Clotrimazole

Generic Name
Clotrimazole
Brand Names
Alevazol, Dermacinrx Therazole Pak, Lotriderm, Lotrimin, Lotrimin AF, Lotrisone, Mycelex
Drug Type
Small Molecule
Chemical Formula
C22H17ClN2
CAS Number
23593-75-1
Unique Ingredient Identifier
G07GZ97H65
Background

This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s . Clotrimazole falls under the imidazole category of azole antifungals, possessing broad-spectrum antimycotic activity . It is available in various preparations, including creams, pessaries, and troche formulations (slowly di...

Indication

Topical preparations

Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections , :

Tinea pedis, tinea cruris, and tinea corporis due to Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum

Candidiasis due to Candida albicans

Tinea versicolor due to Malassezia furfur
...

Associated Conditions
Balanitis candida, Candidiasis, Dermatitis, Erythrasma, Fungal Vaginal Infections, Fungal ear infection, Fungal skin infection, Genital candidiasis, Inflammation, Mixed Vaginal Infections, Oropharyngeal Candidiasis, Pityriasis versicolor, Pyoderma, Ringworm, Skin Infections, Skin candida, Tinea Corporis, Tinea Cruris, Tinea Pedis, Tinea inguinalis, Trichophytosis, Vaginal Candidiasis, Vaginal Mycosis, Vulvitis, Cutaneous candidiasis, Infection mycotic, Susceptible Bacterial Infections, Symptomatic Tinea Corporis caused by Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum, Symptomatic Tinea Cruris caused by Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum, Symptomatic Tinea Pedis caused by Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum, Tinea versicolor caused by Malassezia infection
Associated Therapies
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B-Lymphocyte Immunotherapy in Islet Transplantation for Initial Islet Graft Failure

First Posted Date
2010-01-14
Last Posted Date
2014-06-11
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Registration Number
NCT01049633
Locations
🇺🇸

Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States

Efficacy and Safety Study of Miconazole Lauriad to Treat Oropharyngeal Candidiasis in HIV Patients

Phase 3
Completed
Conditions
Interventions
First Posted Date
2006-10-20
Last Posted Date
2013-09-16
Lead Sponsor
Valerio Therapeutics
Target Recruit Count
578
Registration Number
NCT00390780
Locations
🇨🇦

Montreal General Hospital, Montreal, Quebec, Canada

🇨🇦

University of Ottawa Health Services, Ottawa, Ontario, Canada

🇺🇸

University of Connecticut, School of dental medicine, Farmington, Connecticut, United States

and more 23 locations

Clotrimazole Enemas for Pouchitis in Children and Adults

First Posted Date
2003-05-26
Last Posted Date
2022-12-09
Lead Sponsor
Web
Target Recruit Count
11
Registration Number
NCT00061282
Locations
🇺🇸

Boston Children's Hospital, Boston, Massachusetts, United States

A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients With AIDS

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Pfizer
Registration Number
NCT00002282
Locations
🇺🇸

Dr Robert Larsen, Los Angeles, California, United States

🇺🇸

SUNY / Health Sciences Ctr at Stony Brook, Stony Brook, New York, United States

🇺🇸

Buckley Braffman Stern Med Associates, Philadelphia, Pennsylvania, United States

and more 14 locations

Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081)

Phase 3
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-02
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
500
Registration Number
NCT00000676
Locations
🇺🇸

Northwestern University CRS, Chicago, Illinois, United States

🇺🇸

Rush Univ. Med. Ctr. ACTG CRS, Chicago, Illinois, United States

🇺🇸

Bmc Actg Crs, Boston, Massachusetts, United States

and more 23 locations

Phase I/II Randomized Study of Hydroxyurea With or Without Clotrimazole in Patients With Sickle Cell Anemia

Phase 1
Completed
Conditions
First Posted Date
1999-10-19
Last Posted Date
2015-03-25
Lead Sponsor
University of North Carolina
Target Recruit Count
20
Registration Number
NCT00004492
Locations
🇺🇸

University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States

Study of Clotrimazole and Hydroxyurea in Patients With Sickle Cell Syndromes

Not Applicable
Completed
Conditions
First Posted Date
1999-10-19
Last Posted Date
2015-03-25
Lead Sponsor
Boston Children's Hospital
Target Recruit Count
20
Registration Number
NCT00004404
Locations
🇺🇸

Children's Hospital - Boston, Boston, Massachusetts, United States

🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

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