Norepinephrine

Generic Name: Norepinephrine

Brand Names: Levophed

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₁NO_₃

CAS Number: 51-41-2

Unique Ingredient Identifier: X4W3ENH1CV

Background: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

Indication: Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.

Associated Conditions: Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension

Clinical Trials

NE ED90 Bolus in C-Sec

Phase 4

Not yet recruiting

Conditions: Hypertension
Nausea
Hypotension
Pain
Arrhythmia

Interventions: Drug: Norepinephrine

First Posted Date: 2024-08-28

Last Posted Date: 2025-01-17

Lead Sponsor: Pontificia Universidad Catolica de Chile

Target Recruit Count: 60

Registration Number: NCT06574555

Locations: 🇨🇱
Hospital Clinico, Pontificia Universidad CAtolica de Chile, Santiago, RM, Chile

Early Neurovascular Adaptations in Aging Women

Early Phase 1

Recruiting

Conditions: Aging
Women
Blood Flow
Sympathetic Nervous System

Interventions: Drug: Norepinephrine
Drug: Isoproterenol
Drug: Acetylcholine
Drug: Nitroprusside
Drug: Estrogen

First Posted Date: 2024-07-25

Last Posted Date: 2024-10-01

Lead Sponsor: University of Missouri-Columbia

Target Recruit Count: 64

Registration Number: NCT06520982

Locations: 🇺🇸
University of Missouri-Columbia, Columbia, Missouri, United States

Epinephrine Vs Norepinephrine Infusion During Caesarean Delivery

Not Applicable

Not yet recruiting

Conditions: Hypotension
Spinal Block
Cesarean Section

Interventions: Drug: Norepinephrine
Drug: Epinephrine

First Posted Date: 2024-07-22

Last Posted Date: 2024-07-22

Lead Sponsor: Cairo University

Target Recruit Count: 212

Registration Number: NCT06512402

Locations: 🇪🇬
Cairo University, Cairo, Egypt

10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery

Not Applicable

Not yet recruiting

Conditions: Cesarean Section
Hypotension
Spinal Anesthesia

Interventions: Drug: 15 mcg Norepinephrine
Drug: 10 mcg Norepinephrine

First Posted Date: 2024-07-22

Last Posted Date: 2024-07-22

Lead Sponsor: Cairo University

Target Recruit Count: 184

Registration Number: NCT06512415

Locations: 🇪🇬
Cairo University, Cairo, Egypt

Norepinephrine and Phenylephrine for Spinal Anesthesia-induced Hypotension.

Not Applicable

Not yet recruiting

Conditions: Outcome

Interventions: Drug: Norepinephrine
Drug: Phenylephrine

First Posted Date: 2024-07-18

Last Posted Date: 2024-07-18

Lead Sponsor: General Hospital of Ningxia Medical University

Target Recruit Count: 2000

Registration Number: NCT06508359

Management of Postspinal Anesthesia Hypotension During Elective Cesarean Section: Baby Norepinephrine Versus Ephedrine

Not Applicable

Recruiting

Conditions: Anesthesia Complication
Vasopressor
Cesarean Section Complications
Hypotension During Surgery

Interventions: Drug: Ephedrine
Drug: Norepinephrine

First Posted Date: 2024-07-12

Last Posted Date: 2024-10-23

Lead Sponsor: Hopital Charles Nicolle

Target Recruit Count: 126

Registration Number: NCT06498076

Locations: 🇹🇳
Charles Nicolle Hospital, Tunis, Tunisia

Norepinephrine on Maternal Hypotension After Combined Lumbar and Epidural Anaesthesia

Phase 4

Recruiting

Conditions: Maternal Hypotension

Interventions: Drug: Norepinephrine

First Posted Date: 2024-07-12

Last Posted Date: 2024-07-12

Lead Sponsor: The Third People's Hospital of Bengbu

Target Recruit Count: 100

Registration Number: NCT06498115

Locations: 🇨🇳
The Third People's Hospital of Bengbu, Bengbu, Anhui, China

Leg Wrapping and Norepinephrine for Prevention of Post Spinal Hypotension in C.S

Phase 4

Not yet recruiting

Conditions: Post Spinal Hypotension

Interventions: Drug: Norepinephrine
Procedure: Leg wrapping

First Posted Date: 2024-07-11

Last Posted Date: 2024-07-11

Lead Sponsor: Fayoum University

Target Recruit Count: 168

Registration Number: NCT06496061

Locations: 🇪🇬
Fayoum University hospital, Madīnat Al Fayyūm, Faiyum Governorate, Egypt

Efficacy of Manual Toothbrushes in Removing Tooth Stains

Phase 3

Not yet recruiting

Conditions: Tooth Discoloration

Interventions: Drug: NaF
Drug: Na MFP

First Posted Date: 2024-07-05

Last Posted Date: 2024-07-05

Lead Sponsor: Colgate Palmolive

Target Recruit Count: 80

Registration Number: NCT06486974

Locations: 🇩🇴
Spa Dental, Santo Domingo, Dominican Republic

Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis

Phase 3

Recruiting

Conditions: Septic Shock

Interventions: Drug: Early Vasopressin
Drug: Norepinephrine and Vasopressin for Rescue

First Posted Date: 2024-06-18

Last Posted Date: 2025-03-20

Lead Sponsor: Hospital do Coracao

Target Recruit Count: 2800

Registration Number: NCT06464510

Locations: 🇧🇷
Hospital Geral de Caxias do Sul, Caxias do Sul, RS, Brazil
🇧🇷
Hospital Nereu Ramos, Florianópolis, Sc, Brazil
🇧🇷
Hospital de Amor - Unidade Barretos (Fundação PIO XII), Barretos, SP, Brazil

and more 5 locations

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