Lisinopril

Generic Name: Lisinopril

Brand Names: Prinivil, Qbrelis, Zestoretic, Zestril

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₃₁N_₃O_₅

CAS Number: 76547-98-3

Unique Ingredient Identifier: 7Q3P4BS2FD

Background: Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction. Lisinopril and captopril are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system. ACEIs are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.

Lisinopril was granted FDA approval on 29 December 1987.

Indication: Lisinopril is indicated for the treatment of acute myocardial infarction, hypertension in patients ≥6 years, and as an adjunct therapy for heart failure. A combination product with hydrochlorothiazide is indicated for the treatment of hypertension.

Associated Conditions: Acute Myocardial Infarction (AMI), Cardiovascular Events, Congestive Heart Failure (CHF), Diabetic Nephropathy, Hypertension, Migraine

Clinical Trials

Women With Chest Pain and Normal Coronary Arteries Study

Not Applicable

Terminated

Conditions: Chest Pain

Interventions: Drug: Aspirin
Drug: Lisinopril
Drug: Simvastatin
Drug: Lovaza
Behavioral: Therapeutic Lifestyle Changes

First Posted Date: 2008-08-28

Last Posted Date: 2023-12-12

Lead Sponsor: Northwestern University

Target Recruit Count: 3

Registration Number: NCT00743197

Locations: 🇺🇸
Northwestern University, Chicago, Illinois, United States

Black Education and Treatment of Hypertension (BEAT HTN)

Phase 4

Completed

Conditions: Hypertension

Interventions: Drug: Hydrochlorothiazide
Drug: Lisinopril
Drug: Lisinopril and Hydrochlorothiazide
Drug: Nifedipine XL
Drug: Metoprolol tartrate
Drug: Atenolol
Drug: Valsartan
Drug: Doxazosin
Drug: Clonidine
Drug: Hydralazine
Drug: Metoprolol succinate
Drug: Amlodipine

First Posted Date: 2008-04-21

Last Posted Date: 2012-12-04

Lead Sponsor: Creighton University

Target Recruit Count: 99

Registration Number: NCT00661895

Locations: 🇺🇸
Creighton Community Health Center, Omaha, Nebraska, United States

Research Study To Test Carvedilol CR + Lisinopril Versus Lisinopril + Placebo In Patients With High Blood Pressure

Phase 3

Completed

Conditions: Hypertension

Interventions: Drug: lisinopril + placebo
Drug: carvedilol controlled release/lisinopril

First Posted Date: 2008-02-26

Last Posted Date: 2016-12-28

Lead Sponsor: GlaxoSmithKline

Target Recruit Count: 348

Registration Number: NCT00624065

Locations: 🇺🇸
GSK Investigational Site, Beloit, Wisconsin, United States

The Antihypertensives and Vascular, Endothelial and Cognitive Function Trial

Phase 2

Completed

Conditions: Cognitive Impairment
Hypertension
Aging

Interventions: Drug: hydrochlorothiazide
Drug: candesartan
Drug: lisinopril
Drug: nifedipine, long acting
Drug: metoprolol, long-acting

First Posted Date: 2008-01-30

Last Posted Date: 2013-02-15

Lead Sponsor: University of Southern California

Target Recruit Count: 53

Registration Number: NCT00605072

Locations: 🇺🇸
Hebrew SeniorLife, Boston, Massachusetts, United States
🇺🇸
University of Southern California, Los Angeles, California, United States

Hypertension in Hemodialysis Patients (Aim 3)

Phase 3

Terminated

Conditions: Left Ventricular Hypertrophy
Hemodialysis
Hypertension

Interventions: Drug: Lisinopril
Drug: Atenolol

First Posted Date: 2007-12-28

Last Posted Date: 2016-01-18

Lead Sponsor: Indiana University

Target Recruit Count: 200

Registration Number: NCT00582114

Locations: 🇺🇸
Indiana University, Indianapolis, Indiana, United States

VA NEPHRON-D: Diabetes iN Nephropathy Study

Phase 3

Terminated

Conditions: Kidney Disease
Nephropathy
Type 2 Diabetes

Interventions: Drug: losartan
Drug: lisinopril

First Posted Date: 2007-11-08

Last Posted Date: 2015-05-29

Lead Sponsor: US Department of Veterans Affairs

Target Recruit Count: 1448

Registration Number: NCT00555217

Locations: 🇺🇸
VA Palo Alto Health Care System, Palo Alto, California, United States
🇵🇷
VA Medical Center, San Juan, San Juan, Puerto Rico
🇺🇸
VA Medical Center, Memphis, Memphis, Tennessee, United States

and more 28 locations