Tacrolimus
- Generic Name
- Tacrolimus
- Brand Names
- Advagraf, Astagraf, Envarsus, Modigraf, Prograf, Protopic, Tacforius
- Drug Type
- Small Molecule
- Chemical Formula
- C44H69NO12
- CAS Number
- 104987-11-3
- Unique Ingredient Identifier
- Y5L2157C4J
- Background
Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condi...
- Indication
Immediate-release formulations of tacrolimus are indicated for the prophylaxis of organ rejection in adult and pediatric patients receiving allogeneic liver, kidney, heart, or lung transplants, in combination with other immunosuppressants. Extended-release formulations of tacrolimus are indicated for the prophylaxis of organ rejection in adult and pediatric ...
- Associated Conditions
- Graft-versus-host Disease (GVHD), Heart Transplant Rejection, Kidney Transplant Rejection, Liver Transplant Rejection, Lung Transplant Rejection, Oral Lichen Planus, Psoriasis, Pyoderma Gangrenosum, Rheumatoid Arthritis, Severe Atopic Dermatitis, Vitiligo, Moderate Atopic dermatitis
- Associated Therapies
- -
Enteric-coated Mycophenolate Sodium (EC-MPS) With Reduced-dose Tacrolimus Versus EC-MPS With Standard-dose Tacrolimus in Stable Kidney Transplant Recipients
- Conditions
- Interventions
- First Posted Date
- 2006-02-01
- Last Posted Date
- 2011-05-02
- Lead Sponsor
- Novartis
- Target Recruit Count
- 94
- Registration Number
- NCT00284934
- Locations
- 🇨🇭
Novartis, Basel, Switzerland
A Study to Assess the Pharmacokinetics of a Modified-release Tacrolimus Based Immunosuppression Regimen in Stable Kidney Transplant Patients
- Conditions
- Interventions
- First Posted Date
- 2006-01-27
- Last Posted Date
- 2013-09-26
- Lead Sponsor
- Astellas Pharma Inc
- Target Recruit Count
- 70
- Registration Number
- NCT00282568
A Study to Assess the Pharmacokinetics of a Modified-release Tacrolimus Based Immunosuppression Regimen in Stable Liver Transplant Patients
- Conditions
- Interventions
- First Posted Date
- 2006-01-26
- Last Posted Date
- 2013-09-30
- Lead Sponsor
- Astellas Pharma Inc
- Target Recruit Count
- 70
- Registration Number
- NCT00282243
A Study of a Modified-Release Tacrolimus Based Immunosuppression Regimen in Stable Pediatric Liver Transplant Patients
- Conditions
- Interventions
- First Posted Date
- 2006-01-26
- Last Posted Date
- 2013-10-17
- Lead Sponsor
- Astellas Pharma Inc
- Target Recruit Count
- 19
- Registration Number
- NCT00282256
Tacrolimus and Sirolimus as Prophylaxis After Allogenic Non-myeloablative Peripheral Blood Stem Cell Transplantation
- Conditions
- First Posted Date
- 2006-01-26
- Last Posted Date
- 2014-05-12
- Lead Sponsor
- Dana-Farber Cancer Institute
- Target Recruit Count
- 31
- Registration Number
- NCT00282282
- Locations
- 🇺🇸
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Donor Stem Cell Transplant or Donor White Blood Cell Infusions in Treating Patients With Hematologic Cancer
- Conditions
- Interventions
- Biological: filgrastimBiological: anti-thymocyte globulinDrug: cyclophosphamideDrug: busulfanDrug: carmustineDrug: cyclosporineDrug: fludarabine phosphateDrug: methotrexateDrug: cytarabineDrug: mycophenolate mofetilDrug: etoposideDrug: methylprednisoloneDrug: tacrolimusDrug: melphalanProcedure: peripheral blood stem cell transplantationRadiation: radiation therapyProcedure: umbilical cord blood transplantation
- First Posted Date
- 2006-01-25
- Last Posted Date
- 2017-09-27
- Lead Sponsor
- OHSU Knight Cancer Institute
- Target Recruit Count
- 200
- Registration Number
- NCT00281879
- Locations
- 🇺🇸
OHSU Knight Cancer Institute, Portland, Oregon, United States
Hematopoietic Stem Cell Support in Vasculitis
- First Posted Date
- 2006-01-18
- Last Posted Date
- 2018-08-02
- Lead Sponsor
- Northwestern University
- Target Recruit Count
- 7
- Registration Number
- NCT00278512
- Locations
- 🇺🇸
Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States
The Comparison of Tacrolimus and Sirolimus Immunosuppression Based Drug Regimens in Kidney Transplant Recipients
- Conditions
- Interventions
- First Posted Date
- 2006-01-12
- Last Posted Date
- 2011-12-08
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 165
- Registration Number
- NCT00275535
- Locations
- 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States
Induction Therapy Study in Live Donor Kidney Transplant Recipients With a Positive Crossmatch
- First Posted Date
- 2006-01-12
- Last Posted Date
- 2018-01-18
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 56
- Registration Number
- NCT00275509
- Locations
- 🇺🇸
The Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States
Study of ISA247 (Voclosporin) in De Novo Renal Transplantation
- First Posted Date
- 2005-12-28
- Last Posted Date
- 2013-02-12
- Lead Sponsor
- Aurinia Pharmaceuticals Inc.
- Target Recruit Count
- 334
- Registration Number
- NCT00270634
- Locations
- 🇨🇦
Isotechnika Investigational Site, Saskatoon, Saskatchewan, Canada
Drug Development Updates
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