Nicardipine

Generic Name: Nicardipine

Brand Names: Cardene

Drug Type: Small Molecule

Chemical Formula: C_₂₆H_₂₉N_₃O_₆

CAS Number: 55985-32-5

Unique Ingredient Identifier: CZ5312222S

Background: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]

Indication: Used for the management of patients with chronic stable angina and for the treatment of hypertension.

Associated Conditions: Chronic Stable Angina Pectoris, Hypertension, Migraine, Blood pressure >185/110 mm Hg arterial hypertension

Associated Therapies: -

Clinical Trials

Hypotensive Anesthesia for Orthognathic Surgery

Phase 4

Not yet recruiting

Conditions: Hypotensive Anesthesia
Orthognathic Surgery

Interventions: Drug: Dexmedetomidine
Drug: Nicardipine
Drug: Labetalol

First Posted Date: 2023-10-23

Last Posted Date: 2024-12-05

Lead Sponsor: Boston Medical Center

Target Recruit Count: 90

Registration Number: NCT06093893

Locations: 🇺🇸
Boston Medical Center, Boston, Massachusetts, United States

Effects of Subcutaneously Infiltrated Nicardipine on the Success Rate of Radial Artety Cannulation

Not Applicable

Conditions: Radial Artery Cannulation

Interventions: Other: Normal saline
Drug: Nicardipine

First Posted Date: 2023-06-27

Last Posted Date: 2023-06-27

Lead Sponsor: Mahidol University

Target Recruit Count: 190

Registration Number: NCT05920538

Locations: 🇹🇭
Anesthesiology Department, Bangkok, Thailand

Dilution of Verapamil During Intraarterial Administration

Early Phase 1

Completed

Conditions: Vasospasm;Peripheral
Burning
Pain

Interventions: Drug: Verapamil
Drug: Nicardipine

First Posted Date: 2022-11-23

Last Posted Date: 2024-11-27

Lead Sponsor: University of Illinois at Chicago

Target Recruit Count: 55

Registration Number: NCT05625503

Locations: 🇺🇸
University of Illinois Hospital, Chicago, Illinois, United States

Relationship Between Perioperative Carotid Blood Flow Monitoring and Cerebral Function Protection in Cardiac Surgery

Not Applicable

Completed

Conditions: Coronary Artery Bypass Grafting
Cardiopulmonary Bypass

Interventions: Other: normal saline
Drug: Nicardipine

First Posted Date: 2022-10-19

Last Posted Date: 2022-10-19

Lead Sponsor: Nanjing First Hospital, Nanjing Medical University

Target Recruit Count: 64

Registration Number: NCT05586347

Locations: 🇨🇳
Hongwei Shi, Nanjing, Jiangsu, China

Nicardipine to Avoid Spasm in Trans Radial Percutaneous Coronary Intervention

Phase 3

Completed

Conditions: Spasm Artery

Interventions: Drug: Nicardipine

First Posted Date: 2020-09-04

Last Posted Date: 2022-02-08

Lead Sponsor: Pr. Semir Nouira

Target Recruit Count: 1500

Registration Number: NCT04538534

Locations: 🇹🇳
CHU Fattouma Bourguiba, Monastir, Tunisia

A Safety and Efficacy Study of NicaPlant® in Aneurysmal Subarachnoid Haemorrhage Patients Undergoing Aneurysm Clipping

Phase 2

Completed

Conditions: Aneurysmal Subarachnoid Hemorrhage

Interventions: Drug: Nicardipine
Other: Standard of care

First Posted Date: 2020-02-13

Last Posted Date: 2023-07-12

Lead Sponsor: BIT Pharma GmbH

Target Recruit Count: 41

Registration Number: NCT04269408

Locations: 🇦🇹
Kepler Universitätsklinikum, Universitätsklinik für Neurochirurgie, Linz, Austria
🇦🇹
Universitätsklinik Innsbruck, Universitätsklinik für Neurochirurgie, Innsbruck, Austria
🇩🇪
Universitätsklinikum Göttingen, Neurochirurgische Klinik, Göttingen, Germany

and more 3 locations

Blood Pressure After Endovascular Stroke Therapy-II

Phase 2

Completed

Conditions: Endovascular Thrombectomy
Acute Stroke

Interventions: Drug: Nicardipine
Drug: Labetalol
Drug: Hydralazine

First Posted Date: 2019-10-04

Last Posted Date: 2023-10-12

Lead Sponsor: University of Cincinnati

Target Recruit Count: 120

Registration Number: NCT04116112

Locations: 🇺🇸
Hartford Healthcare, Hartford, Connecticut, United States
🇺🇸
University of Cincinnati, Cincinnati, Ohio, United States
🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

Effects of Different Kinds of Hypotensive Drugs on Dynamic Hemodynamic Changing in Patients Under Surgeries

Not Applicable

Completed

Conditions: General Surgery

Interventions: Drug: Urapidil
Drug: Nicardipine

First Posted Date: 2018-04-13

Last Posted Date: 2020-08-26

Lead Sponsor: Chinese PLA General Hospital

Target Recruit Count: 59

Registration Number: NCT03497351

Locations: 🇨🇳
Chinese PLA General Hospital, Beijing, Haidian, China

Prevention of Coronary Microvascular Dysfunction Post-PCI by Intracoronary Nicardipine

Early Phase 1

Withdrawn

Conditions: Coronary Artery Disease

Interventions: Drug: Sterile Saline
Drug: Nicardipine

First Posted Date: 2017-06-12

Last Posted Date: 2024-04-26

Lead Sponsor: Thomas Jefferson University

Registration Number: NCT03184155

Locations: 🇺🇸
Thomas Jefferson University, Philadelphia, Pennsylvania, United States

The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine

Phase 3

Terminated

Conditions: Hypertension
Preeclampsia

Interventions: Drug: Urapidil
Drug: Nicardipine

First Posted Date: 2015-09-23

Last Posted Date: 2020-08-25

Lead Sponsor: University Hospital, Strasbourg, France

Target Recruit Count: 14

Registration Number: NCT02558023

Locations: 🇫🇷
Service d'Anesthésie - CMCO, Schiltigheim, France
🇫🇷
Service d'Anesthésie et de Réanimation Médicale, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

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