Ivabradine
- Generic Name
- Ivabradine
- Brand Names
- Corlanor, Lancora, Procoralan, Corlentor, Ivabradine Accord, Ivabradine Anpharm, Ivabradine Zentiva
- Drug Type
- Small Molecule
- Chemical Formula
- C27H36N2O5
- CAS Number
- 155974-00-8
- Unique Ingredient Identifier
- 3H48L0LPZQ
- Background
Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus rhythm with resting heart rate ≥70 beats ...
- Indication
Ivabradine is indicated by the FDA to reduce the risk of hospitalization for worsening heart failure in adult patients with stable, symptomatic chronic heart failure with left ventricular ejection fraction ≤35%, who are in sinus rhythm with resting heart rate ≥70 beats per minute and either are on maximally tolerated doses of beta-blockers or have a contrain...
- Associated Conditions
- Chronic Heart Failure (CHF), Chronic Stable Angina Pectoris, Left Ventricular Dysfunction, Chronic, stable, symptomatic Heart Failure
- Associated Therapies
- -
Effects of Heart Rate Reduction on Central Arterial Pressure in Healthy Individuals
- Conditions
- Interventions
- First Posted Date
- 2009-01-19
- Last Posted Date
- 2020-08-17
- Lead Sponsor
- Bayside Health
- Target Recruit Count
- 2
- Registration Number
- NCT00825123
- Locations
- 🇦🇺
The Alfred Hospital, Melbourne, Victoria, Australia
Effects of the Ivabradine on Reduction of Inflammatory Markers in Patients With Acute Coronary Syndrome
- First Posted Date
- 2008-12-29
- Last Posted Date
- 2020-08-11
- Lead Sponsor
- Hospital Universitario de Canarias
- Target Recruit Count
- 27
- Registration Number
- NCT00815100
- Locations
- 🇪🇸
Hospital Universitario de Canarias, La Laguna, Santa Cruz De Tenerife, Spain
If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure
- First Posted Date
- 2008-09-22
- Last Posted Date
- 2014-11-25
- Lead Sponsor
- St Vincent's University Hospital, Ireland
- Registration Number
- NCT00757055
- Locations
- 🇮🇪
Heart Failure Unit, St Michaels Hospital, Dublin, Ireland
Efficacy and Safety of Ivabradine on Top of Atenolol in Stable Angina Pectoris
- Conditions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2018-03-15
- Lead Sponsor
- Institut de Recherches Internationales Servier
- Target Recruit Count
- 750
- Registration Number
- NCT00202566
- Locations
- 🇨🇦
Montreal Heart Institute, Montreal, Quebec, Canada
Efficacy and Safety of Ivabradine in Severe Congestive Heart Failure
- Conditions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2024-07-25
- Lead Sponsor
- Institut de Recherches Internationales Servier
- Target Recruit Count
- 12
- Registration Number
- NCT00202579
- Locations
- 🇮🇹
Policlinico San Matteo, Pavia, Italy
The BEAUTIFUL Study: Effects of Ivabradine in Patients With Stable Coronary Artery Disease and Left Ventricular Systolic Dysfunction
- Conditions
- Interventions
- First Posted Date
- 2005-09-02
- Last Posted Date
- 2018-04-12
- Lead Sponsor
- Institut de Recherches Internationales Servier
- Target Recruit Count
- 10917
- Registration Number
- NCT00143507
- Locations
- 🇬🇧
Royal Brompton National Heart and Lung Hospital, London, United Kingdom
Drug Development Updates
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