Sildenafil
- Generic Name
- Sildenafil
- Brand Names
- Liqrev, Revatio, Viagra, Vizarsin, Sildenafil Actavis, Sildenafil ratiopharm, Granpidam, Sildenafil Teva, Mysildecard
- Drug Type
- Small Molecule
- Chemical Formula
- C22H30N6O4S
- CAS Number
- 139755-83-2
- Unique Ingredient Identifier
- 3M7OB98Y7H
- Background
In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) . The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently faci...
- Indication
Sildenafil is a phosphodiesterase-5 (PDE5) inhibitor that is predominantly employed for two primary indications:
(1) the treatment of erectile dysfunction ; and
(2) treatment of pulmonary hypertension, where:
...
- Associated Conditions
- Erectile Dysfunction, NYHA Functional Class II-III Pulmonary arterial hypertension, Premature Ejaculation, Pulmonary Arterial Hypertension (PAH)
- Associated Therapies
- -
Study to Determine a Preference Between Sildenafil or Tadalafil Treatment for Problems Getting an Erection
- First Posted Date
- 2007-10-22
- Last Posted Date
- 2007-10-22
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 160
- Registration Number
- NCT00547352
- Locations
- 🇰🇷
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon- Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Seoul, Korea, Republic of
Acute Effects of Sildenafil on Endothelial Function in People With Diabetes
- Conditions
- First Posted Date
- 2007-09-11
- Last Posted Date
- 2007-09-11
- Lead Sponsor
- Ruhr University of Bochum
- Target Recruit Count
- 40
- Registration Number
- NCT00527995
- Locations
- 🇩🇪
German Diabetes Center, Duesseldorf, North Rhine-Westphalia, Germany
Effect of Nightly Versus Prn Sildenafil on Early Return of Erectile Function Following Laparoscopic Radical Prostatectomy
- First Posted Date
- 2007-08-06
- Last Posted Date
- 2008-12-01
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 100
- Registration Number
- NCT00511498
- Locations
- 🇺🇸
Johns Hopkins Bayview Medical Center, Baltimore, Maryland, United States
Sildenafil After the Fontan Operation
- Conditions
- Interventions
- First Posted Date
- 2007-07-27
- Last Posted Date
- 2015-05-05
- Lead Sponsor
- Children's Hospital of Philadelphia
- Target Recruit Count
- 28
- Registration Number
- NCT00507819
Safety and Clinical Effectiveness of 2 Lower Dose Combined PDE5i's vs. Single Maximal Dose PDE5i
- Conditions
- Interventions
- First Posted Date
- 2007-07-10
- Last Posted Date
- 2010-10-22
- Lead Sponsor
- Rambam Health Care Campus
- Target Recruit Count
- 46
- Registration Number
- NCT00498680
- Locations
- 🇮🇱
Neuro-urology unit, Rambam Medical Center, Haifa, Israel
Sildenafil Therapy for Pulmonary Hypertension and Sickle Cell Disease
- Conditions
- Interventions
- First Posted Date
- 2007-06-27
- Last Posted Date
- 2016-01-06
- Target Recruit Count
- 74
- Registration Number
- NCT00492531
- Locations
- 🇺🇸
University of Colorado, Denver, Colorado, United States
🇺🇸University of Illinois at Chicago, Chicago, Illinois, United States
🇬🇧Imperial College London and Hammersmith Hospital, London, United Kingdom
Sildenafil Effects on Pulmonary Haemodynamics and Gas Exchange in Chronic Obstructive Pulmonary Disease (COPD)
- Conditions
- Interventions
- First Posted Date
- 2007-06-26
- Last Posted Date
- 2009-11-10
- Lead Sponsor
- Hospital Clinic of Barcelona
- Target Recruit Count
- 20
- Registration Number
- NCT00491803
- Locations
- 🇪🇸
Hospital clinic, Barcelona, Spain
Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus
- Conditions
- Interventions
- First Posted Date
- 2007-05-24
- Last Posted Date
- 2018-02-12
- Lead Sponsor
- University of Colorado, Denver
- Target Recruit Count
- 4
- Registration Number
- NCT00478335
- Locations
- 🇺🇸
University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, United States
🇩🇰University of Aarhus, Aarhus, Denmark
The Pharmacological Basis for the Increase in Visual Time Constants Induced by Single Oral Doses of Sildenafil
- Conditions
- First Posted Date
- 2007-04-20
- Last Posted Date
- 2010-01-12
- Lead Sponsor
- University of Cambridge
- Target Recruit Count
- 12
- Registration Number
- NCT00463957
- Locations
- 🇬🇧
University of Cambridge, Cambridge, United Kingdom
FDA Phase IV - Commitment - Retinal Function Study
- Conditions
- Interventions
- First Posted Date
- 2007-04-18
- Last Posted Date
- 2015-03-19
- Lead Sponsor
- Bayer
- Target Recruit Count
- 63
- Registration Number
- NCT00461565
Drug Development Updates
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