Nebivolol

Generic Name
Nebivolol
Brand Names
Bystolic
Drug Type
Small Molecule
Chemical Formula
C22H25F2NO4
CAS Number
118457-14-0
Unique Ingredient Identifier
030Y90569U
Background

Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than atenolol, propranolol, or pindolol. Nebivolol and other beta blockers are generally not first l...

Indication

Nebivolol is indicated to treat hypertension.

Associated Conditions
Hypertension
Associated Therapies
-

Nebivolol, Lifestyle Modification and Arterial Stiffness

First Posted Date
2013-08-09
Last Posted Date
2018-02-23
Lead Sponsor
Virginia Polytechnic Institute and State University
Target Recruit Count
45
Registration Number
NCT01920282

Nebivolol Effects on Endothelial Function and Erectile Function

First Posted Date
2013-06-25
Last Posted Date
2013-06-25
Lead Sponsor
Martin M. Miner, MD
Target Recruit Count
70
Registration Number
NCT01885988
Locations
🇺🇸

University Medicine, Providence, Rhode Island, United States

🇺🇸

Miriam Cardiology, Providence, Rhode Island, United States

🇺🇸

The Miriam Hospital / The Men's Health Center, Providence, Rhode Island, United States

CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients.

First Posted Date
2013-01-18
Last Posted Date
2013-01-18
Lead Sponsor
Universitaire Ziekenhuizen KU Leuven
Target Recruit Count
36
Registration Number
NCT01771406
Locations
🇧🇪

University Hospitals Leuven, Leuven, Belgium

Economic Impact of Switching From Metoprolol to Nebivolol for Hypertension Treatment

First Posted Date
2013-01-01
Last Posted Date
2013-01-01
Lead Sponsor
Forest Laboratories
Target Recruit Count
3000
Registration Number
NCT01758263
Locations
🇺🇸

Forest Investigative Site 0, Jersey City, New Jersey, United States

The Effects of Nebivolol on the NO-system in Patients With Essential Hypertension

Phase 2
Completed
Conditions
Interventions
First Posted Date
2012-09-06
Last Posted Date
2014-03-04
Lead Sponsor
Erling Bjerregaard Pedersen
Target Recruit Count
25
Registration Number
NCT01679652
Locations
🇩🇰

Department of Medical Research, Holstebro Hospital, Holstebro, Denmark

Study to Evaluate Effect of Nebivolol on Angina in Women With Microvascular Disease

Phase 4
Completed
Conditions
Interventions
First Posted Date
2012-08-15
Last Posted Date
2017-04-20
Lead Sponsor
Massachusetts General Hospital
Target Recruit Count
12
Registration Number
NCT01665508
Locations
🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

Nebivolol for the Prevention of Left Ventricular Systolic Dysfunction in Patients With Duchenne Muscular Dystrophy

First Posted Date
2012-07-24
Last Posted Date
2021-09-28
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
51
Registration Number
NCT01648634
Locations
🇫🇷

Armand Trousseau Hospital, Paris, France

Can Nebivolol Reverse Inappropriate Left Ventricular Mass in Hypertensive Patients?

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2012-05-24
Last Posted Date
2014-05-19
Lead Sponsor
Mayo Clinic
Target Recruit Count
1
Registration Number
NCT01605370
Locations
🇺🇸

Mayo Clinic Arizona, Scottsdale, Arizona, United States

Nebivolol and Endothelial Regulation of Fibrinolysis (NERF)

First Posted Date
2012-05-10
Last Posted Date
2019-06-25
Lead Sponsor
University of Colorado, Boulder
Target Recruit Count
44
Registration Number
NCT01595516
Locations
🇺🇸

UC-Boulder Clinical and Translational Research Center, Boulder, Colorado, United States

A Study Examining the Effects of Nebivolol Compared to Atenolol on Endothelial Function

Phase 2
Completed
Conditions
Interventions
First Posted Date
2012-02-01
Last Posted Date
2020-07-17
Lead Sponsor
University of Minnesota
Target Recruit Count
76
Registration Number
NCT01522950
Locations
🇺🇸

University of Minnesota, Minneapolis, Minnesota, United States

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