Azathioprine
- Generic Name
- Azathioprine
- Brand Names
- Azasan, Imuran, Jayempi
- Drug Type
- Small Molecule
- Chemical Formula
- C9H7N7O2S
- CAS Number
- 446-86-6
- Unique Ingredient Identifier
- MRK240IY2L
- Background
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index. Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transp...
- Indication
Azathioprine is indicated to treat rheumatoid arthritis and prevent renal transplant rejection.
- Associated Conditions
- Atopic Dermatitis, Crohn's Disease (CD), Immune Thrombocytopenia (ITP), Kidney Transplant Rejection, Lupus Nephritis, Multiple Sclerosis, Pericarditis, Psoriasis, Rheumatoid Arthritis, Uveitis
- Associated Therapies
- -
Conventional Step-Up Versus Infliximab Monotherapy in Patients With Ulcerative Colitis (P05553)
- Conditions
- Interventions
- First Posted Date
- 2009-09-25
- Last Posted Date
- 2017-04-13
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 28
- Registration Number
- NCT00984568
Preventing Postoperative Relapse in Crohn's Disease Patients at Risk: Azathioprine Versus Mesalazine
- Conditions
- Interventions
- First Posted Date
- 2009-07-27
- Last Posted Date
- 2012-06-26
- Lead Sponsor
- Dr. Falk Pharma GmbH
- Target Recruit Count
- 78
- Registration Number
- NCT00946946
- Locations
- 🇩🇪
Robert-Bosch Krankenhaus, Innere Medizin I, Stuttgart, Germany
🇦🇹Universitaetsklinik für Innere Medizin III, Abteilung Gastroenterologie and Hepatologie, Vienna, Austria
Prevention of Skin Cancer in High Risk Patients After Conversion to a Sirolimus-based Immunosuppressive Protocol
- Conditions
- Interventions
- First Posted Date
- 2009-03-20
- Last Posted Date
- 2015-09-02
- Lead Sponsor
- Charite University, Berlin, Germany
- Target Recruit Count
- 44
- Registration Number
- NCT00866684
- Locations
- 🇩🇪
Universitätsklinikum Erlangen, Medizinische Klinik IV, Erlangen, Bavaria, Germany
🇩🇪Universitätsklinikum Münster, Klinik und Poliklinik für Hautkrankheiten, Münster, North Rhine-Westphalia, Germany
🇩🇪Universitätsklinikum Münster, Med. Klinik und Poliklinik D, Münster, North Rhine-Westphalia, Germany
Abatacept and Cyclophosphamide Combination Therapy for Lupus Nephritis
- First Posted Date
- 2008-10-17
- Last Posted Date
- 2016-02-08
- Target Recruit Count
- 137
- Registration Number
- NCT00774852
- Locations
- 🇺🇸
Feinstein Institute, Manhasset, New York, United States
🇺🇸UT Southwestern, Dallas, Texas, United States
🇺🇸University of Alabama, Birmingham, Birmingham, Alabama, United States
Anti-Cytokine Therapy for Vasculitis
- First Posted Date
- 2008-09-16
- Last Posted Date
- 2008-09-16
- Target Recruit Count
- 37
- Registration Number
- NCT00753103
- Locations
- 🇬🇧
University Hospitals Birmingham NHS Foundation Trust, Birmingham, West Midlands, United Kingdom
Efficacy Study of Two Treatments in the Remission of Vasculitis
- Conditions
- Interventions
- First Posted Date
- 2008-09-08
- Last Posted Date
- 2018-03-02
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 117
- Registration Number
- NCT00748644
- Locations
- 🇫🇷
Hopital Cochin, Paris, France
A Study to Evaluate Ocrelizumab in Patients With Nephritis Due to Systemic Lupus Erythematosus (BELONG)
- First Posted Date
- 2008-02-29
- Last Posted Date
- 2020-12-22
- Lead Sponsor
- Genentech, Inc.
- Target Recruit Count
- 381
- Registration Number
- NCT00626197
Azathioprine Versus Placebo in Pemphigus Vulgaris Treated With Prednisolone
- Conditions
- Interventions
- First Posted Date
- 2008-02-29
- Last Posted Date
- 2010-11-30
- Lead Sponsor
- Tehran University of Medical Sciences
- Target Recruit Count
- 48
- Registration Number
- NCT00626678
- Locations
- 🇮🇷
Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of
LCP-Tacro vs. Azathioprine for the Treatment of Autoimmune Hepatitis
- Conditions
- Interventions
- First Posted Date
- 2008-02-06
- Last Posted Date
- 2020-03-17
- Lead Sponsor
- Veloxis Pharmaceuticals
- Target Recruit Count
- 13
- Registration Number
- NCT00608894
- Locations
- 🇺🇸
Mayo Clinic - Jacksonville, Jacksonville, Florida, United States
🇺🇸Mayo Clinic, Rochester, Minnesota, United States
🇺🇸Mount Sinai Medical Center, New York, New York, United States
Correlation of Genetic Polymorphism of Azathioprine Metabolizing Enzymes and Correlation to Clinical Adverse Effects
- First Posted Date
- 2007-09-05
- Last Posted Date
- 2012-05-17
- Lead Sponsor
- National Taiwan University Hospital
- Target Recruit Count
- 166
- Registration Number
- NCT00525473
- Locations
- 🇨🇳
National Taiwan University Hospital, Taipei, Taiwan
Drug Development Updates
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