Pseudoephedrine
- Generic Name
- Pseudoephedrine
- Brand Names
- Advil Cold and Sinus, Alavert D, Aleve-D, Allegra-D, Aller-tec D, Allerclear, Bromfed DM, Cheratussin Dac, Clarinex-D, Claritin-D, Codar D, Covan, Entex T, Lodrane D, Mar-cof BP, Mucinex D, Nexafed, Pseudodine C, Rescon Tablets, Semprex-D, Stahist Ad Liquid, Sudafed, Sudafed Sinus & Pain, Sudogest, Triacin-C, Tusnel C, Wal Zyr D, Wal-act, Wal-itin D, Wal-phed, Zephrex-D, Zyrtec-D
- Drug Type
- Small Molecule
- Chemical Formula
- C10H15NO
- CAS Number
- 90-82-4
- Unique Ingredient Identifier
- 7CUC9DDI9F
- Background
Pseudoephedrine is structurally related to ephedrine but exerts a weaker effect on the sympathetic nervous system. Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseudoephedrine was described in dogs in 1927.
- Indication
Pseudoephedrine is a sympathomimetic amine used for its decongestant activity.
- Associated Conditions
- Allergic Reaction, Allergic Rhinitis (AR), Common Cold, Common Cold Associated With Cough, Cough, Cough caused by Common Cold, Eye allergy, Fever, Flu caused by Influenza, Headache, Irritative cough, Nasal Allergies, Nasal Congestion, Nasal Congestion caused by Common Cold, Pain, Perennial Allergy, Priapism, Respiratory Allergy, Rhinorrhoea, Seasonal Allergic Rhinitis, Seasonal Allergies, Sinus Congestion, Sinusitis, Sneezing, Sore Throat, Symptoms of Acute Bronchitis Accompanied by Coughing, Throat irritation, Upper Respiratory Tract Infection, Upper respiratory tract congestion, Upper respiratory tract signs and symptoms, Cold or flu syndrome, Dry cough, Minor aches and pains, Sinus pain, Watery itchy eyes
- Associated Therapies
- Airway secretion clearance therapy
An Efficacy Study of JNJ-39220675 and Pseudoephedrine in Participants With Allergic Rhinitis
- Conditions
- Interventions
- First Posted Date
- 2008-12-09
- Last Posted Date
- 2013-10-30
- Target Recruit Count
- 53
- Registration Number
- NCT00804687
The Effect of Pseudoephedrine on Rhinitis and Sleep
- First Posted Date
- 2008-06-25
- Last Posted Date
- 2017-10-18
- Lead Sponsor
- Milton S. Hershey Medical Center
- Target Recruit Count
- 34
- Registration Number
- NCT00704496
- Locations
- 🇺🇸
Penn State College of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States
Study of the Effect of SCH 900538 on Congestion in Subjects With Seasonal Allergic Rhinitis (Study P05031)(COMPLETED)
- Conditions
- Interventions
- First Posted Date
- 2008-05-07
- Last Posted Date
- 2015-11-01
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 265
- Registration Number
- NCT00673062
A Study To Investigate If MRI Scanning Is Effective At Seeing What Hayfever Drugs Do In Nasal Passage.
- Conditions
- First Posted Date
- 2007-08-17
- Last Posted Date
- 2013-09-02
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 21
- Registration Number
- NCT00517946
- Locations
- 🇬🇧
GSK Investigational Site, London, United Kingdom
Study to Assess the Effect of a Combination of Cetirizine With Pseudoephedrine Versus Cetirizine Alone on Symptoms in Patients With Allergic Rhinitis
- Conditions
- First Posted Date
- 2006-06-08
- Last Posted Date
- 2010-02-03
- Target Recruit Count
- 51
- Registration Number
- NCT00334698
- Locations
- 🇩🇪
Fraunhofer-Institute of Toxicology and Experimental Medicine, Hannover, Germany
The Effects of Phenylephrine Compared With Those of Placebo and Pseudoephedrine on Nasal Congestion in Subjects With Seasonal Allergic Rhinitis (SAR)(P04579)
- Conditions
- Interventions
- First Posted Date
- 2006-01-12
- Last Posted Date
- 2022-02-09
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 39
- Registration Number
- NCT00276016
Treatment of Orthostatic Hypotension in Autonomic Failure
- Conditions
- Interventions
- Drug: AtomoxetineDrug: placeboDrug: AcarboseDevice: inflatable abdominal binder (sham)Drug: Pyridostigmine BromideDrug: YohimbineDrug: Midodrine HClDrug: ModafinilDrug: OctreotideOther: water intakeDrug: Diphenhydramine HydrochlorideDrug: Ranitidine HCLDrug: TranylcypromineDrug: Ergotamine/ CaffeineDrug: CelecoxibDrug: PseudoephedrineDrug: MethylphenidateDrug: IndomethacinDrug: IbuprofenDrug: Oxymetazoline 0.05% nasal solutionDietary Supplement: BovrilDrug: AcetazolamideDrug: Rivastigmine tartrateDrug: Carbidopa/levodopaDevice: Inflatable abdominal binder
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2017-01-18
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 389
- Registration Number
- NCT00223691
- Locations
- 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States
The Autonomic Nervous System and Obesity
- Conditions
- Interventions
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2018-03-01
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 128
- Registration Number
- NCT00179023
- Locations
- 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States
Acupuncture and Herbal Treatment of Chronic HIV Sinusitis
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Immune Enhancement Project
- Target Recruit Count
- 40
- Registration Number
- NCT00002149
- Locations
- 🇺🇸
Immune Enhancement Project, San Francisco, California, United States
Preventing Frequent Sinus Infections in HIV-Infected Patients
- Conditions
- Locations
- 🇺🇸
Univ of California / San Diego Treatment Ctr, San Diego, California, United States
🇺🇸Thomas Jefferson Univ Hosp, Philadelphia, Pennsylvania, United States
🇺🇸Stanford at Kaiser / Kaiser Permanente Med Ctr, San Francisco, California, United States
Drug Development Updates
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