Nitrofurantoin
- Generic Name
- Nitrofurantoin
- Brand Names
- Furadantin, Macrobid, Macrodantin
- Drug Type
- Small Molecule
- Chemical Formula
- C8H6N4O5
- CAS Number
- 67-20-9
- Unique Ingredient Identifier
- 927AH8112L
- Background
Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections. Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein. This drug is more resistant to the development of bacterial resistance because it acts on man...
- Indication
Nitrofurantoin is indicated to treat acute uncomplicated urinary tract infections.
- Associated Conditions
- Acute Cystitis, Urinary Tract Infection
- Associated Therapies
- -
Prophylactic Antibiotics for Urinary Tract Infections After Robot-Assisted Radical Cystectomy
- Conditions
- Interventions
- First Posted Date
- 2020-08-06
- Last Posted Date
- 2024-07-17
- Lead Sponsor
- Roswell Park Cancer Institute
- Target Recruit Count
- 89
- Registration Number
- NCT04502095
- Locations
- 🇺🇸
Roswell Park Cancer Institute, Buffalo, New York, United States
Comparative Study to Evaluate Efficacy and Safety of Gepotidacin to Nitrofurantoin in Treatment of Uncomplicated Urinary Tract Infection (UTI)
- Conditions
- Interventions
- First Posted Date
- 2019-12-05
- Last Posted Date
- 2023-07-18
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 1606
- Registration Number
- NCT04187144
- Locations
- 🇵🇱
GSK Investigational Site, Warszawa, Poland
A Study to Evaluate Efficacy and Safety of Gepotidacin in the Treatment of Uncomplicated Urinary Tract Infection (UTI)
- Conditions
- Interventions
- First Posted Date
- 2019-07-16
- Last Posted Date
- 2023-06-22
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 1531
- Registration Number
- NCT04020341
- Locations
- 🇬🇧
GSK Investigational Site, Peterborough, United Kingdom
INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI
- First Posted Date
- 2017-10-03
- Last Posted Date
- 2019-06-06
- Lead Sponsor
- Mayo Clinic
- Registration Number
- NCT03299387
Treatment of Asymptomatic Bacteriuria in Pregnancy
- Conditions
- Interventions
- First Posted Date
- 2016-09-22
- Last Posted Date
- 2018-04-18
- Lead Sponsor
- Saint Joseph Mercy Health System
- Target Recruit Count
- 13
- Registration Number
- NCT02911662
- Locations
- 🇺🇸
St. Joseph Mercy Hospital, Ypsilanti, Michigan, United States
The Preventive Infection Role of One Week Antibiotics Before Minimally Invasive Upper Tract Lithotomy
- Conditions
- Interventions
- First Posted Date
- 2016-06-03
- Last Posted Date
- 2019-10-01
- Target Recruit Count
- 150
- Registration Number
- NCT02789579
- Locations
- 🇨🇳
Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University School of Medicine.Kongjiang Road 1665,, Shanghai, Shanghai, China
Nitrofurantoin Prophylaxis During Catheter-managed Acute Urinary Retention After Pelvic Reconstructive Surgery
- First Posted Date
- 2016-04-04
- Last Posted Date
- 2019-05-29
- Lead Sponsor
- Halina M Zyczynski, MD
- Target Recruit Count
- 154
- Registration Number
- NCT02727322
- Locations
- 🇺🇸
Georgetown/MedStar Hospital Center, Washington, District of Columbia, United States
🇺🇸Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States
Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary Tract
- First Posted Date
- 2013-12-27
- Last Posted Date
- 2023-09-28
- Target Recruit Count
- 292
- Registration Number
- NCT02021006
- Locations
- 🇮🇹
Pediatric Nephrology Dialysis and Transplant Unit IRCCS Ca'Granda, Milan, Italy
Study Comparing Nitrofurantoin to Fosfomycin for Acute Urinary Tract Infection in Women
- First Posted Date
- 2013-10-21
- Last Posted Date
- 2017-05-02
- Lead Sponsor
- University Hospital, Geneva
- Target Recruit Count
- 600
- Registration Number
- NCT01966653
- Locations
- 🇮🇱
Tel Aviv University, Tel Aviv, Israel
🇵🇱Lodz University Hospital, Lodz, Poland
🇨🇭University Hospitals of Geneva, Geneva, Switzerland
Suppressive Therapy With Oral Antibiotics for Prevention of Postoperative Urinary Tract Infection (UTI)
- First Posted Date
- 2011-10-12
- Last Posted Date
- 2017-02-13
- Lead Sponsor
- Duke University
- Target Recruit Count
- 163
- Registration Number
- NCT01450800
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
Drug Development Updates
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