Norepinephrine
- Generic Name
- Norepinephrine
- Brand Names
- Levophed
- Drug Type
- Small Molecule
- Chemical Formula
- C8H11NO3
- CAS Number
- 51-41-2
- Unique Ingredient Identifier
- X4W3ENH1CV
- Background
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
- Indication
Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
- Associated Conditions
- Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension
- Associated Therapies
- -
Phenylephrine or Norepinephrine for a Better Hemodynamic Stability
- Conditions
- Interventions
- First Posted Date
- 2017-07-12
- Last Posted Date
- 2018-01-23
- Target Recruit Count
- 40
- Registration Number
- NCT03215797
Effect of Vasopressors on Spinal Anaesthesia Induced Hypotension
- Conditions
- Interventions
- First Posted Date
- 2017-05-23
- Last Posted Date
- 2019-10-24
- Lead Sponsor
- Cukurova University
- Target Recruit Count
- 160
- Registration Number
- NCT03163914
- Locations
- 🇹🇷
Çukurova University Balcalı Hospital, Adana, Turkey
Norepinephrine Versus Ephedrine in Treatment of Hypotension During Spinal Anesthesia for Caesarean Section
- Conditions
- Interventions
- First Posted Date
- 2017-05-23
- Last Posted Date
- 2017-05-23
- Lead Sponsor
- Mongi Slim Hospital
- Target Recruit Count
- 110
- Registration Number
- NCT03163407
The Effect of Norepinephrine Versus Dopamine in Renal Transplant Recipients on Postoperative Graft Function
- First Posted Date
- 2017-04-11
- Last Posted Date
- 2017-10-20
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 44
- Registration Number
- NCT03107858
- Locations
- 🇪🇬
Assiut University Hospital, Assiut, Egypt
Blood Pressure During ESD is Related With the Postoperative Bleeding
- Conditions
- Interventions
- First Posted Date
- 2017-03-03
- Last Posted Date
- 2017-04-26
- Lead Sponsor
- Shanghai Zhongshan Hospital
- Target Recruit Count
- 296
- Registration Number
- NCT03070665
- Locations
- 🇨🇳
Zhongshan Hospital, Shanghai, SHA, China
Phenylephrine and Noradrenaline for Post Spinal Anesthesia Hypotension
- Conditions
- Interventions
- First Posted Date
- 2017-01-10
- Last Posted Date
- 2017-05-03
- Lead Sponsor
- Kasr El Aini Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT03015857
Evaluating the Effect of Standard-of-care Erythropoiesis-stimulating Agents on Forearm Blood Flow in Nondialysis-dependent Subjects With Anaemia Associated With Chronic Kidney Disease.
- Conditions
- Interventions
- First Posted Date
- 2016-12-09
- Last Posted Date
- 2024-02-07
- Target Recruit Count
- 29
- Registration Number
- NCT02987465
- Locations
- 🇬🇧
Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom
Norepinephrine and Phenylephrine for Maternal Cardiac Output During Spinal Anesthesia for Elective Cesarean Delivery
- First Posted Date
- 2016-11-21
- Last Posted Date
- 2017-03-10
- Lead Sponsor
- Jeju National University Hospital
- Target Recruit Count
- 50
- Registration Number
- NCT02969239
- Locations
- 🇰🇷
Jeju National University Hospital, Jeju, Korea, Republic of
A Comparison of Intermittent Intravenous Boluses of Phenylephrine and Norepinephrine to Prevent Spinal-induced Hypotension in Cesarean Deliveries
- First Posted Date
- 2016-11-15
- Last Posted Date
- 2017-05-24
- Target Recruit Count
- 112
- Registration Number
- NCT02962986
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Intravenous Bolus of Phenylephrine vs. Norepinephrine in Preventing Hypotension After Spinal Anesthesia
- Conditions
- Interventions
- First Posted Date
- 2016-08-03
- Last Posted Date
- 2017-10-26
- Lead Sponsor
- University Tunis El Manar
- Target Recruit Count
- 120
- Registration Number
- NCT02854787
- Locations
- 🇹🇳
Tunis maternity and neonatology center, minisetry of public health, Tunis, Tunisia
Drug Development Updates
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