Azathioprine

Generic Name: Azathioprine

Brand Names: Azasan, Imuran, Jayempi

Drug Type: Small Molecule

Chemical Formula: C_₉H_₇N_₇O_₂S

CAS Number: 446-86-6

Unique Ingredient Identifier: MRK240IY2L

Background: Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index. Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transp...

Indication: Azathioprine is indicated to treat rheumatoid arthritis and prevent renal transplant rejection.

Associated Conditions: Atopic Dermatitis, Crohn's Disease (CD), Immune Thrombocytopenia (ITP), Kidney Transplant Rejection, Lupus Nephritis, Multiple Sclerosis, Pericarditis, Psoriasis, Rheumatoid Arthritis, Uveitis

Associated Therapies: -

Clinical Trials

Belimumab in Remission of VASculitis

Phase 3

Completed

Conditions: Vasculitis

Interventions: Biological: Placebo
Biological: Belimumab 10 mg/kg
Drug: Azathioprine

First Posted Date: 2012-08-13

Last Posted Date: 2018-04-17

Lead Sponsor: Human Genome Sciences Inc., a GSK Company

Target Recruit Count: 106

Registration Number: NCT01663623

Locations: 🇬🇧
GSK Investigational Site, Oxford, United Kingdom

Adalimumab on Preventing Post-chirurgic Recurrence on Crohn´s Disease

Phase 3

Completed

Conditions: Crohn´s Disease

Interventions: Drug: Metronidazole
Drug: Adalimumab
Drug: Azathioprine

First Posted Date: 2012-03-28

Last Posted Date: 2015-03-17

Lead Sponsor: Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa

Target Recruit Count: 86

Registration Number: NCT01564823

Locations: 🇪🇸
Hospital General Dr. Negrín, Las Palmas de Gran Canaria, Islas Canarias, Spain
🇪🇸
Hospital Reina Sofía, Córdoba, Spain
🇪🇸
Hospital Arquitecto Marcide, Ferrol, La Coruña, Spain

and more 19 locations

Steroids and Azathioprine in Advanced IgAN

Phase 3

Completed

Conditions: IgA Nephropathy
Chronic Kidney Disease

Interventions: Drug: methylprednisolone
Drug: azathioprine
Drug: prednisone

First Posted Date: 2011-07-13

Last Posted Date: 2011-07-13

Lead Sponsor: A. Manzoni Hospital

Target Recruit Count: 46

Registration Number: NCT01392833

Drug Use Investigation for IMURAN (Azathioprine) Tablet (Hepatic Transplantation)

Completed

Conditions: Liver Diseases

Interventions: Drug: Azathioprine

First Posted Date: 2011-07-11

Last Posted Date: 2012-09-03

Lead Sponsor: GlaxoSmithKline

Target Recruit Count: 41

Registration Number: NCT01390766

Special Drug Use Investigation for IMURAN (Azathioprine) Tablet (Pulmones Transplantation)

Completed

Conditions: Liver Diseases

Interventions: Drug: Azathioprine

First Posted Date: 2011-06-27

Last Posted Date: 2013-05-13

Lead Sponsor: GlaxoSmithKline

Target Recruit Count: 39

Registration Number: NCT01381432

Efficacy and Safety of Two Treatment Algorithms in Adults With Moderate to Severe Crohn's Disease

Phase 3

Completed

Conditions: Crohn's Disease

Interventions: Biological: Adalimumab
Drug: Prednisone
Drug: Azathioprine

First Posted Date: 2010-11-05

Last Posted Date: 2018-01-16

Lead Sponsor: AbbVie (prior sponsor, Abbott)

Target Recruit Count: 252

Registration Number: NCT01235689

Leflunomide Versus Azathioprine for Maintenance Therapy of Lupus Nephritis

Not Applicable

Conditions: Nephritis
Lupus

Interventions: Drug: Azathioprine
Drug: Leflunomide

First Posted Date: 2010-07-29

Last Posted Date: 2010-08-11

Lead Sponsor: RenJi Hospital

Target Recruit Count: 200

Registration Number: NCT01172002

Locations: 🇨🇳
RenJi Hospital, ShangHai, Shanghai, China

Enteric-coated Mycophenolate Sodium Versus Azathioprine for the Extra-renal Lupus Manifestations

Phase 4

Completed

Conditions: Systemic Lupus Erythematosus

Interventions: Drug: Enteric-Coated Mycophenolate Sodium
Drug: Azathioprine

First Posted Date: 2010-04-28

Last Posted Date: 2016-10-04

Lead Sponsor: Hospital Universitari Vall d'Hebron Research Institute

Target Recruit Count: 240

Registration Number: NCT01112215

Locations: 🇪🇸
Vall d'Hebron Hospital, Barcelona, Spain

Long-Term Study of Multi-target Therapy as Maintenance Treatment for Lupus Nephritis

Not Applicable

Completed

Conditions: Lupus Nephritis

Interventions: Drug: Azathioprine
Drug: Multi-target therapy

First Posted Date: 2010-01-26

Last Posted Date: 2015-07-31

Lead Sponsor: Zhi-Hong Liu, M.D.

Target Recruit Count: 206

Registration Number: NCT01056237

Locations: 🇨🇳
Research Institute of Nephrology, Jinling Hospital, Nanjing, Jiangsu, China

Efficacy Study of T2 Versus AZA to Maintain Clinical and Endoscopic Remission in Postoperative Crohn's Disease

Not Applicable

Conditions: Crohn's Disease

Interventions: Drug: T2
Drug: Azathioprine

First Posted Date: 2009-11-18

Last Posted Date: 2013-06-04

Lead Sponsor: Jinling Hospital, China

Target Recruit Count: 100

Registration Number: NCT01015391

Locations: 🇨🇳
General Surgery Institute,Jinling Hospital, Nanjing, Jiangsu, China

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