Tacrolimus
- Generic Name
- Tacrolimus
- Brand Names
- Advagraf, Astagraf, Envarsus, Modigraf, Prograf, Protopic, Tacforius
- Drug Type
- Small Molecule
- Chemical Formula
- C44H69NO12
- CAS Number
- 104987-11-3
- Unique Ingredient Identifier
- Y5L2157C4J
- Background
Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condi...
- Indication
Immediate-release formulations of tacrolimus are indicated for the prophylaxis of organ rejection in adult and pediatric patients receiving allogeneic liver, kidney, heart, or lung transplants, in combination with other immunosuppressants. Extended-release formulations of tacrolimus are indicated for the prophylaxis of organ rejection in adult and pediatric ...
- Associated Conditions
- Graft-versus-host Disease (GVHD), Heart Transplant Rejection, Kidney Transplant Rejection, Liver Transplant Rejection, Lung Transplant Rejection, Oral Lichen Planus, Psoriasis, Pyoderma Gangrenosum, Rheumatoid Arthritis, Severe Atopic Dermatitis, Vitiligo, Moderate Atopic dermatitis
- Associated Therapies
- -
Comparing Efficacy & Safety of Tacrolimus & MMF With/Without Induction in the Elderly Following Kidney Transplantation.
- First Posted Date
- 2006-02-27
- Last Posted Date
- 2014-09-01
- Lead Sponsor
- Astellas Pharma Inc
- Target Recruit Count
- 267
- Registration Number
- NCT00296309
Comparing Efficacy and Safety of Tacrolimus With Steroids or Monoclonal Anti-IL2R Antibody in Hepatitis C Virus (HCV) Positive Liver Transplant Patients
- Conditions
- Interventions
- First Posted Date
- 2006-02-24
- Last Posted Date
- 2013-04-11
- Lead Sponsor
- Astellas Pharma Inc
- Target Recruit Count
- 138
- Registration Number
- NCT00295607
Immunosuppression Impact on the Metabolic Control of Kidney Transplant With Pre-Existing Type 2 Diabetes (DM)
- Conditions
- Interventions
- First Posted Date
- 2006-02-24
- Last Posted Date
- 2017-10-06
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 29
- Registration Number
- NCT00296296
- Locations
- 🇺🇸
Stanford university Hospital and Clinics, Stanford, California, United States
Steroid Free Immunosuppression in Liver Transplantation
- Conditions
- Interventions
- First Posted Date
- 2006-02-24
- Last Posted Date
- 2012-11-19
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 40
- Registration Number
- NCT00296244
- Locations
- 🇺🇸
Thomas Jefferson University, Philadelphia, Pennsylvania, United States
Donor Stem Cell Transplant in Treating Older or Frail Patients With Hematologic Cancer
- Conditions
- Interventions
- Biological: anti-thymocyte globulinBiological: filgrastimBiological: therapeutic allogeneic lymphocytesDrug: busulfanDrug: fludarabine phosphateDrug: methotrexateDrug: tacrolimusProcedure: nonmyeloablative allogeneic hematopoietic stem cell transplantationProcedure: peripheral blood stem cell transplantation
- First Posted Date
- 2006-02-24
- Last Posted Date
- 2012-10-04
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 25
- Registration Number
- NCT00296023
- Locations
- 🇺🇸
Alta Bates Comprehensive Cancer Center, Berkeley, California, United States
🇺🇸UCSF Comprehensive Cancer Center, San Francisco, California, United States
Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer, Metastatic Kidney Cancer, or Aplastic Anemia
- First Posted Date
- 2006-02-24
- Last Posted Date
- 2014-01-06
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 35
- Registration Number
- NCT00295997
- Locations
- 🇺🇸
UCSF Comprehensive Cancer Center, San Francisco, California, United States
🇺🇸Wake Forest University Comprehensive Cancer Center, Winston-Salem, North Carolina, United States
Comparing Efficacy & Safety of Tacrolimus With/Without MMF or Monoclonal Anti-IL2R Antibody in Liver Transplantation.
- First Posted Date
- 2006-02-24
- Last Posted Date
- 2014-08-26
- Lead Sponsor
- Astellas Pharma Inc
- Target Recruit Count
- 627
- Registration Number
- NCT00295594
A Study to Assess the Safety and Effectiveness of Tacrolimus Cream in the Treatment of Psoriasis
- Conditions
- First Posted Date
- 2006-02-20
- Last Posted Date
- 2007-12-24
- Lead Sponsor
- Astellas Pharma Inc
- Target Recruit Count
- 645
- Registration Number
- NCT00293930
Renal Function Optimization With Mycophenolate Mofetil (MMF) Immunosuppressor Regimes (ALHAMBRA)
- Conditions
- First Posted Date
- 2006-02-10
- Last Posted Date
- 2007-05-15
- Target Recruit Count
- 94
- Registration Number
- NCT00290069
- Locations
- 🇪🇸
Hospital Universitario Marqués de Valdecilla, Santander, Spain
🇪🇸Hospital Universitario Ramón y Cajal, Madrid, Spain
🇪🇸Hospital General Universitario Gregorio Marañón, Madrid, Spain
Randomized Controlled Trial in Liver Transplant Recipients Treated in Steroid Sparing Regimen
- Conditions
- First Posted Date
- 2006-02-06
- Last Posted Date
- 2014-09-22
- Lead Sponsor
- Duke University
- Target Recruit Count
- 40
- Registration Number
- NCT00286871
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
Drug Development Updates
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