Gentamicin
- Generic Name
- Gentamicin
- Brand Names
- Gentak, Pred-G, Valisone-G
- Drug Type
- Small Molecule
- Chemical Formula
- C60H123N15O21
- CAS Number
- 1403-66-3
- Unique Ingredient Identifier
- T6Z9V48IKG
- Background
Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from Micromonospora purpurea in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability. Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment ...
- Indication
1.本品适用于敏感铜绿假单胞菌、变形杆菌（吲哚阳性和阴性）属、大肠埃希菌、克雷伯菌属、肠杆菌属、沙雷菌属、柠檬酸杆菌属以及葡萄球菌属（不包括耐甲氧西林菌株）所致的严重感染；临床上本品常与β内酰胺类或其他抗菌药物联合应用。本品与青霉素G（或氨苄西林）联合应用治疗肠球菌感染；
2.本品用于铜绿假单胞菌或葡萄球菌属所致的严重中枢神经系统感染（如脑膜炎、脑室炎）时，可同时用本品鞘内注射作为辅助治疗；
3.本品不适用于单纯性尿路感染初治，除非病原菌对其他毒性较低的抗菌药物不敏感，本品对链球菌属中多数菌种（尤其D组）、肺炎链球菌和厌氧菌（如拟杆菌属或梭状芽孢杆菌属）无效；
4.本品口服可用于肠道感染或结肠手术前准备，也可用本品肌注合并克林霉素或甲硝唑以减少结肠手术后感染率。
...
- Associated Conditions
- Allergic Conjunctivitis (AC), Bacterial Conjunctivitis, Bacterial Infections, Bacterial Keratitis, Bacterial Peritonitis, Bacterial dacryocystitis, Blepharoconjunctivitis, Central Nervous System Infections, Corneal infection, Dermatitis infected, Ecthyma, Eczematous dermatitis infected, Folliculitis, Furunculosis, Gram-negative enteric bacilli neonatal sepsis, Impetigo contagious, Inflammation, Keratoconjunctivitis, Meibomianitis, Meningitis, Bacterial, Ocular Inflammation, Pustular Psoriasis (PP), Pustular acne, Pyoderma Gangrenosum, Seborrheic Dermatitis, Septicemia gram-negative, Skin Infections, Skin and Subcutaneous Tissue Bacterial Infections, Sycosis barbae, Bacterial blepharitis, Bacterial corneal ulcers, Bacterial skin infections, Complicated Respiratory tract infection bacterial, Complicated Urinary Tract Infection caused by susceptible bacteria, Corticosteroid-responsive dermatoses, Ocular bacterial infections, Severe Endocarditis enterococcal, Severe Infection Pseudomonas aeruginosa, Severe Staphylococcal infection
- Associated Therapies
- -
Vestibular Rehabilitation With Intratympanic Drug Therapy in Meniere's Disease
- Conditions
- Interventions
- First Posted Date
- 2022-05-02
- Last Posted Date
- 2022-05-02
- Lead Sponsor
- Combined Military Hospital Quetta
- Target Recruit Count
- 93
- Registration Number
- NCT05355610
- Locations
- 🇵🇰
CMH Quetta, Quetta, Balochistan, Pakistan
The Immunostimulatory Effects of Gentamicin
- First Posted Date
- 2022-03-31
- Last Posted Date
- 2024-05-16
- Lead Sponsor
- Singapore General Hospital
- Target Recruit Count
- 33
- Registration Number
- NCT05303909
- Locations
- 🇸🇬
Singapore General Hospital, Singapore, Singapore
Effects of Topical Gentamicin on the Prevention of Peritoneal Dialysis Related Infection
- Conditions
- Interventions
- First Posted Date
- 2022-02-22
- Last Posted Date
- 2022-02-22
- Lead Sponsor
- Phramongkutklao College of Medicine and Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT05251584
- Locations
- 🇹🇭
Phramongkutklao Hospital, Ratchathewi, Bangkok, Thailand
Gentamicin Open Tibia Study
- First Posted Date
- 2021-12-14
- Last Posted Date
- 2023-12-21
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 890
- Registration Number
- NCT05157126
- Locations
- 🇹🇿
Muhimbili Orthopaedic Institute, Dar es Salaam, Tanzania
Strategies to Reduce Mortality Among HIV-infected and HIV-exposed Children Admitted With Severe Acute Malnutrition
- Conditions
- Interventions
- First Posted Date
- 2021-09-21
- Last Posted Date
- 2021-09-30
- Lead Sponsor
- Makerere University
- Target Recruit Count
- 300
- Registration Number
- NCT05051163
- Locations
- 🇺🇬
Makerere University College of Health Sciences, Kampala, Central, Uganda
Safety, Tolerability, Pharmacokinetics and Efficacy of Twice Daily Application of Topical BioLexa in Adult Healthy Subjects and Patients With Mild to Moderate Atopic Dermatitis
- Conditions
- Interventions
- First Posted Date
- 2020-09-10
- Last Posted Date
- 2022-11-17
- Lead Sponsor
- Hoth Therapeutics, Inc.
- Target Recruit Count
- 31
- Registration Number
- NCT04544943
- Locations
- 🇦🇺
Novatrials, Kotara, New South Wales, Australia
Frequency of Surgical Site Infection in Abdominal Hernia With Gentamycin Spray on Mesh Versus no Spray
- First Posted Date
- 2019-11-15
- Last Posted Date
- 2019-11-20
- Lead Sponsor
- Dow University of Health Sciences
- Target Recruit Count
- 80
- Registration Number
- NCT04164524
- Locations
- 🇵🇰
Professor Shahida Parveen Afridi, Karachi, Sindh, Pakistan
Ciprofloxacin Versus an Aminoglycoside Followed by Ciprofloxacin for Bubonic Plague
- Conditions
- Interventions
- First Posted Date
- 2019-10-01
- Last Posted Date
- 2024-06-17
- Lead Sponsor
- University of Oxford
- Target Recruit Count
- 463
- Registration Number
- NCT04110340
- Locations
- 🇲🇬
Professor Mamy Randria, Antananarivo, Madagascar
NICU Antibiotics and Outcomes Trial
- First Posted Date
- 2019-06-25
- Last Posted Date
- 2024-01-17
- Lead Sponsor
- Michael Morowitz
- Target Recruit Count
- 802
- Registration Number
- NCT03997266
- Locations
- 🇺🇸
Pennsylvania Hospital/The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
🇺🇸Alfred I. duPont for Children of the Nemours Foundation, Philadelphia, Pennsylvania, United States
🇺🇸Magee Womens Hospital, Pittsburgh, Pennsylvania, United States
Intravenous Gentamicin Therapy for Recessive Dystrophic Epidermolysis Bullosa (RDEB)
- First Posted Date
- 2018-01-08
- Last Posted Date
- 2022-11-03
- Lead Sponsor
- University of Southern California
- Target Recruit Count
- 9
- Registration Number
- NCT03392909
- Locations
- 🇺🇸
University of Southern California, Los Angeles, California, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.