Ivabradine
- Generic Name
- Ivabradine
- Brand Names
- Corlanor, Lancora, Procoralan, Corlentor, Ivabradine Accord, Ivabradine Anpharm, Ivabradine Zentiva
- Drug Type
- Small Molecule
- Chemical Formula
- C27H36N2O5
- CAS Number
- 155974-00-8
- Unique Ingredient Identifier
- 3H48L0LPZQ
- Background
Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus rhythm with resting heart rate ≥70 beats ...
- Indication
Ivabradine is indicated by the FDA to reduce the risk of hospitalization for worsening heart failure in adult patients with stable, symptomatic chronic heart failure with left ventricular ejection fraction ≤35%, who are in sinus rhythm with resting heart rate ≥70 beats per minute and either are on maximally tolerated doses of beta-blockers or have a contrain...
- Associated Conditions
- Chronic Heart Failure (CHF), Chronic Stable Angina Pectoris, Left Ventricular Dysfunction, Chronic, stable, symptomatic Heart Failure
- Associated Therapies
- -
Efficacy Study of Digoxin & Ivabradine to Treat Heart Failure
- First Posted Date
- 2012-10-04
- Last Posted Date
- 2013-11-11
- Lead Sponsor
- Cocco, Giuseppe, M.D.
- Target Recruit Count
- 22
- Registration Number
- NCT01699776
- Locations
- 🇨🇭
Cardiology office, Rheinfelden, Argovia, Switzerland
Ivabradine Versus Beta-blockers in the Treatment of Inappropriate Sinus Tachycardia
- Conditions
- Interventions
- First Posted Date
- 2012-08-06
- Last Posted Date
- 2016-09-30
- Lead Sponsor
- Policlinico Casilino ASL RMB
- Target Recruit Count
- 20
- Registration Number
- NCT01657136
- Locations
- 🇮🇹
Policlinico Casilino, Rome, Italy
Ischemia In Hemodialysed Patients: Ivabradine Versus Carvedilol
- Conditions
- Interventions
- First Posted Date
- 2011-08-29
- Last Posted Date
- 2012-06-28
- Lead Sponsor
- University of Campania "Luigi Vanvitelli"
- Target Recruit Count
- 220
- Registration Number
- NCT01425164
- Locations
- 🇮🇹
Chair of Cardiology Second University of Naples, Naples, Italy
Heart Failure With Normal Ejection Fraction (HFNEF) in Hemodialysed Patients: Beneficial Effect of Ivabradine
- First Posted Date
- 2011-06-15
- Last Posted Date
- 2012-01-19
- Lead Sponsor
- University of Campania "Luigi Vanvitelli"
- Target Recruit Count
- 150
- Registration Number
- NCT01373619
- Locations
- 🇮🇹
Chair of Cardiology Second Univesity of Naples, Naples, Italy
Ivabradine in Hemodialysed Patients With Increased Heart Rate
- First Posted Date
- 2011-06-02
- Last Posted Date
- 2012-06-21
- Lead Sponsor
- University of Campania "Luigi Vanvitelli"
- Target Recruit Count
- 100
- Registration Number
- NCT01364077
- Locations
- 🇮🇹
Chair of Cardiology, Naples, Italy
Reducing Elevated Heart Rate in Patients With Multiple Organ Dysfunction Syndrome (MODS) by Ivabradine
- First Posted Date
- 2010-08-23
- Last Posted Date
- 2010-09-08
- Lead Sponsor
- Martin-Luther-Universität Halle-Wittenberg
- Target Recruit Count
- 70
- Registration Number
- NCT01186783
- Locations
- 🇩🇪
Department of Medicine III of the University Clinics Halle (Saale) of the Martin-Luther-University Halle-Wittenberg, Halle (Saale), Saxony-Anhalt, Germany
Heart Rate Reduction in Heart Failure
- First Posted Date
- 2010-08-10
- Last Posted Date
- 2014-09-30
- Lead Sponsor
- IRCCS San Raffaele
- Target Recruit Count
- 121
- Registration Number
- NCT01178528
- Locations
- 🇮🇹
Centre for Clinical and Basic Research - IRCCS San Raffaele, Roma, Italy
🇮🇹IRCCS San Raffaele, Roma, Italy
Promotion of Coronary Collateral Function by Ivabradine-Induced Bradycardia in Patients With Coronary Artery Disease
- First Posted Date
- 2009-12-25
- Last Posted Date
- 2013-07-12
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 43
- Registration Number
- NCT01039389
- Locations
- 🇨🇭
Bern University Hospital, Bern, Switzerland
The Influence of Heart Rate Reduction Upon Central Arterial Pressure in Younger and Older Healthy Individuals
- First Posted Date
- 2009-12-09
- Last Posted Date
- 2011-11-09
- Lead Sponsor
- Bayside Health
- Target Recruit Count
- 42
- Registration Number
- NCT01029223
Effect of Ivabradine on Heart Rate & Effort Tolerance in Mitral Stenosis in Sinus Rhythm
- First Posted Date
- 2009-12-01
- Last Posted Date
- 2011-07-07
- Lead Sponsor
- Govind Ballabh Pant Hospital
- Target Recruit Count
- 50
- Registration Number
- NCT01022463
- Locations
- 🇮🇳
G. B. Pant Hospital, New Delhi, Delhi, India
Drug Development Updates
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