Remimazolam
- Generic Name
- Remimazolam
- Brand Names
- Byfavo
- Drug Type
- Small Molecule
- Chemical Formula
- C21H19BrN4O2
- CAS Number
- 308242-62-8
- Unique Ingredient Identifier
- 7V4A8U16MB
- Background
Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid biotransformation and elimination as inactive metabolites. These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/offset is desirable, enabling anesthesiologists to manipulate drug concentrations as needed. Remimazolam was the first "soft" benzodiazepine analog to be developed and was approved for use by the FDA in July 2020 under the brand name Byfavo.
- Indication
Remimazolam is indicated for the induction and maintenance of procedural sedation in adults undergoing procedures lasting 30 minutes or less.
- Associated Conditions
- Procedural Sedation
Dose of Remimazolam in Children for Intubation
- First Posted Date
- 2023-12-14
- Last Posted Date
- 2023-12-14
- Lead Sponsor
- Zhihong LU
- Target Recruit Count
- 40
- Registration Number
- NCT06170918
A Study of Remimazolam Tosilate for Sedation in the Upper Gastrointestinal Endoscopy
- Conditions
- Sedation in the Upper Gastrointestinal Endoscopy
- Interventions
- First Posted Date
- 2023-12-14
- Last Posted Date
- 2023-12-29
- Lead Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
- Target Recruit Count
- 31
- Registration Number
- NCT06169995
- Locations
- 🇨🇳
The Affiliated Hospital Of Guizhou Medical University, Guiyang, Guizhou, China
🇨🇳Sichuan Provincial People's Hospital, Chengdu, Sichuan, China
PK/PD Properties and Safety of Remazolam Besylate for Injection in ICU Patients With Impaired Renal Function
- First Posted Date
- 2023-12-01
- Last Posted Date
- 2023-12-13
- Lead Sponsor
- Wuhan Union Hospital, China
- Target Recruit Count
- 36
- Registration Number
- NCT06153498
- Locations
- 🇨🇳
Wuhan Union Hospital, Wuhan, Hubei, China
The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma
- Conditions
- Brain Network ConnectivityDexmedetomidinePropofolPostoperative Delirium
- Interventions
- First Posted Date
- 2023-11-18
- Last Posted Date
- 2025-02-14
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT06138340
- Locations
- 🇨🇳
Beijing Tian Tan Hospital, Capital Medical University, Beijing, Beijing, China
Comparison of Procedural Sedation in TEE
- First Posted Date
- 2023-11-13
- Last Posted Date
- 2025-03-11
- Lead Sponsor
- University of Alabama at Birmingham
- Target Recruit Count
- 120
- Registration Number
- NCT06129188
- Locations
- 🇺🇸
University of Alabama at Birmingham Hospital, Birmingham, Alabama, United States
Step 1 of A Two-step Trial to Evaluate the Effectiveness and Safety of Remimazolam Besylate for Sedation in ICU Patients
- First Posted Date
- 2023-11-09
- Last Posted Date
- 2024-02-05
- Lead Sponsor
- Wuhan Union Hospital, China
- Target Recruit Count
- 36
- Registration Number
- NCT06124404
- Locations
- 🇨🇳
Wuhan Union Hospital, Wuhan, Hubei, China
ED90 of Remimazolam Anesthesia Induction in Painless Bidirectional Endoscopy in Children
- First Posted Date
- 2023-11-08
- Last Posted Date
- 2024-10-26
- Lead Sponsor
- Tongji Hospital
- Target Recruit Count
- 114
- Registration Number
- NCT06121609
- Locations
- 🇨🇳
Tongji Hospital, Wuhan, Hubei, China
Remimazolam vs. Propofol: Impact on Postoperative Delirium in Neurosurgical Patients
- Conditions
- Postoperative Delirium
- Interventions
- First Posted Date
- 2023-11-02
- Last Posted Date
- 2024-04-17
- Lead Sponsor
- Samsung Medical Center
- Target Recruit Count
- 696
- Registration Number
- NCT06115031
- Locations
- 🇰🇷
Samsung Medical Center, Seoul, Korea, Republic of
Esketamine Combined With Remimazolam on Postoperative Sleep Disturbance and Anxiety in Patients
- Conditions
- Sleep Disturbance
- Interventions
- First Posted Date
- 2023-10-31
- Last Posted Date
- 2024-04-16
- Lead Sponsor
- Tianjin Medical University General Hospital
- Target Recruit Count
- 400
- Registration Number
- NCT06108830
- Locations
- 🇨🇳
Tianjin Medical University General Hospital, Tianjin, China
Remimazolam Versus Propofol for General Anesthesia Induction in Patients on Renin-angiotensin System Blockers Undergoing Robot-assisted Laparoscopic Prostatectomy
- First Posted Date
- 2023-10-23
- Last Posted Date
- 2024-12-12
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 112
- Registration Number
- NCT06093971
- Locations
- 🇰🇷
Yonsei University College of Medicine, Seoul, Korea, Republic of
Drug Development Updates
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