Sildenafil
- Generic Name
- Sildenafil
- Brand Names
- Liqrev, Revatio, Viagra, Vizarsin, Sildenafil Actavis, Sildenafil ratiopharm, Granpidam, Sildenafil Teva, Mysildecard
- Drug Type
- Small Molecule
- Chemical Formula
- C22H30N6O4S
- CAS Number
- 139755-83-2
- Unique Ingredient Identifier
- 3M7OB98Y7H
- Background
In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) . The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently faci...
- Indication
Sildenafil is a phosphodiesterase-5 (PDE5) inhibitor that is predominantly employed for two primary indications:
(1) the treatment of erectile dysfunction ; and
(2) treatment of pulmonary hypertension, where:
...
- Associated Conditions
- Erectile Dysfunction, NYHA Functional Class II-III Pulmonary arterial hypertension, Premature Ejaculation, Pulmonary Arterial Hypertension (PAH)
- Associated Therapies
- -
The "VISION" Trial: Ventavis Inhalation With Sildenafil to Improve and Optimize Pulmonary Arterial Hypertension
- Conditions
- Interventions
- First Posted Date
- 2006-03-14
- Last Posted Date
- 2019-04-16
- Lead Sponsor
- Actelion
- Target Recruit Count
- 67
- Registration Number
- NCT00302211
- Locations
- 🇺🇸
University of Maryland Hospital, Baltimore, Maryland, United States
🇺🇸GLVA Medical Center, Los Angeles, California, United States
🇺🇸University of Connecticut Health Center, Farmington, Connecticut, United States
Effect of Sildenafil on Endothelial Function
- Conditions
- First Posted Date
- 2006-02-28
- Last Posted Date
- 2006-02-28
- Lead Sponsor
- Rambam Health Care Campus
- Target Recruit Count
- 60
- Registration Number
- NCT00297544
- Locations
- 🇮🇱
Rambam Medical Center, Recanati Autonomic Dysfunction CTR, Haifa, Israel
Healthy Volunteer Study of Sildenafil Effects Upon Vision
- Conditions
- First Posted Date
- 2005-11-10
- Last Posted Date
- 2005-11-10
- Lead Sponsor
- University of Cambridge
- Registration Number
- NCT00251784
Titration Study to Evaluate Efficacy and Satisfaction of Viagra in Men With Erectile Function.
- Conditions
- First Posted Date
- 2005-11-07
- Last Posted Date
- 2021-02-01
- Target Recruit Count
- 510
- Registration Number
- NCT00249730
- Locations
- 🇬🇧
Pfizer Investigational Site, Glasgow, United Kingdom
Evaluation of the Index of Sexual Life Questionnaire
- Conditions
- First Posted Date
- 2005-10-28
- Last Posted Date
- 2021-02-01
- Target Recruit Count
- 120
- Registration Number
- NCT00245596
- Locations
- 🇫🇷
Pfizer Investigational Site, Toulouse, France
Treatment of Supine Hypertension in Autonomic Failure
- Conditions
- Interventions
- Drug: PlaceboDrug: ClonidineDrug: Nitroglycerin transdermalDrug: Dipyridamole/ Aspirin (Aggrenox)Drug: Desmopressin (DDAVP)Drug: SildenafilDrug: NifedipineDrug: HydralazineDrug: HydrochlorothiazideDrug: BosentanDrug: DiltiazemDrug: EplerenoneDrug: guanfacineDietary Supplement: L-arginineDrug: captoprilDrug: carbidopaDrug: losartanDrug: metoprolol tartrateDrug: nebivolol hydrochlorideDrug: prazosin hydrochlorideDrug: tamsulosin hydrochlorideOther: Head-up tilt.Drug: aliskirenOther: Local heat stress
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2017-10-13
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 152
- Registration Number
- NCT00223717
- Locations
- 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States
Use of Sildenafil (Viagra) in Diabetic Men With Erectile Dysfunction: the Impact on Blood Vessels
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2018-11-06
- Lead Sponsor
- Lawson Health Research Institute
- Target Recruit Count
- 24
- Registration Number
- NCT00199563
- Locations
- 🇨🇦
St. Joseph's Health Care London/Urology Clinic, London, Ontario, Canada
Sildenafil and Pulmonary Artery Pressure
- Conditions
- First Posted Date
- 2005-09-05
- Last Posted Date
- 2013-10-08
- Lead Sponsor
- University of Chicago
- Target Recruit Count
- 10
- Registration Number
- NCT00145938
- Locations
- 🇺🇸
University of Chicago, Chicago, Illinois, United States
Sildenafil For Meniere's Disease
- Conditions
- First Posted Date
- 2005-09-05
- Last Posted Date
- 2021-02-01
- Target Recruit Count
- 163
- Registration Number
- NCT00145483
- Locations
- 🇦🇺
Pfizer Investigational Site, Melbourne, Victoria, Australia
Effectiveness and Safety of Viagra in Men With ED and LUTS Due to Benign Prostatic Hyperplasia (BPH)
- Conditions
- First Posted Date
- 2005-09-02
- Last Posted Date
- 2021-02-01
- Target Recruit Count
- 350
- Registration Number
- NCT00143221
Drug Development Updates
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