Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
Continuous Infusion of Fentanyl in Preterm on MV
- Conditions
- PainInfant, Premature, DiseasesRespiration; Insufficient or Poor, Newborn
- Interventions
- Drug: 5% glucose solution
- First Posted Date
- 2007-12-12
- Last Posted Date
- 2011-10-12
- Target Recruit Count
- 128
- Registration Number
- NCT00571636
- Locations
- 🇮🇹
St'Orsola-Malpighi General Hospital, Bologna, BO, Italy
Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty
- Conditions
- Osteoarthritis of the Knee
- Interventions
- First Posted Date
- 2007-11-22
- Last Posted Date
- 2011-08-08
- Lead Sponsor
- Asker & Baerum Hospital
- Target Recruit Count
- 102
- Registration Number
- NCT00562627
- Locations
- 🇳🇴
Asker and Baerum Hospital, Rud, Norway
Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery
- Conditions
- Breast Cancer
- Interventions
- First Posted Date
- 2007-10-11
- Last Posted Date
- 2015-04-13
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 89
- Registration Number
- NCT00542542
- Locations
- 🇺🇸
UT MD Anderson Cancer Center, Houston, Texas, United States
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
- First Posted Date
- 2007-10-03
- Last Posted Date
- 2014-03-05
- Lead Sponsor
- INSYS Therapeutics Inc
- Target Recruit Count
- 130
- Registration Number
- NCT00538850
- Locations
- 🇺🇸
InSys Therapeutics, Incorporated, Chandler, Arizona, United States
Long-term Safety and Efficacy Study of Fentanyl Sublingual Spray for the Treatment of Breakthrough Cancer Pain
- First Posted Date
- 2007-10-03
- Last Posted Date
- 2013-10-11
- Lead Sponsor
- INSYS Therapeutics Inc
- Target Recruit Count
- 319
- Registration Number
- NCT00538863
Fentanyl With or Without Bupivacaine in Reducing Pain in Patients Undergoing Video-Assisted Chest Surgery
- Conditions
- Perioperative/Postoperative ComplicationsPain
- Interventions
- First Posted Date
- 2007-10-02
- Last Posted Date
- 2017-02-09
- Lead Sponsor
- Roswell Park Cancer Institute
- Target Recruit Count
- 30
- Registration Number
- NCT00538499
- Locations
- 🇺🇸
Roswell Park Cancer Institute, Buffalo, New York, United States
Effects of General Anesthesia and Spinal-Morphine Anesthesia on Recovery and Comfort After Benign Abdominal Hysterectomy
- Conditions
- Hysterectomy (MeSH nr: E04.950.300.399)
- Interventions
- First Posted Date
- 2007-09-10
- Last Posted Date
- 2012-01-26
- Lead Sponsor
- Preben Kjolhede
- Target Recruit Count
- 180
- Registration Number
- NCT00527332
- Locations
- 🇸🇪
Värnamo Hospital, Värnamo, Sweden
🇸🇪Eksjö Hospital, Eksjö, Sweden
🇸🇪Ryhov Hospital, Jönköping, Sweden
Fentanyl for Treatment Pain Caused by Radiotherapy
- Conditions
- Pain
- First Posted Date
- 2007-09-03
- Last Posted Date
- 2010-04-28
- Lead Sponsor
- Johnson & Johnson Taiwan Ltd
- Target Recruit Count
- 163
- Registration Number
- NCT00523887
A Study of the Effect on Pain Control of Treatment With Fentanyl, Administered Through the Skin, in Patients With Rheumatoid Arthritis or Osteoarthritis
- Conditions
- Rheumatoid ArthritisArthritisOsteoarthritis
- First Posted Date
- 2007-09-03
- Last Posted Date
- 2010-11-25
- Lead Sponsor
- Janssen Pharmaceutica N.V., Belgium
- Target Recruit Count
- 264
- Registration Number
- NCT00524160
Comparison of Nasal Fentanyl and Oral Transmucosal Fentanyl (Actiq) in Cancer Breakthrough Pain (FT-019-IM)
- Conditions
- Pain
- First Posted Date
- 2007-07-04
- Last Posted Date
- 2012-05-07
- Lead Sponsor
- Nycomed
- Target Recruit Count
- 115
- Registration Number
- NCT00496392
- Locations
- 🇩🇰
Nycomed, Roskilde, Denmark
Drug Development Updates
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