Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
The Effect of Choice of Intraoperative Opioid on Postoperative Pain
- First Posted Date
- 2012-03-02
- Last Posted Date
- 2019-09-30
- Lead Sponsor
- NorthShore University HealthSystem
- Target Recruit Count
- 164
- Registration Number
- NCT01542645
- Locations
- 🇺🇸
NorthShore University HealthSystem, Evanston, Illinois, United States
Effect of Intravenous Patient-controlled Analgesia (IV-PCA) With Fentanyl in Adults for Acute Postoperative Pain Control
- Conditions
- NauseaVomiting
- First Posted Date
- 2012-02-07
- Last Posted Date
- 2012-02-07
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 2000
- Registration Number
- NCT01527890
- Locations
- 🇰🇷
Gangnam Severance Hospital, Seoul, Korea, Republic of
Impact of Muscle Afferent Feedback During Exercise in Patients With Chronic Obstructive Pulmonary Disease (COPD)
- Conditions
- Chronic Obstructive Pulmonary Disease
- Interventions
- Drug: Placebo comparatorDrug: Fentanyl
- First Posted Date
- 2012-02-01
- Last Posted Date
- 2012-02-01
- Lead Sponsor
- Laval University
- Target Recruit Count
- 8
- Registration Number
- NCT01522729
- Locations
- 🇨🇦
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Québec, Quebec, Canada
Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Subjects Undergoing Procedure-Type Sedation
- Conditions
- UltrasoundMRIsCT Scans
- Interventions
- First Posted Date
- 2012-01-26
- Last Posted Date
- 2017-03-20
- Lead Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
- Target Recruit Count
- 91
- Registration Number
- NCT01519167
Breakthrough Dyspnea Fentanyl Study in Cancer Patients
- Conditions
- Advanced CancersDyspnea
- Interventions
- First Posted Date
- 2012-01-24
- Last Posted Date
- 2014-08-22
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 26
- Registration Number
- NCT01515566
- Locations
- 🇺🇸
UT MD Anderson Cancer Center, Houston, Texas, United States
Fentanyl Use for Sedation in Esophagogastroduodenoscopy
- First Posted Date
- 2012-01-23
- Last Posted Date
- 2013-01-30
- Lead Sponsor
- St. Joseph's Healthcare Hamilton
- Target Recruit Count
- 139
- Registration Number
- NCT01514695
- Locations
- 🇨🇦
St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada
Open-Label, Safety, and Efficacy Study of Dexmedetomidine in Preterm Subjects Ages ≥28 Weeks to <36 Weeks Gestational Age
- Conditions
- Anesthesia
- Interventions
- First Posted Date
- 2012-01-12
- Last Posted Date
- 2017-08-23
- Lead Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
- Target Recruit Count
- 6
- Registration Number
- NCT01508455
Compare Propofol to Fentanyl and Midazolam for Colonoscopy
- Conditions
- Colon CancerColonic DiverticulosisRectal Cancer
- Interventions
- First Posted Date
- 2011-12-08
- Last Posted Date
- 2023-05-23
- Lead Sponsor
- Saint Joseph Mercy Health System
- Target Recruit Count
- 289
- Registration Number
- NCT01488045
- Locations
- 🇺🇸
Saint Joseph Mercy Hospital, Ann Arbor, Michigan, United States
Effect of Sedation on Diagnostic Injections
- Conditions
- Sacroiliac Joint PainSympathetically Maintained Pain
- Interventions
- First Posted Date
- 2011-11-17
- Last Posted Date
- 2016-12-15
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 73
- Registration Number
- NCT01472835
- Locations
- 🇺🇸
Johns Hopkins Blaustein Pain Treatment Center, Baltimore, Maryland, United States
The Effect of Intravenous Fentanyl Prior the End of Surgery on Emergence Agitation in Paediatric Patients After General Anesthesia
- First Posted Date
- 2011-09-26
- Last Posted Date
- 2011-09-26
- Lead Sponsor
- Prince of Songkla University
- Target Recruit Count
- 144
- Registration Number
- NCT01440114
- Locations
- 🇹🇭
Faculty of Medicine, Prince of Songkla University, Hat-Yai, Sonkhla, Thailand
Drug Development Updates
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