Fluorouracil
- Generic Name
- Fluorouracil
- Brand Names
- Actikerall, Carac, Efudex, Fluoroplex, Tolak
- Drug Type
- Small Molecule
- Chemical Formula
- C4H3FN2O2
- CAS Number
- 51-21-8
- Unique Ingredient Identifier
- U3P01618RT
- Background
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
- Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.
- Associated Conditions
- Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis
- Associated Therapies
- -
Immediate Compared With Delayed Chemotherapy in Advanced Colorectal Cancer Without Signs or Symptoms of Disease
- First Posted Date
- 2004-08-31
- Last Posted Date
- 2020-04-06
- Lead Sponsor
- NCIC Clinical Trials Group
- Target Recruit Count
- 67
- Registration Number
- NCT00002570
- Locations
- 🇺🇸
Quain & Ramstad Clinic, P.C., Bismarck, North Dakota, United States
🇺🇸Rapid City Regional Hospital, Rapid City, South Dakota, United States
🇺🇸CCOP - Iowa Oncology Research Association, Des Moines, Iowa, United States
Combination Chemotherapy in Treating Patients With Recurrent Metastatic Colorectal Cancer
- Conditions
- First Posted Date
- 2004-08-25
- Last Posted Date
- 2009-01-13
- Target Recruit Count
- 109
- Registration Number
- NCT00003260
- Locations
- 🇫🇷
Hopital Saint Antoine, Paris, France
Combination Chemotherapy in Treating Patients With Advanced Head and Neck Cancer
- Conditions
- First Posted Date
- 2004-08-24
- Last Posted Date
- 2013-06-21
- Lead Sponsor
- Eastern Cooperative Oncology Group
- Registration Number
- NCT00002888
- Locations
- 🇺🇸
Herbert Irving Comprehensive Cancer Center, New York, New York, United States
🇺🇸Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States
🇺🇸Veterans Affairs Outpatient Clinic - Martinez, Martinez, California, United States
Combination Chemotherapy Before and After Surgery in Treating Patients With Stomach Cancer
- Conditions
- First Posted Date
- 2004-08-24
- Last Posted Date
- 2013-07-03
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Target Recruit Count
- 50
- Registration Number
- NCT00002783
- Locations
- 🇺🇸
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
Standard Chemotherapy Compared With High-Dose Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Women With Breast Cancer
- Conditions
- First Posted Date
- 2004-08-24
- Last Posted Date
- 2013-11-06
- Lead Sponsor
- Scottish Cancer Therapy Network
- Target Recruit Count
- 600
- Registration Number
- NCT00002755
- Locations
- 🇬🇧
St. James's Hospital, Leeds, England, United Kingdom
🇬🇧Addenbrooke's NHS Trust, Cambridge, England, United Kingdom
🇬🇧Cheltenham General Hospital, Cheltenham, England, United Kingdom
Combination Chemotherapy Compared With Mitoxantrone in Treating Older Patients With Advanced Breast Cancer
- Conditions
- First Posted Date
- 2004-08-23
- Last Posted Date
- 2013-12-18
- Lead Sponsor
- Leiden University Medical Center
- Registration Number
- NCT00002498
- Locations
- 🇳🇱
Leiden University Medical Center, Leiden, Netherlands
🇳🇱St. Radboud University Hospital, Nijmegen, Netherlands
Tamoxifen Following Combination Chemotherapy in Treating Women With Operable Invasive Breast Cancer
- Conditions
- First Posted Date
- 2004-08-23
- Last Posted Date
- 2013-11-06
- Lead Sponsor
- Scottish Cancer Therapy Network
- Target Recruit Count
- 2000
- Registration Number
- NCT00002579
- Locations
- 🇬🇧
Leicester Royal Infirmary NHS Trust, Leicester, England, United Kingdom
🇬🇧Aberdeen Royal Infirmary, Aberdeen, Scotland, United Kingdom
🇬🇧Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
Monoclonal Antibody Therapy Plus Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
- Conditions
- First Posted Date
- 2004-08-16
- Last Posted Date
- 2013-06-27
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Target Recruit Count
- 18
- Registration Number
- NCT00003543
- Locations
- 🇺🇸
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
Combination Chemotherapy in Treating Patients With Advanced Cancer of the Pancreas
- Conditions
- First Posted Date
- 2004-08-12
- Last Posted Date
- 2014-05-22
- Lead Sponsor
- University of Southern California
- Target Recruit Count
- 21
- Registration Number
- NCT00002955
- Locations
- 🇺🇸
USC/Norris Comprehensive Cancer Center, Los Angeles, California, United States
Combination Chemotherapy in Treating Patients With Metastatic or Recurrent Cancer of the Stomach or Esophagus
- Conditions
- First Posted Date
- 2004-08-10
- Last Posted Date
- 2013-12-19
- Lead Sponsor
- Robert H. Lurie Cancer Center
- Registration Number
- NCT00005607
- Locations
- 🇺🇸
Vanderbilt Cancer Center, Nashville, Tennessee, United States
🇺🇸University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania, United States
🇺🇸Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States
Drug Development Updates
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