Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
Comparative Analysis of Analgesic Efficacy and Maternal Satisfaction: by Single Shot Intrathecal Analgesia (SSSA) in Normal Labor
- Conditions
- Vaginal DeliveryNormal Labor
- Interventions
- First Posted Date
- 2025-02-12
- Last Posted Date
- 2025-03-07
- Lead Sponsor
- Jehan George Sadek
- Target Recruit Count
- 90
- Registration Number
- NCT06823349
- Locations
- 🇪🇬
Aswan University Hospital, Aswan, Egypt
Premixed, Sequential and Manually Mixed Administration of Intrathecal Fentanyl and Bupivacaine in Cesarean Section
- Conditions
- PremixedSequentialManually MixedIntrathecalFentanylBupivacaineCesarean Section
- Interventions
- First Posted Date
- 2025-02-11
- Last Posted Date
- 2025-02-13
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 90
- Registration Number
- NCT06820203
- Locations
- 🇪🇬
Tanta University, Tanta, El-Gharbia, Egypt
Dexmedetomidine Versus Fentanyl As Adjuvants to Erector Spinae Plane Block for Postoperative Analgesia Following Simple Nephrectomy: a Randomized Clinical Trial
- Conditions
- Nephrectomy
- Interventions
- First Posted Date
- 2025-01-29
- Last Posted Date
- 2025-01-29
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 46
- Registration Number
- NCT06799442
- Locations
- 🇪🇬
Assiut University, Assiut, Egypt
Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy
- Conditions
- Post-induction HypotensionLidocaineOpioidEmergency Laparotomy
- Interventions
- First Posted Date
- 2025-01-13
- Last Posted Date
- 2025-01-22
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 150
- Registration Number
- NCT06772727
- Locations
- 🇪🇬
Faculty of Medicine, Cairo University, Cairo, Egypt
Comparison of Safety and Efficacy for Different Sedation Regimens During Colonoscopy
- Conditions
- Deep SedationsConscious SedationColonoscopy
- Interventions
- First Posted Date
- 2025-01-08
- Last Posted Date
- 2025-01-08
- Lead Sponsor
- Qassim Health Cluster
- Target Recruit Count
- 157
- Registration Number
- NCT06763705
- Locations
- 🇸🇦
King Saud Hospital, Unaizah, Qassim, Saudi Arabia
Comparison of the Efficacy of Intraperitoneal Instillation of Fentanyl Versus Nalbuphine As Adjuvants to Bupivacaine for Postoperative Pain Relief in Patients Undergoing Laparoscopic Cholecystectomy
- Conditions
- Laparoscopic Cholecystectomy
- Interventions
- First Posted Date
- 2024-12-09
- Last Posted Date
- 2024-12-09
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 70
- Registration Number
- NCT06722963
Comparsion Between Intrathecal Fentanyl and Intravenous Nalbuphine As a Postoperative Analgesia in Lower Limb Surgeries
- First Posted Date
- 2024-12-06
- Last Posted Date
- 2024-12-06
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 100
- Registration Number
- NCT06720506
Role of Prophylactic Antiemetics in Women Receiving Intrathecal Morphine and Lipophilic Opioids Added to Bupivacaine for Cesarean Section
- Conditions
- Cesarean Section
- Interventions
- First Posted Date
- 2024-11-25
- Last Posted Date
- 2024-11-25
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 100
- Registration Number
- NCT06704139
Comparison Between Effect of Systemic Fentanyl Infusion and Fentanyl Added as An Adjuvant to Lidocaine in Bier Block For Controlling Pain in Patients Undergoing Hand Surgeries
- Conditions
- Bier BlockHand Surgery
- Interventions
- First Posted Date
- 2024-11-20
- Last Posted Date
- 2025-04-18
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 84
- Registration Number
- NCT06696586
A Randomized Study Comparing of Three Doses Nebulized Fentanyl in Older Adults
- Conditions
- Treatment Side EffectsMusculoskeletal Pain
- Interventions
- First Posted Date
- 2024-11-14
- Last Posted Date
- 2024-11-14
- Target Recruit Count
- 120
- Registration Number
- NCT06689124
- Locations
- 🇹🇭
Faculty of Medicine,Vajira Hospital, Bangkok, Thailand
🇹🇭Jiraporn Sri-on, Bangkok, Thailand
Drug Development Updates
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