DeepMed Research

Acetylcholine

Generic Name: Acetylcholine

Brand Names: Miochol

Drug Type: Small Molecule

Chemical Formula: C_₇H_₁₆NO_₂

CAS Number: 51-84-3

Unique Ingredient Identifier: N9YNS0M02X

Background: A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications.

Indication: Used to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.

Clinical Trials

Early Neurovascular Adaptations in Aging Women

Early Phase 1

Recruiting

Conditions: Aging
Women
Blood Flow
Sympathetic Nervous System

Interventions: Drug: Norepinephrine
Drug: Isoproterenol
Drug: Acetylcholine
Drug: Nitroprusside
Drug: Estrogen

First Posted Date: 2024-07-25

Last Posted Date: 2024-10-01

Lead Sponsor: University of Missouri-Columbia

Target Recruit Count: 64

Registration Number: NCT06520982

Locations: 🇺🇸
University of Missouri-Columbia, Columbia, Missouri, United States

Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation

Early Phase 1

Not yet recruiting

Conditions: Endothelial Function

Interventions: Drug: Acetylcholine

First Posted Date: 2024-07-15

Last Posted Date: 2024-07-15

Lead Sponsor: University of Iowa

Target Recruit Count: 56

Registration Number: NCT06499844

Locations: 🇺🇸
University of Iowa, Iowa City, Iowa, United States

Investigation of Endothelium-dependent Vasodilation in Human Gingiva

Not Applicable

Active, not recruiting

Conditions: Vasodilation
Oral Soft Tissue Conditions

Interventions: Drug: Acetylcholine Chloride

First Posted Date: 2024-06-12

Last Posted Date: 2024-06-12

Lead Sponsor: Semmelweis University

Target Recruit Count: 80

Registration Number: NCT06454084

Locations: 🇭🇺
Department for Restorative Dentistry and Endodontics, Semmelweis University, Budapest, Hungary

Role of Endothelial Function in SCI CVD Risk

Recruiting

Conditions: Spinal Cord Injuries
Cardiovascular Diseases
Endothelial Dysfunction

Interventions: Procedure: Brachial intra-arterial infusion of vasoactive and antioxidant drugs (acetylcholine, nitroprusside, ascorbic acid)
Procedure: venous occlusion plethysmography
Drug: Acetylcholine
Drug: Sodium Nitroprusside
Drug: Ascorbic acid
Procedure: venous phlebotomy

First Posted Date: 2024-06-05

Last Posted Date: 2024-08-20

Lead Sponsor: Craig Hospital

Target Recruit Count: 60

Registration Number: NCT06443151

Locations: 🇺🇸
Craig Hospital, Englewood, Colorado, United States

Estrogen and Microvascular Function

Active, not recruiting

Conditions: Microvasculature
Cardiovascular Diseases
Estrogen

Interventions: Drug: Nω-nitro-L-arginine methyl ester (L-NAME)
Drug: Acetylcholine
Drug: Sodium Nitroprusside

First Posted Date: 2023-09-21

Last Posted Date: 2025-05-01

Lead Sponsor: Medical College of Wisconsin

Target Recruit Count: 20

Registration Number: NCT06043310

Locations: 🇺🇸
Froedtert Hospital, Wauwatosa, Wisconsin, United States

Role of NADPH Oxidase in Microvascular Dysfunction Following GDM

Early Phase 1

Recruiting

Conditions: Vascular Endothelial Function
Oxidative Stress
Gestational Diabetes

Interventions: Drug: Acetylcholine
Drug: Insulin aspart

First Posted Date: 2023-07-14

Last Posted Date: 2025-05-13

Lead Sponsor: Anna Stanhewicz, PhD

Target Recruit Count: 40

Registration Number: NCT05946798

Locations: 🇺🇸
University of Iowa, Iowa City, Iowa, United States

Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes

Early Phase 1

Recruiting

Conditions: Vascular Endothelial Function
Gestational Diabetes

Interventions: Drug: Acetylcholine
Drug: insulin aspart

First Posted Date: 2023-07-14

Last Posted Date: 2025-05-13

Lead Sponsor: Anna Stanhewicz, PhD

Target Recruit Count: 28

Registration Number: NCT05946785

Locations: 🇺🇸
University of Iowa, Iowa City, Iowa, United States

Prenatal Aspirin and Postpartum Vascular Function

Early Phase 1

Recruiting

Conditions: Microvascular Function
Preeclampsia

Interventions: Drug: Acetylcholine
Drug: Endothelin-1

First Posted Date: 2022-12-16

Last Posted Date: 2024-05-28

Lead Sponsor: Anna Stanhewicz, PhD

Target Recruit Count: 60

Registration Number: NCT05653973

Locations: 🇺🇸
University of Iowa, Iowa City, Iowa, United States

Hot Flashes and Neurovascular Function in Women

Not Applicable

Recruiting

Conditions: Hot Flashes
Menopause
Vasomotor System; Labile

Interventions: Other: Sympathoexcitatory stressors
Drug: Sodium Nitroprusside
Drug: Acetylcholine
Drug: Terbutaline
Drug: Norepinephrine

First Posted Date: 2022-01-18

Last Posted Date: 2024-05-24

Lead Sponsor: Mayo Clinic

Target Recruit Count: 120

Registration Number: NCT05193968

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Endothelium Dependent and Non-dependent Vasodilatation in Human Gingiva

Not Applicable

Completed

Conditions: Vasodilatation
Oral Soft Tissue Conditions

Interventions: Drug: Nitroglycerin
Drug: Acetylcholine

First Posted Date: 2021-06-09

Last Posted Date: 2021-06-14

Lead Sponsor: Semmelweis University

Target Recruit Count: 24

Registration Number: NCT04918563

Locations: 🇭🇺
Semmelweis University, Department of Conservative Dentistry, Budapest, Hungary

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