Salbutamol

Generic Name
Salbutamol
Brand Names
Airomir, Airsupra, Combivent, Proair, Proventil, Ventolin
Drug Type
Small Molecule
Chemical Formula
C13H21NO3
CAS Number
18559-94-9
Unique Ingredient Identifier
QF8SVZ843E
Background

Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formulated as a racemic mixture of the R- and S-isomers. The R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer has been associated with toxicity. This lead to the development of levalbuterol, the single R-isomer of salbutamol. However, the high cost of levalbuterol compared to salbutamol has deterred wide-spread use of this enantiomerically pure version of the drug. Salbutamol is generally used for acute episodes of bronchospasm caused by bronchial asthma, chronic bronchitis and other chronic bronchopulmonary disorders such as chronic obstructive pulmonary disorder (COPD). It is also used prophylactically for exercise-induced asthma.

Indication

Salbutamol is indicated for (i) the symptomatic relief and prevention of bronchospasm due to bronchial asthma, chronic bronchitis, reversible obstructive airway disease, and other chronic bronchopulmonary disorders in which bronchospasm is a complicating factor, and/or (ii) the acute prophylaxis against exercise-induced bronchospasm and other stimuli known to induce bronchospasm.

Associated Conditions
Asthma, Asthmatic Bronchitis, Bronchial Asthma, Bronchoconstriction, Bronchospasm, Chronic Asthma, Chronic Bronchitis, Cough, Emphysema, Exacerbation of asthma, Exercise-Induced Bronchospasm, Hyperkalemia, Wheezing, Excess mucus or phlegm
Associated Therapies
Airway secretion clearance therapy, Bronchodilation

A Study of the Efficacy and Safety of NVA237 in Patients With Moderate to Severe COPD

First Posted Date
2015-02-25
Last Posted Date
2019-08-09
Lead Sponsor
Novartis Pharmaceuticals
Target Recruit Count
776
Registration Number
NCT02371629
Locations
🇸🇪

Novartis Investigative Site, Lund, Sweden

Ventilation-drive Coupling to Evaluate The Efficacy of Inhaled Bronchodilators in Patients With COPD

First Posted Date
2014-11-20
Last Posted Date
2015-07-28
Lead Sponsor
Zhujiang Hospital
Target Recruit Count
22
Registration Number
NCT02296047
Locations
🇨🇳

Zhujiang Hospital,Southern Medical Universtiy, Guangzhou, Guangdong, China

Bronchodilator Test in Mechanical Ventilated Chronic Obstructive Pulmonary Disease Patients

Not Applicable
Conditions
Interventions
First Posted Date
2014-08-18
Last Posted Date
2014-08-18
Lead Sponsor
Beijing Chao Yang Hospital
Target Recruit Count
120
Registration Number
NCT02218398
Locations
🇨🇳

Respiratory Intensive Care Unit, Beijing Chaoyang Hospital, Beijing, Beijing, China

Helium-3 MRI Imaging Study in COPD

First Posted Date
2014-08-04
Last Posted Date
2017-06-27
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
11
Registration Number
NCT02207452
Locations
🇬🇧

GSK Investigational Site, Sheffield, United Kingdom

Combivent vs. Salbutamol in Patients With Metacholine Induced Bronchospasm

First Posted Date
2014-07-08
Last Posted Date
2014-07-08
Lead Sponsor
Boehringer Ingelheim
Target Recruit Count
30
Registration Number
NCT02182713

Effectiveness of Routine Nebulization of Mucolytics and Bronchodilators During Mechanical Ventilation

First Posted Date
2014-06-09
Last Posted Date
2017-06-16
Lead Sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Target Recruit Count
950
Registration Number
NCT02159196
Locations
🇳🇱

Rijnstate Ziekenhuis, Arnhem, Netherlands

🇳🇱

MC Haaglanden, Den Haag, Netherlands

🇳🇱

Onze Lieve Vrouwe Gasthuis, Amsterdam, Noord Holland, Netherlands

and more 4 locations

The Various Effects of Gaseous Albuterol on Serum Lactate

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2014-02-27
Last Posted Date
2017-08-14
Lead Sponsor
University Medical Center of Southern Nevada
Target Recruit Count
28
Registration Number
NCT02073747
Locations
🇺🇸

University Medical Center of Southern Nevada, Las Vegas, Nevada, United States

Effectiveness Study of Integrative Treatment for Pediatric Pneumonia

First Posted Date
2014-02-24
Last Posted Date
2014-02-24
Lead Sponsor
Liaoning University of Traditional Chinese Medicine
Target Recruit Count
451
Registration Number
NCT02069665
Locations
🇨🇳

Affiliated Children's Hospital of Capital University of Medical Sciences, Beijing, Beijing, China

🇨🇳

Affiliated Children's Hospital of Dalian Medical University, Dalian, Liaoning, China

🇨🇳

Affiliated Hospital of Liaoning University of TCM, Shenyang, Liaoning, China

and more 3 locations

Inhaled Salbutamol in Elective Caesarean Section

First Posted Date
2013-11-07
Last Posted Date
2014-12-08
Lead Sponsor
Sture Andersson
Target Recruit Count
62
Registration Number
NCT01978418
Locations
🇫🇮

Women's Hospital, Helsinki, Finland

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