Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. In vitro...
For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in t...
Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania, United States
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Taipei, Taiwan
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Cancer Care of Western North Carolina, Asheville, North Carolina, United States
Moses Cone Regional Cancer Center at Wesley Long Community Hospital, Greensboro, North Carolina, United States
Marion L. Shepard Cancer Center, Washington, North Carolina, United States
Mount Carmel Hospital East, Columbus, Ohio, United States
Riverside Methodist Hospital, Columbus, Ohio, United States
Helen F Graham Cancer Center, Newark, Delaware, United States
Investigational Site Number 124011, Greenfield Park, Canada
Investigational Site Number 124010, Hamilton, Canada
Investigational Site Number 124008, Sudbury, Canada
The Hospital for Sick Children, Toronto, Ontario, Canada
Washington University School of Medicine, St. Louis, Missouri, United States
Scott & White Memorial Hospital And Clinic, Temple, Texas, United States
Texas Oncology, Dallas, Texas, United States
Usc/Norris Comprehensive Cancer Center, Los Angeles, California, United States
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