Clonidine

Generic Name
Clonidine
Brand Names
Catapres, Catapres-TTS, Catapres-tts-1, Duraclon, Kapvay, Nexiclon XR
Drug Type
Small Molecule
Chemical Formula
C9H9Cl2N3
CAS Number
4205-90-7
Unique Ingredient Identifier
MN3L5RMN02
Background

Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.

Clonidine was granted FDA approval on 3 September 1974.

Indication

Clonidine tablets and transdermal systems are indicated for the treatment of hypertension alone or in combination with other medications. A clonidine injection is indicated for use with opiates in the treatment of severe cancer pain where opiates alone are insufficient. An extended release tablet of clonidine is indicated for the treatment of ADHD either alo...

Associated Conditions
Attention Deficit Hyperactivity Disorder (ADHD), Defiant Disorder, Oppositional, Gilles de la Tourette's Syndrome, Hot Flashes, Human Growth Hormone Deficiency, Hypertension, Opioid Withdrawal (Disorder), Pheochromocytoma, Postherpetic Neuralgia, Sialorrhea caused by clozapine, Diabetic diarrhea, Methadone withdrawal, Severe Cancer pain
Associated Therapies
Smoking, Cessation
Clinical Trials
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Dexmedetomidine Versus Clonidine for Transversus Abdominis Plane Block in Patients Undergoing Elective Caesarean Section

First Posted Date
2018-12-10
Last Posted Date
2020-08-05
Lead Sponsor
Aswan University Hospital
Target Recruit Count
150
Registration Number
NCT03770013
Locations
🇪🇬

Aswan University, Aswan, Egypt

Clonidine as Adjunct to Morphine for Neonatal Abstinence Syndrome

Phase 4
Terminated
Conditions
Neonatal Abstinence Syndrome
Interventions
Drug: Clonidine
Drug: Placebo
First Posted Date
2018-12-03
Last Posted Date
2023-02-10
Lead Sponsor
Hennepin County Medical Center, Minneapolis
Target Recruit Count
10
Registration Number
NCT03762317
Locations
🇺🇸

Hennepin County Medical Center, Minneapolis, Minnesota, United States

Premedication by Clonidine Intranasal in Pediatric Surgery

Phase 3
Conditions
Child Preschool
Interventions
Drug: Clonidine
Other: Placebo
First Posted Date
2018-10-31
Last Posted Date
2022-08-19
Lead Sponsor
University Hospital, Lille
Target Recruit Count
90
Registration Number
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Locations
🇫🇷

CHRU Lille, Lille, Nord, France

Prophylactic Mirtazapine or Clonidine for Post-spinal Anesthesia Shivering

Phase 4
Completed
Conditions
Shivering
Interventions
Drug: Placebo
Drug: Mirtazapine
Drug: Clonidine
First Posted Date
2018-09-20
Last Posted Date
2018-09-20
Lead Sponsor
Ain Shams University
Target Recruit Count
300
Registration Number
NCT03679052
Locations
🇪🇬

Ibrahim Mamdouh Esmat, Heliopolis, Cairo, Egypt

Clonidine Versus Phenobarbital as Adjunctive Therapy for Neonatal Abstinence Syndrome

First Posted Date
2018-09-13
Last Posted Date
2021-11-10
Lead Sponsor
University of Tennessee Medical Center
Target Recruit Count
25
Registration Number
NCT03670160
Locations
🇺🇸

University of Tennessee Medical Center, Knoxville, Tennessee, United States

Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial)

First Posted Date
2018-08-31
Last Posted Date
2024-10-03
Lead Sponsor
University of Edinburgh
Target Recruit Count
1437
Registration Number
NCT03653832
Locations
🇬🇧

Belfast Health & Social Care Trust, Belfast, United Kingdom

🇬🇧

South Eastern Health and Social Trust, Belfast, United Kingdom

🇬🇧

University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom

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Study of Clonidine Efficacy for the Treatment of Impulse Control Disorders in Parkinson's Disease:

First Posted Date
2018-06-11
Last Posted Date
2022-01-19
Lead Sponsor
Hospices Civils de Lyon
Target Recruit Count
38
Registration Number
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Locations
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Hospices Civils de Lyon, Bron, France

Sensorial and Physiological Mechanism-based Assessments of Perioperative Pain

Phase 3
Terminated
Conditions
Scoliosis
Interventions
Other: Morphine
Drug: Clonidine
First Posted Date
2018-05-25
Last Posted Date
2023-11-22
Lead Sponsor
Dr. Jean A. Ouellet, MD, FRCSC
Target Recruit Count
15
Registration Number
NCT03537612
Locations
🇨🇦

Shriners Hospitals for Children - Canada, Montréal, Quebec, Canada

Efficacy of Dexmedetomidine Versus Clonidine to Control Delirium in Patients Undergoing CABG

Not Applicable
Completed
Conditions
Delirium on Emergence
Interventions
Drug: Dexmedetomidine
Drug: Clonidine
First Posted Date
2018-03-27
Last Posted Date
2019-07-11
Lead Sponsor
Ain Shams University
Target Recruit Count
147
Registration Number
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Locations
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Ain Shams university, Cairo, Egypt

Non-Opiate Treatment After Prenatal Opiate Exposure to Prevent Postnatal Injury to the Young Brain

Phase 3
Completed
Conditions
Neonatal Abstinence Syndrome
Interventions
Drug: Clonidine
Drug: Morphine
First Posted Date
2018-01-11
Last Posted Date
2024-11-06
Lead Sponsor
Henrietta Bada
Target Recruit Count
120
Registration Number
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Kentucky Children's Hospital, Lexington, Kentucky, United States

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