Fentanyl

Generic Name: Fentanyl

Brand Names: Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₈N_₂O

CAS Number: 437-38-7

Unique Ingredient Identifier: UF599785JZ

Background: Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.

Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.

Fentanyl was FDA approved in 1968.

Indication: Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.

Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.

Associated Conditions: Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain

Associated Therapies: Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy

Clinical Trials

Safety of Dexmedetomidine in Severe Traumatic Brain Injury

Phase 2

Withdrawn

Conditions: Traumatic Brain Injury

Interventions: Drug: Propofol
Drug: Precedex
Drug: Fentanyl

First Posted Date: 2009-11-04

Last Posted Date: 2023-09-13

Lead Sponsor: University of Maryland, Baltimore

Registration Number: NCT01007773

Locations: 🇺🇸
University of Maryland Medical Center, Baltimore, Maryland, United States

Effect of Inhaled Fentanyl on Dyspnea and Exercise Tolerance in Chronic Obstructive Pulmonary Disease (COPD)

Not Applicable

Completed

Conditions: Chronic Obstructive Pulmonary Disease

Interventions: Drug: normal saline (placebo)
Drug: fentanyl

First Posted Date: 2009-09-10

Last Posted Date: 2019-07-12

Lead Sponsor: Queen's University

Target Recruit Count: 16

Registration Number: NCT00974220

Locations: 🇨🇦
Respiratory Investigation Unit, Kingston General Hospital, Kingston, Ontario, Canada

Dexmedetomidine Infusion in Hypospadias Surgery

Phase 3

Completed

Conditions: Pain

Interventions: Drug: Dexmedetomidine and Fentanyl
Drug: Fentanyl

First Posted Date: 2009-06-23

Last Posted Date: 2009-06-23

Lead Sponsor: University of Jordan

Target Recruit Count: 48

Registration Number: NCT00926705

Locations: 🇯🇴
Jordan University Hospital, Amman, Jordan

Prospective Study About Clinical and Pharmacogenetic Safety of Opioid Use for Chronic Pain

Phase 4

Suspended

Conditions: Chronic Pain

Interventions: Drug: Buprenorphine
Drug: Morphine
Drug: Oxycodone
Drug: Fentanyl

First Posted Date: 2009-06-10

Last Posted Date: 2014-01-09

Lead Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia

Target Recruit Count: 320

Registration Number: NCT00916890

Locations: 🇮🇹
Servizio di Anestesia e Rianimazione e Terapia Antalgica - Ospedale Sant'Orsola-Poliambulanza, Brescia, Italy
🇮🇹
Servizio di Anestesia e Rianimazione e Terapia Antalgica - Ospedale Mellino Mellini, Chiari, Italy
🇮🇹
Struttura Complessa di Medicina Interna - Ospedale Civile di Voghera - Azienda Ospedaliera provincia di Pavia, Voghera, Pavia, Italy

and more 3 locations

Propofol and Fentanyl Versus Midazolam and Fentanyl for Endoscopy Sedation in Cirrhotic Patients

Phase 4

Conditions: Cirrhosis

Interventions: Drug: Propofol
Drug: Midazolam
Drug: Fentanyl

First Posted Date: 2009-05-21

Last Posted Date: 2009-05-25

Lead Sponsor: Federal University of São Paulo

Target Recruit Count: 210

Registration Number: NCT00906139

Locations: 🇧🇷
Federal University of São Paulo, São Paulo, Brazil

Study Evaluating Safety and Efficacy of Dexmedetomidine (DEX) in Intubated and Mechanically Ventilated Pediatric Intensive Care Unit (PICU) Subjects

Phase 3

Completed

Conditions: Sedation

Interventions: Drug: Dexmedetomidine
Drug: Midazolam
Drug: Fentanyl
Drug: Morphine

First Posted Date: 2009-04-03

Last Posted Date: 2015-08-14

Lead Sponsor: Hospira, now a wholly owned subsidiary of Pfizer

Target Recruit Count: 175

Registration Number: NCT00875550

Locations: 🇺🇸
Pediatric Critical Care, Los Angeles, California, United States
🇺🇸
Advocate Lutheran General Children's Hospital, Park Ridge, Illinois, United States
🇺🇸
University of Chicago Comer Children's Hospital, Chicago, Illinois, United States

and more 32 locations