Simvastatin
- Generic Name
- Simvastatin
- Brand Names
- Cholib, FloLipid, Simcor, Vytorin, Zocor
- Drug Type
- Small Molecule
- Chemical Formula
- C25H38O5
- CAS Number
- 79902-63-9
- Unique Ingredient Identifier
- AGG2FN16EV
- Background
Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of Aspergillus terreus. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liv...
- Indication
Simvastatin is indicated for the treatment of hyperlipidemia to reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL‑C), apolipoprotein B (Apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C).
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- Associated Conditions
- Cardiovascular Events, Diabetes Mellitus, Heterozygous Familial Hypercholesterolemia (HeFH), High Cholesterol, Homozygous Familial Hypercholesterolaemia (HoFH), Mixed Hyperlipidemia, History of coronary heart disease cardiovascular event, History of stroke or other cerebrovascular disease cardiovascular event
- Associated Therapies
- -
Effect of Vitamin D Supplementation on Exercise Adaptations in Patients on Statin Therapy
- First Posted Date
- 2014-01-08
- Last Posted Date
- 2017-03-31
- Target Recruit Count
- 33
- Registration Number
- NCT02030041
- Locations
- 🇮🇳
PGIMER, Chandigarh, India
A Single Arm, Phase II Study of Simvastatin Plus XELOX and Bevacizumab as First-line Chemotherapy in Metastatic Colorectal Cancer Patients
- First Posted Date
- 2014-01-03
- Last Posted Date
- 2018-01-17
- Lead Sponsor
- Samsung Medical Center
- Target Recruit Count
- 43
- Registration Number
- NCT02026583
- Locations
- 🇰🇷
Samsung Medical Center, Seoul, Korea, Republic of
Sarilumab Effect on the Pharmacokinetics of Simvastatin
- Conditions
- Interventions
- First Posted Date
- 2013-12-23
- Last Posted Date
- 2016-04-07
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 19
- Registration Number
- NCT02017639
- Locations
- 🇺🇸
Investigational Site Number 840001, Dallas, Texas, United States
🇰🇷Investigational Site Number 410002, Seoul, Korea, Republic of
🇺🇸Investigational Site Number 840003, Jackson, Tennessee, United States
Simvastatin and Fenofibrate vs Simvastatin Alone in Patients With Type 2 Diabetes Mellitus and Acute Coronary Syndrome
- Conditions
- Interventions
- First Posted Date
- 2013-12-19
- Last Posted Date
- 2016-08-04
- Lead Sponsor
- Koval' O., MD
- Target Recruit Count
- 60
- Registration Number
- NCT02015988
- Locations
- 🇺🇦
State Institution "Dnipropetrovsk Medical Academy of Health Ministry of Ukraine", Dnipropetrovsk, Ukraine
Simvastatin Addition for Patients With Recent-onset Schizophrenia
- Conditions
- Interventions
- First Posted Date
- 2013-12-03
- Last Posted Date
- 2020-10-19
- Lead Sponsor
- Iris Sommer
- Target Recruit Count
- 121
- Registration Number
- NCT01999309
- Locations
- 🇳🇱
University Medical Center Groningen, Groningen, Netherlands
🇳🇱University Medical Center Utrecht, Utrecht, Netherlands
Effect of SSP-004184 (SPD602) on the Pharmacokinetics of Simvastatin in Healthy Adult Subjects
- First Posted Date
- 2013-11-08
- Last Posted Date
- 2021-06-24
- Lead Sponsor
- Shire
- Target Recruit Count
- 30
- Registration Number
- NCT01979185
- Locations
- 🇺🇸
Clinical Pharmacology of Miami, Inc., Miami, Florida, United States
A Study of Baricitinib and Simvastatin in Healthy Participants
- First Posted Date
- 2013-10-10
- Last Posted Date
- 2017-06-06
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 40
- Registration Number
- NCT01960140
- Locations
- 🇬🇧
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Leeds, West Yorkshire, United Kingdom
A Two-part Study to Investigate the Interaction and Pharmacokinetics of GSK2586184
- Conditions
- Interventions
- First Posted Date
- 2013-10-01
- Last Posted Date
- 2021-06-23
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 37
- Registration Number
- NCT01953835
- Locations
- 🇺🇸
GSK Investigational Site, Baltimore, Maryland, United States
Simvastatin for mTBI
- Conditions
- Interventions
- First Posted Date
- 2013-09-27
- Last Posted Date
- 2021-12-15
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 5
- Registration Number
- NCT01952288
- Locations
- 🇺🇸
VA Puget Sound Health Care System Seattle Division, Seattle, WA, Seattle, Washington, United States
Intensive Statin Therapy in Patients With AMI
- First Posted Date
- 2013-08-14
- Last Posted Date
- 2013-08-15
- Lead Sponsor
- Svendborg Hospital
- Target Recruit Count
- 140
- Registration Number
- NCT01923077
- Locations
- 🇩🇰
OUH/Svendborg Hospital, Svendborg, Funen, Denmark
Drug Development Updates
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