Norepinephrine

Generic Name: Norepinephrine

Brand Names: Levophed

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₁NO_₃

CAS Number: 51-41-2

Unique Ingredient Identifier: X4W3ENH1CV

Background: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

Indication: Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.

Associated Conditions: Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension

Associated Therapies: -

Clinical Trials

Exploratory Study of Topical Norepinephrine in Breast Cancer Patients Receiving Radiotherapy

Phase 1

Withdrawn

Conditions: Radiodermatitis

Interventions: Drug: Norepinephrine

First Posted Date: 2012-03-06

Last Posted Date: 2012-05-28

Lead Sponsor: ProCertus BioPharm, Inc

Registration Number: NCT01544504

Locations: 🇺🇸
H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States

Vascular Dysfunction in Diabetes: Genes and Hormones

Terminated

Conditions: Diabetes Mellitus

First Posted Date: 2012-01-18

Last Posted Date: 2022-11-09

Lead Sponsor: Brigham and Women's Hospital

Target Recruit Count: 100

Registration Number: NCT01511042

Locations: 🇺🇸
Brigham and Women's Hospital- 221 Longwood Avenue, Boston, Massachusetts, United States

Vasopressin Versus Norepinephrine for the Management of Shock After Cardiac Surgery

Phase 3

Conditions: Shock

Interventions: Drug: Vasopressin
Drug: Norepinephrine

First Posted Date: 2012-01-06

Last Posted Date: 2013-02-12

Lead Sponsor: University of Sao Paulo

Target Recruit Count: 300

Registration Number: NCT01505231

Locations: 🇧🇷
Instituto do Coração, São Paulo, Brazil

Discontinuation Order of Vasopressors in Septic Shock

Not Applicable

Terminated

Conditions: Septic Shock

Interventions: Drug: Vasopressin
Drug: Norepinephrine

First Posted Date: 2011-12-15

Last Posted Date: 2015-01-30

Lead Sponsor: Samsung Medical Center

Target Recruit Count: 78

Registration Number: NCT01493102

Locations: 🇰🇷
Samsung Medical Center, Seoul, Korea, Republic of

Genetic Mechanisms in Human Hypertension

Terminated

Conditions: Hypertension

First Posted Date: 2011-10-20

Last Posted Date: 2021-05-12

Lead Sponsor: Brigham and Women's Hospital

Target Recruit Count: 150

Registration Number: NCT01456208

Locations: 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States

Caveolin-1 and Vascular Dysfunction

Phase 1

Conditions: Insulin Resistance
Hypertension

Interventions: Drug: Para-aminohippuric Acid
Drug: Angiotensin II
Drug: Norepinephrine

First Posted Date: 2011-08-31

Last Posted Date: 2022-03-14

Lead Sponsor: Brigham and Women's Hospital

Target Recruit Count: 120

Registration Number: NCT01426529

Locations: 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States

Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery

Phase 4

Completed

Conditions: Oral Cancer
Head and Neck Cancer
Free Flap
Hypotension

Interventions: Drug: Epinephrine
Drug: Norepinephrine
Drug: Dobutamine
Drug: Dopexamine

First Posted Date: 2011-08-16

Last Posted Date: 2011-08-16

Lead Sponsor: Oxford University Hospitals NHS Trust

Target Recruit Count: 25

Registration Number: NCT01418118

Locations: 🇬🇧
John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom

Exploratory Study of Norepinephrine to Prevent Alopecia in Head and Neck Cancer Patients Treated With Radiotherapy

Phase 1

Terminated

Conditions: Alopecia
Radiodermatitis

Interventions: Drug: Norepinephrine

First Posted Date: 2011-06-07

Last Posted Date: 2012-03-23

Lead Sponsor: ProCertus BioPharm, Inc

Target Recruit Count: 3

Registration Number: NCT01367990

Locations: 🇺🇸
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States

Exploratory Study of Norepinephrine to Prevent Radiodermatitis in Breast Cancer Patients

Phase 1

Terminated

Conditions: Radiodermatitis

Interventions: Drug: Norepinephrine

First Posted Date: 2010-12-20

Last Posted Date: 2013-04-19

Lead Sponsor: ProCertus BioPharm, Inc

Target Recruit Count: 10

Registration Number: NCT01263366

Locations: 🇺🇸
University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States

Norepinephrine as Early Vasopressor Therapy in Children Undergoing Mechanical Ventilation

Phase 4

Conditions: Shock
Mechanical Ventilation

Interventions: Drug: Placebo
Drug: Norepinephrine

First Posted Date: 2009-05-07

Last Posted Date: 2009-05-07

Lead Sponsor: Unidade de Terapia Intensiva

Target Recruit Count: 40

Registration Number: NCT00894621

Locations: 🇧🇷
Hospital Geral, Caxias do Sul, Rio Grande do Sul, Brazil

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