Simvastatin
- Generic Name
- Simvastatin
- Brand Names
- Cholib, FloLipid, Simcor, Vytorin, Zocor
- Drug Type
- Small Molecule
- Chemical Formula
- C25H38O5
- CAS Number
- 79902-63-9
- Unique Ingredient Identifier
- AGG2FN16EV
- Background
Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of Aspergillus terreus. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liv...
- Indication
Simvastatin is indicated for the treatment of hyperlipidemia to reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL‑C), apolipoprotein B (Apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C).
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- Associated Conditions
- Cardiovascular Events, Diabetes Mellitus, Heterozygous Familial Hypercholesterolemia (HeFH), High Cholesterol, Homozygous Familial Hypercholesterolaemia (HoFH), Mixed Hyperlipidemia, History of coronary heart disease cardiovascular event, History of stroke or other cerebrovascular disease cardiovascular event
- Associated Therapies
- -
Pharmacokinetics of Simvastatin and Its Metabolite Simvastatin Acid With and Without Concomitant Administration of Telmisartan in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2014-07-11
- Last Posted Date
- 2014-07-11
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 16
- Registration Number
- NCT02187536
Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patients
- First Posted Date
- 2014-07-11
- Last Posted Date
- 2023-01-30
- Lead Sponsor
- Mclean Hospital
- Target Recruit Count
- 227
- Registration Number
- NCT02188121
- Locations
- 🇺🇸
McLean Hospital, Belmont, Massachusetts, United States
The Effect of Multiple Oral Doses of BI 1356 BS on Pharmacokinetics, Safety and Tolerability of Multiple Oral Doses of Simvastatin and on the Pharmacokinetics of Its Metabolite Simvastatin Acid in Healthy Male Volunteers
- First Posted Date
- 2014-07-08
- Last Posted Date
- 2014-07-08
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 20
- Registration Number
- NCT02183623
Capecitabine Plus Simvastatin in Locally Advanced Rectal Cancer Patients
- First Posted Date
- 2014-06-12
- Last Posted Date
- 2020-03-25
- Lead Sponsor
- Samsung Medical Center
- Target Recruit Count
- 60
- Registration Number
- NCT02161822
- Locations
- 🇰🇷
Samsung Medical Center, Seoul, Korea, Republic of
A Study of Evacetrapib With Selected Statins in Healthy Chinese Participants
- Conditions
- Interventions
- First Posted Date
- 2014-06-05
- Last Posted Date
- 2018-10-10
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 62
- Registration Number
- NCT02156492
- Locations
- 🇨🇳
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Beijing, China
Simvastatin Effect on Portal Hypertension
- Conditions
- Interventions
- First Posted Date
- 2014-05-09
- Last Posted Date
- 2014-05-09
- Lead Sponsor
- Universidade Federal do Rio de Janeiro
- Target Recruit Count
- 34
- Registration Number
- NCT02134626
- Locations
- 🇧🇷
Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Detection and Prevention of Anthracycline-Related Cardiac Toxicity With Concurrent Simvastatin
- Conditions
- Interventions
- First Posted Date
- 2014-03-26
- Last Posted Date
- 2024-07-09
- Target Recruit Count
- 34
- Registration Number
- NCT02096588
- Locations
- 🇺🇸
Kimmel Cancer Center at Johns Hopkins at Sibley Memorial Hospital, Washington, District of Columbia, United States
🇺🇸Kimmel Cancer Center at Johns Hopkins, Baltimore, Maryland, United States
Efficacy of Simvastatin for the Treatment of COPD
- Conditions
- Interventions
- First Posted Date
- 2014-02-25
- Last Posted Date
- 2014-02-25
- Lead Sponsor
- Hospital Universitari Son Dureta
- Target Recruit Count
- 18
- Registration Number
- NCT02070133
- Locations
- 🇪🇸
Fundacio Caubet-CIMERA, Bunyola, Illes Balears, Spain
🇪🇸Hospital Son Espases, Palma Mallorca, Illes Balears, Spain
Clinical and Economic Outcome of Simvastatin in Critically Ill Septic Patient
- First Posted Date
- 2014-02-20
- Last Posted Date
- 2015-04-06
- Lead Sponsor
- sara mostafa amin eladawy
- Target Recruit Count
- 100
- Registration Number
- NCT02067949
- Locations
- 🇪🇬
Ain shams university hospital and cairo university hospital, Cairo, Egypt
Safety of Simvastatin in LAM and TSC
- Conditions
- Interventions
- First Posted Date
- 2014-02-12
- Last Posted Date
- 2020-08-25
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 10
- Registration Number
- NCT02061397
- Locations
- 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Drug Development Updates
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