Naltrexone
- Generic Name
- Naltrexone
- Brand Names
- Contrave, Embeda, Vivitrol
- Drug Type
- Small Molecule
- Chemical Formula
- C20H23NO4
- CAS Number
- 16590-41-3
- Unique Ingredient Identifier
- 5S6W795CQM
- Background
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
- Indication
Used as an adjunct to a medically supervised behaviour modification program in the maintenance of opiate cessation in individuals who were formerly physically dependent on opiates and who have successfully undergone detoxification. Also used for the management of alcohol dependence in conjunction with a behavioural modification program.
- Associated Conditions
- Alcohol Dependency, Cholestatic pruritus, Obesity, Opioid Dependence, Severe Pain
- Associated Therapies
- -
Trial for the Treatment of Alcohol Dependence
- Conditions
- First Posted Date
- 2005-07-18
- Last Posted Date
- 2005-07-18
- Lead Sponsor
- University of Sydney
- Target Recruit Count
- 200
- Registration Number
- NCT00120601
- Locations
- 🇦🇺
Drug Health Services, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
Managing Alcoholism in People Who Do Not Respond to Naltrexone
- First Posted Date
- 2005-06-21
- Last Posted Date
- 2019-09-18
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 302
- Registration Number
- NCT00115037
- Locations
- 🇺🇸
University of Pennsylvania Treatment Research Center, Chestnut Street, Philadelphia, Pennsylvania, United States
Targeted Interventions for Weight-Concerned Smokers
- Conditions
- Interventions
- First Posted Date
- 2005-03-15
- Last Posted Date
- 2013-03-05
- Lead Sponsor
- Yale University
- Target Recruit Count
- 172
- Registration Number
- NCT00105482
- Locations
- 🇺🇸
Yale University School of Medicine Substance Abuse Treatment Unit, New Haven, Connecticut, United States
Drug Treatment for Pathologic Gambling Disorder
- First Posted Date
- 2003-02-05
- Last Posted Date
- 2023-02-23
- Lead Sponsor
- University of Chicago
- Target Recruit Count
- 83
- Registration Number
- NCT00053677
- Locations
- 🇺🇸
University of Minnesota Medical School, Minneapolis, Minnesota, United States
Treating Alcohol Use In Older Adults With Depression
- First Posted Date
- 2001-07-05
- Last Posted Date
- 2009-09-23
- Lead Sponsor
- US Department of Veterans Affairs
- Target Recruit Count
- 74
- Registration Number
- NCT00018824
- Locations
- 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Naltrexone in Treatment of Cocaine Dependence - 5
- Conditions
- First Posted Date
- 2001-04-18
- Last Posted Date
- 2017-01-16
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Registration Number
- NCT00015080
- Locations
- 🇺🇸
Cincinnati MDRU, Cincinnati, Ohio, United States
Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone)
- Conditions
- Interventions
- First Posted Date
- 2000-11-09
- Last Posted Date
- 2017-04-21
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 165
- Registration Number
- NCT00006489
- Locations
- 🇺🇸
Center for Anxiety, University of Pennsylvania, Philadelphia, Pennsylvania, United States
Naltrexone for Early Problem Drinkers
- Conditions
- First Posted Date
- 1999-11-03
- Last Posted Date
- 2011-06-20
- Lead Sponsor
- UConn Health
- Target Recruit Count
- 160
- Registration Number
- NCT00000455
- Locations
- 🇺🇸
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States
Naltrexone Treatment for Alcoholic Women
- First Posted Date
- 1999-11-03
- Last Posted Date
- 2014-05-07
- Lead Sponsor
- Yale University
- Target Recruit Count
- 160
- Registration Number
- NCT00000448
- Locations
- 🇺🇸
Substance Abuse Treatment Unit, Yale University, New Haven, Connecticut, United States
Drug Therapy for Alcohol Dependence in Alaska Natives (Naltrexone/Sertraline)
- First Posted Date
- 1999-11-03
- Last Posted Date
- 2013-01-29
- Lead Sponsor
- Yale University
- Target Recruit Count
- 198
- Registration Number
- NCT00000451
Drug Development Updates
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