Megestrol acetate
- Generic Name
- Megestrol acetate
- Brand Names
- Megace
- Drug Type
- Small Molecule
- Chemical Formula
- C24H32O4
- CAS Number
- 595-33-5
- Unique Ingredient Identifier
- TJ2M0FR8ES
- Background
17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
- Indication
For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used for the palliative management of recurrent, inoperable, or metastatic breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries.
- Associated Conditions
- Anorexia, Cachexia, Inoperable Carcinoma of Breast, Inoperable Endometrial Carcinoma, Metastatic Breast Carcinoma, Recurrent Breast Carcinoma, Recurrent Endometrial Carcinoma, Significant, Unexplained Weight Loss, Metastatic Endometrial carcinoma
- Associated Therapies
- Palliative Treatment
Comparison of Megestrol and/or Omega-3 Fatty Acid-Enriched Nutritional Supplement in Treating Patients With Cancer-Related Weight Loss and Lack of Appetite
- Conditions
- AnorexiaCachexia
- Interventions
- First Posted Date
- 2003-08-05
- Last Posted Date
- 2016-07-14
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Target Recruit Count
- 429
- Registration Number
- NCT00031707
- Locations
- 🇨🇦
Queen Elizabeth Hospital, PEI, Charlottetown, Prince Edward Island, Canada
🇨🇦Newfoundland Cancer Treatment and Research Foundation, St. Johns, Newfoundland and Labrador, Canada
🇺🇸Siouxland Hematology-Oncology, Sioux City, Iowa, United States
Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancer
- Conditions
- AnorexiaCachexiaHead and Neck CancerQuality of Life
- First Posted Date
- 2003-07-28
- Last Posted Date
- 2021-09-09
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 13
- Registration Number
- NCT00006799
- Locations
- 🇺🇸
Comprehensive Cancer Center at Wake Forest University, Winston-Salem, North Carolina, United States
Megestrol in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery
- Conditions
- Liver Cancer
- First Posted Date
- 2003-01-28
- Last Posted Date
- 2013-09-20
- Lead Sponsor
- National Medical Research Council (NMRC), Singapore
- Target Recruit Count
- 300
- Registration Number
- NCT00041275
- Locations
- 🇸🇬
Changi General Hospital, Singapore, Singapore
🇮🇩Rumah Sakit Sanglah, Denpasar, Bali, Indonesia
🇲🇲Yangon General Hospital, Yangon, Myanmar
A Study of Megestrol Acetate in HIV-Infected Children
- Conditions
- HIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Gamma Project - ACTU
- Target Recruit Count
- 25
- Registration Number
- NCT00002182
- Locations
- 🇵🇷
Univ of Puerto Rico / Med Science Campus, San Juan, Puerto Rico
A Phase I/II Study to Evaluate Single Agent and Combination Therapy With Megestrol Acetate and Dronabinol for the Treatment of HIV-Wasting Syndrome
- Conditions
- CachexiaHIV InfectionsHIV Wasting Syndrome
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2008-08-25
- Target Recruit Count
- 56
- Registration Number
- NCT00000737
- Locations
- 🇺🇸
Denver Public Health Dept, Denver, Colorado, United States
🇺🇸Univ of Illinois, Chicago, Illinois, United States
🇺🇸Univ of Kansas School of Medicine, Wichita, Kansas, United States
A Study Comparing Megestrol Acetate at 800 mg/Day, and Placebo in AIDS Patients With Anorexia and Cachexia
- Conditions
- CachexiaHIV InfectionsAnorexia
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2007-10-02
- Lead Sponsor
- Bristol-Myers Squibb
- Registration Number
- NCT00002067
- Locations
- 🇺🇸
Dr Mark Goldstein, Los Angeles, California, United States
🇺🇸Eisenhower Med Ctr, Rancho Mirage, California, United States
🇺🇸Northwestern Univ Med School, Chicago, Illinois, United States
A Study of Different Doses of Megestrol Acetate in Patients With AIDS Who Have Anorexia and Malnutrition
- Conditions
- AnorexiaCachexiaHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2007-10-02
- Lead Sponsor
- Bristol-Myers Squibb
- Registration Number
- NCT00002300
- Locations
- 🇺🇸
George Washington Univ Med Ctr, Washington, District of Columbia, United States
🇺🇸Denver Public Health Dept, Denver, Colorado, United States
🇺🇸Dr Stephen J Gabin Jr, Los Angeles, California, United States
The Safety and Effectiveness of Megace in HIV-Infected Women
- Conditions
- AnorexiaCachexiaHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2007-10-02
- Lead Sponsor
- Bristol-Myers Squibb
- Target Recruit Count
- 40
- Registration Number
- NCT00002345
- Locations
- 🇺🇸
Yale Univ Med School, New Haven, Connecticut, United States
🇺🇸Georgetown Univ Med Ctr, Washington, District of Columbia, United States
🇺🇸Univ of California - Davis Med Ctr / CARES, Sacramento, California, United States
A Study of Megestrol Acetate Alone or in Combination With Testosterone Enanthate Drug in the Treatment of HIV-Associated Weight Loss
- Conditions
- HIV Wasting SyndromeHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 80
- Registration Number
- NCT00001079
- Locations
- 🇺🇸
Memorial Sloan-Kettering Cancer Ctr., New York, New York, United States
🇺🇸USC CRS, Los Angeles, California, United States
🇺🇸UCLA CARE Center CRS, Los Angeles, California, United States
Drug Development Updates
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