Sildenafil
- Generic Name
- Sildenafil
- Brand Names
- Liqrev, Revatio, Viagra, Vizarsin, Sildenafil Actavis, Sildenafil ratiopharm, Granpidam, Sildenafil Teva, Mysildecard
- Drug Type
- Small Molecule
- Chemical Formula
- C22H30N6O4S
- CAS Number
- 139755-83-2
- Unique Ingredient Identifier
- 3M7OB98Y7H
- Background
In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) . The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently faci...
- Indication
Sildenafil is a phosphodiesterase-5 (PDE5) inhibitor that is predominantly employed for two primary indications:
(1) the treatment of erectile dysfunction ; and
(2) treatment of pulmonary hypertension, where:
...
- Associated Conditions
- Erectile Dysfunction, NYHA Functional Class II-III Pulmonary arterial hypertension, Premature Ejaculation, Pulmonary Arterial Hypertension (PAH)
- Associated Therapies
- -
A Placebo-Controlled Single-Dose Trial of Sildenafil in Schizophrenia
- Conditions
- First Posted Date
- 2007-04-04
- Last Posted Date
- 2011-06-29
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 18
- Registration Number
- NCT00455715
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
Combination Therapy in Pulmonary Arterial Hypertension
- Conditions
- Interventions
- First Posted Date
- 2007-02-09
- Last Posted Date
- 2013-06-05
- Lead Sponsor
- Actelion
- Target Recruit Count
- 100
- Registration Number
- NCT00433329
- Locations
- 🇺🇸
UCLA - David Geffen School of Medicine, Los Angeles, California, United States
🇺🇸Morton Plant Hospital (Bay Area Chest Physicians, P.A.), Clearwater, Florida, United States
🇺🇸University of Pittsburgh Medical Center - Presbyterian, Pittsburgh, Pennsylvania, United States
The Effect of Sildenafil in Preterm Infants With Evolving Chronic Lung Disease
- First Posted Date
- 2007-02-05
- Last Posted Date
- 2015-09-23
- Lead Sponsor
- Mercy Hospital for Women, Australia
- Target Recruit Count
- 20
- Registration Number
- NCT00431418
- Locations
- 🇦🇺
Mercy Hospital for Women, Heidelburg, Victoria, Australia
Effect of Chronic PDE5-Inhibition on Endothelial Function in Diabetics
- Conditions
- First Posted Date
- 2007-01-11
- Last Posted Date
- 2007-01-11
- Lead Sponsor
- IRCCS San Raffaele
- Target Recruit Count
- 30
- Registration Number
- NCT00420901
- Locations
- 🇮🇹
San Raffaele EUR, Roma, Italy
PDE5-Inhibition With Sildenafil in Chronic Heart Failure
- Conditions
- First Posted Date
- 2006-12-05
- Last Posted Date
- 2006-12-14
- Lead Sponsor
- University of Milan
- Target Recruit Count
- 40
- Registration Number
- NCT00407446
- Locations
- 🇮🇹
Marco Guazzi, MD, PhD University of Milano, Milano, Italy
Study of Sildenafil for Treatment of SSRI-Antidepressant Sexual Dysfunction in Women
- Conditions
- First Posted Date
- 2006-09-12
- Last Posted Date
- 2006-09-12
- Lead Sponsor
- University of New Mexico
- Target Recruit Count
- 100
- Registration Number
- NCT00375297
- Locations
- 🇺🇸
University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States
Sildenafil Study to Treat Idiopathic Pulmonary Fibrosis
- Conditions
- Interventions
- First Posted Date
- 2006-08-02
- Last Posted Date
- 2017-11-01
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 29
- Registration Number
- NCT00359736
- Locations
- 🇺🇸
VA Medical Center, Miami, Miami, Florida, United States
Does Oral Sildenafil (Viagra) Decrease Mean Pulmonary Artery Pressure After Cardiac Surgery?
- First Posted Date
- 2006-06-07
- Last Posted Date
- 2015-07-31
- Lead Sponsor
- Unity Health Toronto
- Target Recruit Count
- 40
- Registration Number
- NCT00334490
- Locations
- 🇨🇦
St. Michael's Hospital, Toronto, Ontario, Canada
Study of Sildenafil in Advanced Heart Failure.
- Conditions
- First Posted Date
- 2006-04-03
- Last Posted Date
- 2009-08-11
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 40
- Registration Number
- NCT00309790
Study of Sildenafil in Patient With Heart Failure.
- Conditions
- First Posted Date
- 2006-04-03
- Last Posted Date
- 2006-04-03
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 40
- Registration Number
- NCT00309816
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.