Praziquantel

Generic Name: Praziquantel

Brand Names: Biltricide

Drug Type: Small Molecule

Chemical Formula: C_₁₉H_₂₄N_₂O_₂

CAS Number: 55268-74-1

Unique Ingredient Identifier: 6490C9U457

Background: An anthelmintic used in most schistosome and many cestode infestations.

Indication: For the treatment of infections due to all species of schistosoma.

Associated Conditions: Cestode infections, Cysticercosis, Liver fluke infection, Trematode infections, Schistosoma infection

Associated Therapies: -

Clinical Trials

Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African Children

Not Applicable

Conditions: Seasonal Malaria Chemoprevention
Mass Drug Administration With Anthelminthic Drugs
Soil Transmitted Helminths
Schistosomiasis
Malaria
Integrated Control

Interventions: Drug: Praziquantel
Drug: Albendazole
Drug: Sulfadoxine pyrimethamine
Drug: Amodiaquine

First Posted Date: 2022-04-29

Last Posted Date: 2022-07-14

Lead Sponsor: London School of Hygiene and Tropical Medicine

Target Recruit Count: 600

Registration Number: NCT05354258

Locations: 🇸🇳
Saraya Health Centre, Saraya, Kedougou, Senegal

Evaluation of Artesunate-mefloquine as a Novel Alternative Treatment for Schistosomiasis in African Children

Phase 3

Completed

Conditions: Schistosoma Haematobium
Schistosoma Mansoni

Interventions: Drug: Artesunate + Mefloquine
Drug: Praziquantel

First Posted Date: 2019-03-28

Last Posted Date: 2021-04-05

Lead Sponsor: Institute of Tropical Medicine, Belgium

Target Recruit Count: 726

Registration Number: NCT03893097

Locations: 🇸🇳
Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal

Schistosomiasis Diagnosis Using a CAA Antigen Test

Phase 3

Conditions: Schistosomiasis Hematobium
Diagnostic
Drug Reaction
Pregnancy

Interventions: Diagnostic Test: UCP-LF CAA
Drug: Praziquantel
Diagnostic Test: composite diagnostic

First Posted Date: 2018-12-19

Last Posted Date: 2021-07-27

Lead Sponsor: Centre de Recherche Médicale de Lambaréné

Target Recruit Count: 100

Registration Number: NCT03779347

Locations: 🇬🇦
Centre de Recherches Médicales de Lambaréné, Lambaréné, Moyen Ogooué, Gabon
🇬🇦
Centre de Recherches Medicales de Lambaréné, Lambaréné, Gabon

Praziquantel in Children Under Age 4

Phase 2

Conditions: Schistosomiasis
Schistosomiasis Mansoni
Schistosoma Japonicum Infection

Interventions: Drug: Praziquantel

First Posted Date: 2018-08-21

Last Posted Date: 2022-05-20

Lead Sponsor: Rhode Island Hospital

Target Recruit Count: 600

Registration Number: NCT03640377

Locations: 🇬🇧
London School of Tropical Hygiene and Medicine, London, United Kingdom
🇺🇬
Medical Research Council, Entebbe, Uganda

Praziquantel Bioequivalence Study

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Cisticid
Drug: Biltricide

First Posted Date: 2018-02-19

Last Posted Date: 2019-09-18

Lead Sponsor: Merck KGaA, Darmstadt, Germany

Target Recruit Count: 60

Registration Number: NCT03437447

Locations: 🇲🇽
Clínica de Enfermedades Crónicas y de Procedimientos Especiales, Sociedad Civil (SC), México, Mexico

Effect of Schistosomiasis Mansoni on HIV Susceptibility and Female Genital Immunology

Phase 4

Completed

Conditions: Schistosomiasis Mansoni
HIV

Interventions: Drug: Praziquantel

First Posted Date: 2016-08-25

Last Posted Date: 2016-10-27

Lead Sponsor: University of Toronto

Target Recruit Count: 34

Registration Number: NCT02878564

Locations: 🇺🇬
UVRI-IAVI HIV Vaccine program, Entebbe, Wakiso, Uganda

Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis

Phase 4

Withdrawn

Conditions: Schistosomiasis

Interventions: Drug: Praziquantel

First Posted Date: 2016-04-12

Last Posted Date: 2019-12-17

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Registration Number: NCT02734186

Schistosoma Mansoni in Mwanza Region, Tanzania

Not Applicable

Completed

Conditions: Schistosoma Mansoni

Interventions: Drug: Praziquantel

First Posted Date: 2014-06-13

Last Posted Date: 2017-02-10

Lead Sponsor: DBL -Institute for Health Research and Development

Target Recruit Count: 37500

Registration Number: NCT02162875

Locations: 🇹🇿
National Institute for Mediacal Research, Mwanza, Lake Region, Tanzania

Schistosoma Mansoni Morbidity in Children Aged 1-5 Years

Phase 2

Completed

Conditions: Intestinal Schistosomiasis

Interventions: Drug: Praziquantel

First Posted Date: 2013-07-17

Last Posted Date: 2014-09-17

Lead Sponsor: Makerere University

Target Recruit Count: 800

Registration Number: NCT01901484

Locations: 🇺🇬
Child Health & Development Centre, College of Health Sciences , Makerere University, Kampala, Uganda

Impact IPT With Sulfadoxine-pyrimethamine or Sulfadoxine-pyrimethamine Plus Piperaquine in Schoolchildren

Phase 3

Completed

Conditions: Healthy

Interventions: Drug: Piperaquine
Drug: Sulfadoxine-pyrimethamine
Drug: Albendazole
Drug: Praziquantel

First Posted Date: 2012-11-07

Last Posted Date: 2014-02-04

Lead Sponsor: Universiteit Antwerpen

Target Recruit Count: 616

Registration Number: NCT01722539

Locations: 🇨🇬
Mokali health area of Biyela health zone, in Kinshasa province., Kinshasa, Kinshasa province, Congo

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