or Without Venlafaxine Hydrochloride in Managing Pain in Participants With Stage II-IV Squamous Cell Head and Neck Cancer Undergoing Chemoradiation Therapy
- Conditions
- Interventions
- First Posted Date
- 2018-07-02
- Last Posted Date
- 2021-12-09
- Lead Sponsor
- Roswell Park Cancer Institute
- Target Recruit Count
- 62
- Registration Number
- NCT03574792
- Locations
- 🇺🇸
Roswell Park Cancer Institute, Buffalo, New York, United States
Preoperative Methadone Single Dose Reduces Postoperative Morphine Consumption.
- First Posted Date
- 2018-05-18
- Last Posted Date
- 2018-07-03
- Lead Sponsor
- Kantonsspital Baden
- Target Recruit Count
- 160
- Registration Number
- NCT03529032
- Locations
- 🇨🇭
Kantonsspital Baden, Baden, Kanton Aargau, Switzerland
Methadone Associated With Morphine for Cancer Pain
- First Posted Date
- 2017-10-30
- Last Posted Date
- 2017-10-30
- Lead Sponsor
- Federal University of São Paulo
- Target Recruit Count
- 40
- Registration Number
- NCT03324815
- Locations
- 🇧🇷
Rioko K Sakata, São Paulo, Brazil
Methadone and Quality of Postoperative Recovery
- First Posted Date
- 2017-05-30
- Last Posted Date
- 2020-08-24
- Lead Sponsor
- NorthShore University HealthSystem
- Target Recruit Count
- 130
- Registration Number
- NCT03168958
- Locations
- 🇺🇸
NorthShore University HealthSystem, Evanston, Illinois, United States
Methadone Demonstration Project With Neonatal Intensive Care Unit Infants Diagnosed With Neonatal Abstinence Syndrome
- First Posted Date
- 2017-05-01
- Last Posted Date
- 2023-07-03
- Lead Sponsor
- Johns Hopkins All Children's Hospital
- Target Recruit Count
- 11
- Registration Number
- NCT03134703
- Locations
- 🇺🇸
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida, United States
Opioid Dependence Treatment Therapies in Pregnancy
- Conditions
- Interventions
- First Posted Date
- 2017-03-31
- Last Posted Date
- 2020-11-09
- Lead Sponsor
- University of Pittsburgh
- Target Recruit Count
- 55
- Registration Number
- NCT03098407
- Locations
- 🇺🇸
Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States
Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings
- Conditions
- Interventions
- First Posted Date
- 2017-03-24
- Last Posted Date
- 2024-10-04
- Lead Sponsor
- Yale University
- Target Recruit Count
- 1702
- Registration Number
- NCT03089983
- Locations
- 🇲🇾
Kajang Prison, Kajang, Selangor, Malaysia
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.