Varenicline
- Generic Name
- Varenicline
- Brand Names
- Champix, Chantix, Tyrvaya
- Drug Type
- Small Molecule
- Chemical Formula
- C13H13N3
- CAS Number
- 249296-44-4
- Unique Ingredient Identifier
- W6HS99O8ZO
- Background
Varenicline is a prescription medication used to treat smoking addiction. This medication is the first approved nicotinic receptor partial agonist. Specifically, varenicline is a partial agonist of the alpha4/beta2 subtype of the nicotinic acetylcholine receptor. In addition it acts on alpha3/beta4 and weakly on alpha3beta2 and alpha6-containing receptors. A...
- Indication
For use as an aid in smoking cessation.
Varenicline as a nasal spray is indicated for the symptomatic treatment of dry eye disease.
- Associated Conditions
- Dry Eye Syndrome (DES)
- Associated Therapies
- Smoking, Cessation
Smoking Cessation Intervention for Thoracic Patients
- Conditions
- Interventions
- First Posted Date
- 2007-12-24
- Last Posted Date
- 2018-10-12
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 49
- Registration Number
- NCT00580398
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
Chantix for Treating Cocaine Dependence
- First Posted Date
- 2007-12-04
- Last Posted Date
- 2013-11-07
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 37
- Registration Number
- NCT00567008
- Locations
- 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Efficacy of Varenicline in Methadone-Stabilized Cocaine Users
- Conditions
- Interventions
- First Posted Date
- 2007-12-04
- Last Posted Date
- 2020-04-02
- Lead Sponsor
- Yale University
- Target Recruit Count
- 31
- Registration Number
- NCT00567320
- Locations
- 🇺🇸
Veterans Hopsital, West Haven, Connecticut, United States
Comparison of Varenicline and Placebo for Smoking Cessation in Schizophrenia
- First Posted Date
- 2007-11-07
- Last Posted Date
- 2022-03-18
- Lead Sponsor
- University of Maryland, Baltimore
- Target Recruit Count
- 16
- Registration Number
- NCT00554840
Varenicline Effects In Schizophrenic Smokers
- Conditions
- Interventions
- First Posted Date
- 2007-10-24
- Last Posted Date
- 2018-09-20
- Lead Sponsor
- Nathan Kline Institute for Psychiatric Research
- Target Recruit Count
- 14
- Registration Number
- NCT00548470
- Locations
- 🇺🇸
Manhattan Psychiatric Center, New York, New York, United States
Mood and Anti-craving Effects of Varenicline in Psychiatric Inpatients
- Conditions
- First Posted Date
- 2007-09-06
- Last Posted Date
- 2015-07-21
- Lead Sponsor
- Butler Hospital
- Registration Number
- NCT00525928
- Locations
- 🇺🇸
Butler Hospital, Providence, Rhode Island, United States
Study of Mood Effects of Varenicline (Chantix) in Depressed Outpatient Smokers
- Conditions
- Interventions
- First Posted Date
- 2007-09-06
- Last Posted Date
- 2018-11-28
- Lead Sponsor
- Butler Hospital
- Target Recruit Count
- 18
- Registration Number
- NCT00525837
- Locations
- 🇺🇸
Butler Hospital, Providence, Rhode Island, United States
Pharmacogenetics, Emotional Reactivity and Smoking
- Conditions
- Interventions
- First Posted Date
- 2007-07-26
- Last Posted Date
- 2021-05-06
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 646
- Registration Number
- NCT00507728
- Locations
- 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette Smokers
- First Posted Date
- 2007-07-17
- Last Posted Date
- 2018-01-17
- Lead Sponsor
- Yale University
- Target Recruit Count
- 40
- Registration Number
- NCT00502216
- Locations
- 🇺🇸
Yale University School of Medicine Substance Abuse Treatment Unit, New Haven, Connecticut, United States
Varenicline Adjunctive Treatment in Schizophrenia
- Conditions
- Interventions
- First Posted Date
- 2007-06-27
- Last Posted Date
- 2022-01-05
- Lead Sponsor
- University of Maryland, Baltimore
- Target Recruit Count
- 91
- Registration Number
- NCT00492349
- Locations
- 🇺🇸
UMB School of Medicine, Baltimore, Maryland, United States
🇺🇸University of Maryland Medical System, Baltimore, Maryland, United States
🇺🇸Maryland Psychiatric Research Center, Baltimore, Maryland, United States
Drug Development Updates
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