DeepMed Research

Acetylcholine

Generic Name: Acetylcholine

Brand Names: Miochol

Drug Type: Small Molecule

Chemical Formula: C_₇H_₁₆NO_₂

CAS Number: 51-84-3

Unique Ingredient Identifier: N9YNS0M02X

Background: A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications.

Indication: Used to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.

Clinical Trials

Microcirculatory Impairment in Patients With Leprosy

Not Applicable

Completed

Conditions: Lepromatous Leprosy

Interventions: Drug: acetylcholine Iontophoresis
Drug: sodium nitroprusside Iontophoresis

First Posted Date: 2014-03-12

Last Posted Date: 2014-03-12

Lead Sponsor: Curt Treu

Target Recruit Count: 20

Registration Number: NCT02085317

IR and Microvascular Blood Flow in SCI

Not Applicable

Completed

Conditions: Insulin Resistance
Spinal Cord Injury

Interventions: Drug: Acetylcholine Iontophoresis
Drug: Placebo Iontophoresis
Other: Heat application
Drug: Insulin iontophoresis

First Posted Date: 2014-01-13

Last Posted Date: 2017-03-07

Lead Sponsor: James J. Peters Veterans Affairs Medical Center

Target Recruit Count: 68

Registration Number: NCT02034331

Locations: 🇺🇸
James J. Peters VA Medical Center, Bronx, New York, United States

Endothelial Injury and Development of Coronary Intimal Thickening After Heart Transplantation

Phase 1

Terminated

Conditions: Cardiac Allograft Vasculopathy
Antibody Mediated Rejection

Interventions: Device: Optical Coherence Tomography
Drug: Acetylcholine
Procedure: Brachial Artery Flow Mediated Dilation

First Posted Date: 2013-05-07

Last Posted Date: 2017-09-06

Lead Sponsor: Gladwin, Mark, MD

Target Recruit Count: 12

Registration Number: NCT01848301

Locations: 🇺🇸
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States

Comparison of Endothelial Dysfunction (BMS vs SES) in the Same Patient With Multiple Coronary Artery Lesions

Phase 1

Completed

Conditions: Endothelial Dysfunction

Interventions: Drug: intracoronary infusion of acetylcholine

First Posted Date: 2010-11-17

Last Posted Date: 2010-11-17

Lead Sponsor: Azienda Ospedaliera San Camillo Forlanini

Target Recruit Count: 25

Registration Number: NCT01242306

Locations: 🇮🇹
Azienda Ospedaliera San Camillo Forlanini, Roma, Italy

Blood Markers for Inflammation and Coronary Artery Vasoreactivity Testing in Patients With Chest Pain and Normal Coronary Arteries

Not Applicable

Conditions: Endothelial Dysfunction
Atherosclerosis
Inflammation
Myocardial Ischemia

Interventions: Drug: Acetylcholine
Drug: Adenosine

First Posted Date: 2010-07-15

Last Posted Date: 2011-02-23

Lead Sponsor: St George's Healthcare NHS Trust

Target Recruit Count: 50

Registration Number: NCT01162824

Locations: 🇬🇧
Department of Cardiology, St George's Healthcare NHS Trust, London, England, United Kingdom

Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide (NO) Homeostasis

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Acetylcholine and Blood

First Posted Date: 2010-06-04

Last Posted Date: 2015-04-14

Lead Sponsor: Mark Gladwin

Target Recruit Count: 53

Registration Number: NCT01137656

Locations: 🇺🇸
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States

Bevacizumab and Endothelium Dependent Vasodilation

Not Applicable

Completed

Conditions: Hypertension
Cancer
Endothelial Dysfunction

Interventions: Drug: Acetylcholine
Drug: Nitroprusside
Drug: Bevacizumab

First Posted Date: 2010-05-19

Last Posted Date: 2013-01-10

Lead Sponsor: Radboud University Medical Center

Target Recruit Count: 24

Registration Number: NCT01125943

Locations: 🇳🇱
Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

Endothelial Dysfunction and Diabetes

Completed

Conditions: Type 1 Diabetes Mellitus

Interventions: Drug: Trinitrin
Drug: Neosynephrine 10% collyrium
Drug: Iontophoresis with acetylcholine delivery
Device: Dynamic Vessel Analyzer

First Posted Date: 2010-04-01

Last Posted Date: 2012-07-03

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 38

Registration Number: NCT01097551

Locations: 🇫🇷
Hôpital LARIBOISIERE Service d'Ophtalmologie, Paris, France

The Effects of C-type Natriuretic Peptide on Human Forearm Blood Vessels

Not Applicable

Withdrawn

Conditions: Ischaemia-reperfusion (IR) Injury

Interventions: Drug: C-type natriuretic peptide (CNP)
Drug: Saline
Drug: Acetylcholine

First Posted Date: 2010-02-25

Last Posted Date: 2020-05-05

Lead Sponsor: Queen Mary University of London

Registration Number: NCT01075776

Locations: 🇬🇧
Queen Mary University London, London, United Kingdom

Investigating Systemic and Local Vascular Responses to Apelin in the Context of Renin-angiotensin Upregulation

Not Applicable

Completed

Conditions: Heart Disease
Heart Failure
Vasodilatation

Interventions: Drug: Apelin
Drug: Acetylcholine
Drug: Sodium nitroprusside
Drug: Systemic apelin infusion

First Posted Date: 2009-05-14

Last Posted Date: 2010-08-10

Lead Sponsor: University of Edinburgh

Target Recruit Count: 12

Registration Number: NCT00901719

Locations: 🇬🇧
Clincial Research Facility, Royal Infirmary of Edinburgh, 51 Little France Cresc, Edinburgh, United Kingdom

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