Lisinopril

Generic Name
Lisinopril
Brand Names
Prinivil, Qbrelis, Zestoretic, Zestril
Drug Type
Small Molecule
Chemical Formula
C21H31N3O5
CAS Number
76547-98-3
Unique Ingredient Identifier
7Q3P4BS2FD
Background

Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction. Lisinopril and captopril are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system. ACEIs are commonly used as a first line therap...

Indication

Lisinopril is indicated for the treatment of acute myocardial infarction, hypertension in patients ≥6 years, and as an adjunct therapy for heart failure. A combination product with hydrochlorothiazide is indicated for the treatment of hypertension.

Associated Conditions
Acute Myocardial Infarction (AMI), Cardiovascular Events, Congestive Heart Failure (CHF), Diabetic Nephropathy, Hypertension, Migraine
Associated Therapies
-
Clinical Trials
Related News

Antiproteinuric Effect of Valsartan and Lisinopril

Phase 4
Completed
Conditions
Hypertension
Diabetic Nephropathy
First Posted Date
2005-09-15
Last Posted Date
2017-02-24
Lead Sponsor
Novartis
Target Recruit Count
124
Registration Number
NCT00171574
Locations
🇨🇭

Novartis Pharmaceuticals, Basel, Switzerland

COREG MR Versus TOPROL-XL On Reduction Of Microalbuminuria In Patients With Hypertension And Microalbuminuria

First Posted Date
2005-07-26
Last Posted Date
2017-01-18
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
1220
Registration Number
NCT00123903
Locations
🇵🇷

GSK Investigational Site, San Juan, Puerto Rico

Maximal Dose of Angiotensin Converting Enzyme (ACE) Inhibitor for Treatment of Diabetic Kidney Disease

Not Applicable
Completed
Conditions
Diabetes Mellitus, Type I
Diabetic Nephropathy
First Posted Date
2005-07-12
Last Posted Date
2006-11-23
Lead Sponsor
Steno Diabetes Center Copenhagen
Target Recruit Count
60
Registration Number
NCT00118976
Locations
🇩🇰

Steno Diabetes Center, Gentofte, Denmark

The CLEVER Study - Coreg And Left Ventricular Mass Regression

First Posted Date
2005-04-14
Last Posted Date
2016-12-16
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
287
Registration Number
NCT00108082
Locations
🇺🇸

GSK Investigational Site, Milwaukee, Wisconsin, United States

Genetics of Hypertension Associated Treatments (GenHAT)

First Posted Date
2000-09-26
Last Posted Date
2024-04-26
Lead Sponsor
Donna Arnett, 257-5678
Target Recruit Count
37939
Registration Number
NCT00006294
Locations
🇺🇸

University of Kentucky, Lexington, Kentucky, United States

Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

First Posted Date
1999-10-28
Last Posted Date
2016-07-29
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Registration Number
NCT00000542

Drugs for High Blood Pressure and High Cholesterol in American Indians With Type 2 Diabetes

First Posted Date
1999-10-19
Last Posted Date
2018-03-07
Lead Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Target Recruit Count
160
Registration Number
NCT00004266
Locations
🇺🇸

Hennepin County Medical Center, Minneapolis, Minnesota, United States

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