Fentanyl

Generic Name
Fentanyl
Brand Names
Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
Drug Type
Small Molecule
Chemical Formula
C22H28N2O
CAS Number
437-38-7
Unique Ingredient Identifier
UF599785JZ
Background

Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.

Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.

Fentanyl was FDA approved in 1968.

Indication

Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.

Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.

Associated Conditions
Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
Associated Therapies
Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
Clinical Trials
Related News

The Effect of Dexmedetomidine on Postoperative Analgesia

First Posted Date
2011-06-14
Last Posted Date
2012-03-08
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
95
Registration Number
NCT01373021
Locations
🇰🇷

Seoul national university hospital, Seoul, Korea, Republic of

Effect of Fentanyl on Coughing and Recovery After Anesthesia With an LMA Laryngeal Mask Airway)for Airway Management

Phase 4
Completed
Conditions
Ambulatory Surgery
Coughing
Interventions
Drug: Fentanyl
Drug: Saline
First Posted Date
2011-06-08
Last Posted Date
2016-04-05
Lead Sponsor
Cedars-Sinai Medical Center
Target Recruit Count
100
Registration Number
NCT01368809
Locations
🇺🇸

Cedars Sinai Medical center, Los Angeles, California, United States

Epidural Morphine Versus Epidural Fentanyl Infusion Following Cesarean Section

Not Applicable
Terminated
Conditions
Pain
Interventions
Drug: Preservative free morphine
Drug: Fentanyl
First Posted Date
2011-06-01
Last Posted Date
2022-11-14
Lead Sponsor
Goodman, Evan, M.D.
Target Recruit Count
2
Registration Number
NCT01362998
Locations
🇺🇸

University Hospitals Case Medical Center, Cleveland, Ohio, United States

An Assessment of Fentanyl Dose Requirements in Opioid-maintained Individuals

Not Applicable
Conditions
Opioid Dependence
Interventions
Drug: Fentanyl
First Posted Date
2011-05-23
Last Posted Date
2013-02-06
Lead Sponsor
University of Adelaide
Target Recruit Count
24
Registration Number
NCT01358500
Locations
🇦🇺

PARC, Royal Adelaide Hospital, Adelaide, South Australia, Australia

Nasal Fentanyl And Renal Colic

First Posted Date
2011-04-20
Last Posted Date
2011-04-20
Lead Sponsor
Valduce Hospital
Target Recruit Count
65
Registration Number
NCT01339624
Locations
🇮🇹

Valduce Hospital, Como, Italy

Cycling of Sedative Infusions in Critically Ill Pediatric Patients

Not Applicable
Terminated
Conditions
Respiratory Failure
Interventions
Drug: Midazolam
Drug: Normal saline
Drug: Fentanyl
First Posted Date
2011-04-11
Last Posted Date
2019-01-15
Lead Sponsor
Javier Gelvez, MD
Target Recruit Count
25
Registration Number
NCT01333059
Locations
🇺🇸

Cook Children's Medical Center, Fort Worth, Texas, United States

Safety Study of Analgesia After Craniotomy Surgery With End Tidal (ET) Carbon Dioxide (CO2) Monitoring

Phase 4
Completed
Conditions
Pain
Interventions
Drug: Fentanyl
First Posted Date
2011-04-01
Last Posted Date
2017-05-31
Lead Sponsor
Johns Hopkins University
Target Recruit Count
137
Registration Number
NCT01327677
Locations
🇺🇸

The Johns Hopkins Hospital, Baltimore, Maryland, United States

Treatment of Pain in Head-and-Neck Cancer Patients: is Methadone More Effective?

Phase 4
Completed
Conditions
Pain
Cancer of Head and Neck
Interventions
Drug: fentanyl
Drug: methadone
First Posted Date
2011-03-17
Last Posted Date
2015-07-16
Lead Sponsor
Maastricht University Medical Center
Target Recruit Count
134
Registration Number
NCT01317589
Locations
🇳🇱

University Hospital Maastricht, Maastricht, Netherlands

Study to Test the Safety and Efficacy of Cannabidiol as a Treatment Intervention for Opioid Relapse

Phase 1
Completed
Conditions
Opiate Addiction
Interventions
Drug: Fentanyl
Drug: Cannabidiol
First Posted Date
2011-03-10
Last Posted Date
2013-03-22
Lead Sponsor
Hurd,Yasmin, Ph.D.
Target Recruit Count
18
Registration Number
NCT01311778
Locations
🇺🇸

Mount Sinai Medical Center, New York, New York, United States

Sedation in Endoscopic Retrograde Cholangiopancreatography (ERCP) With or Without Opioids

Not Applicable
Completed
Conditions
Chronic Pain
Interventions
Drug: Remifentanil
Drug: Normal saline
Drug: Fentanyl
First Posted Date
2011-02-25
Last Posted Date
2013-08-05
Lead Sponsor
University of Athens
Target Recruit Count
180
Registration Number
NCT01304342
Locations
🇬🇷

Department of Anesthesiology, Aretaieio Hospital, Athens, Greece

© Copyright 2024. All Rights Reserved by MedPath
HomeTerms & ConditionsPrivacy Policy