Captopril

Generic Name
Captopril
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C9H15NO3S
CAS Number
62571-86-2
Unique Ingredient Identifier
9G64RSX1XD
Background

Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.

Indication

For the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics). May be used to treat congestive heart failure in combination with other drugs (e.g. cardiac glycosides, diuretics, β-adrenergic blockers). May improve survival in patients with left ventricular dysfunction following myocardial...

Associated Conditions
Aldosteronism, Anatomic renal artery stenosis, Congestive Heart Failure (CHF), Diabetic Nephropathy, Heart Failure, Hypertension, Hypertensive crisis, Non-STEMI Acute Coronary Syndrome, Raynaud's Phenomenon, Ejection fraction of 40% or less Left ventricular dysfunction
Associated Therapies
-

Assessment of the Effect of Captopril Versus Combination of Captopril and Pentoxifylline on Reducing Proteinuria in Type 2 Diabetic Nephropathy

First Posted Date
2008-04-22
Last Posted Date
2008-04-22
Lead Sponsor
Shiraz University of Medical Sciences
Target Recruit Count
70
Registration Number
NCT00663949
Locations
🇮🇷

Shiraz University of Medical Sciences ,Nemazee and Faghihi Hospital, Shiraz, Fars, Iran, Islamic Republic of

A Clinical Study to Evaluate Renal Hemodynamic Responses to Aliskiren in Patients With Type 2 Diabetes Mellitus

First Posted Date
2008-04-17
Last Posted Date
2012-08-29
Lead Sponsor
Novartis
Target Recruit Count
45
Registration Number
NCT00660309
Locations
🇺🇸

Novartis Investigator Site, Boston, Massachusetts, United States

In Vivo Angiostatin Generation Using Tissue Plasminogen Activator and Captopril in Treating Patients With Progressive Metastatic Cancer

First Posted Date
2004-07-12
Last Posted Date
2012-06-11
Lead Sponsor
Northwestern University
Registration Number
NCT00086723
Locations
🇺🇸

Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago, Illinois, United States

Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation

Phase 3
Completed
Conditions
First Posted Date
2004-05-03
Last Posted Date
2012-06-06
Lead Sponsor
Northwestern University
Target Recruit Count
35
Registration Number
NCT00004230
Locations
🇺🇸

Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States

Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy

First Posted Date
2004-02-11
Last Posted Date
2018-03-08
Lead Sponsor
Radiation Therapy Oncology Group
Target Recruit Count
81
Registration Number
NCT00077064
Locations
🇺🇸

Mount Carmel Health - West Hospital, Columbus, Ohio, United States

🇺🇸

Doctors Hospital at Ohio Health, Columbus, Ohio, United States

🇺🇸

Great Lakes Cancer Institute at McLaren Regional Medical Center, Flint, Michigan, United States

and more 84 locations
© Copyright 2024. All Rights Reserved by MedPath