Clonidine
- Generic Name
- Clonidine
- Brand Names
- Catapres, Catapres-TTS, Catapres-tts-1, Duraclon, Kapvay, Nexiclon XR
- Drug Type
- Small Molecule
- Chemical Formula
- C9H9Cl2N3
- CAS Number
- 4205-90-7
- Unique Ingredient Identifier
- MN3L5RMN02
- Background
Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.
Clonidine was granted FDA approval on 3 September 1974.
- Indication
Clonidine tablets and transdermal systems are indicated for the treatment of hypertension alone or in combination with other medications. A clonidine injection is indicated for use with opiates in the treatment of severe cancer pain where opiates alone are insufficient. An extended release tablet of clonidine is indicated for the treatment of ADHD either alo...
- Associated Conditions
- Attention Deficit Hyperactivity Disorder (ADHD), Defiant Disorder, Oppositional, Gilles de la Tourette's Syndrome, Hot Flashes, Human Growth Hormone Deficiency, Hypertension, Opioid Withdrawal (Disorder), Pheochromocytoma, Postherpetic Neuralgia, Sialorrhea caused by clozapine, Diabetic diarrhea, Methadone withdrawal, Severe Cancer pain
- Associated Therapies
- Smoking, Cessation
Regional Anesthesia EMG Study
- Conditions
- Interventions
- First Posted Date
- 2024-02-29
- Last Posted Date
- 2024-02-29
- Lead Sponsor
- Nationwide Children's Hospital
- Target Recruit Count
- 124
- Registration Number
- NCT06287151
- Locations
- 🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States
A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats
- Conditions
- Interventions
- Drug: FezolinetantDrug: ParoxetineDrug: GabapentinDrug: CitalopramDrug: ClonidineDrug: PregabalinDrug: EscitalopramDrug: DesvenlafaxineDrug: OxybutyninDrug: Any other non-hormonal pharmacologic therapy prescribed for the treatment of VMS not included in a category aboveDrug: VenlafaxineDrug: Any other SSRI/SNRI not already specified
- First Posted Date
- 2023-09-22
- Last Posted Date
- 2024-12-17
- Lead Sponsor
- Astellas Pharma Global Development, Inc.
- Target Recruit Count
- 1000
- Registration Number
- NCT06049797
- Locations
- 🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States
🇺🇸SUNY Downstate Health Sciences University, Brooklyn, New York, United States
🇺🇸Mohawk Valley Health System - Womens Health Center, Utica, New York, United States
Efficacy of Intrathecal Clonidine Versus Neostigmine as Adjuvants to Bupivacaine on Postoperative Maternal and Fetal Outcomes After Elective Cesarean Section
- First Posted Date
- 2023-07-13
- Last Posted Date
- 2023-07-13
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 111
- Registration Number
- NCT05943613
Clonidine With Morphine in Patient Controlled Analgesia Pump in Vaso-Occlusive Crisis in Sickle Cell Disease Patient
- Conditions
- Interventions
- First Posted Date
- 2023-05-08
- Last Posted Date
- 2023-05-08
- Lead Sponsor
- Centre Hospitalier Universitaire Saint Pierre
- Target Recruit Count
- 40
- Registration Number
- NCT05848531
- Locations
- 🇧🇪
CHU Saint-Pierre, Bruxelles, Belgium
Clonidine for Infra-orbital Nerve Block During Pediatric Cleft Lip Revision Surgeries
- Conditions
- Interventions
- First Posted Date
- 2023-03-29
- Last Posted Date
- 2023-08-22
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 86
- Registration Number
- NCT05790044
Consciousness, Psilocybin, and Well-Being
- Conditions
- Interventions
- First Posted Date
- 2022-10-24
- Last Posted Date
- 2024-10-15
- Lead Sponsor
- University of Wisconsin, Madison
- Target Recruit Count
- 23
- Registration Number
- NCT05592379
- Locations
- 🇺🇸
University of Wisconsin Hospital and Clinics, Madison, Wisconsin, United States
Intraoperative Clonidine for Postoperative Pain Management in Patients Undergoing Surgical Treatment for Endometriosis
- Conditions
- Interventions
- First Posted Date
- 2022-09-29
- Last Posted Date
- 2024-08-23
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 120
- Registration Number
- NCT05560230
- Locations
- 🇩🇰
Aarhus University Hospital, Aarhus, Denmark
Effectiveness of Clonidine, Dexmedetomidine, and Fentanyl Adjuncts for Labor Epidural Analgesia
- Conditions
- Interventions
- First Posted Date
- 2022-08-04
- Last Posted Date
- 2023-10-10
- Lead Sponsor
- Grace Lim, MD, MS
- Target Recruit Count
- 88
- Registration Number
- NCT05487196
- Locations
- 🇺🇸
UPMC Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States
Treating Nightmares in Posttraumatic Stress Disorder With Clonidine and Doxazosin
- Conditions
- Interventions
- First Posted Date
- 2022-05-04
- Last Posted Date
- 2022-05-04
- Lead Sponsor
- Charite University, Berlin, Germany
- Target Recruit Count
- 189
- Registration Number
- NCT05360953
- Locations
- 🇩🇪
Berlin St. Hedwig, Berlin, Germany
🇩🇪Zentralinstitut für Seelische Gesundheit Mannheim, Mannheim, Germany
🇩🇪Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Klinik für Psychiatrie und Psychotherapie, Berlin, Germany
The Role of Stress Neuromodulators in Decision Making Under Risk (Part II)
- First Posted Date
- 2022-04-08
- Last Posted Date
- 2023-04-03
- Lead Sponsor
- Charite University, Berlin, Germany
- Target Recruit Count
- 82
- Registration Number
- NCT05318248
- Locations
- 🇩🇪
Charite University, Berlin, Germany
Drug Development Updates
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