Tromethamine

Generic Name: Tromethamine

Drug Type: Small Molecule

Chemical Formula: C_₄H_₁₁NO_₃

CAS Number: 77-86-1

Unique Ingredient Identifier: 023C2WHX2V

Background: An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)

Indication: For the prevention and correction of metabolic acidosis.

Associated Conditions: Metabolic Acidosis

Clinical Trials

Single Ascending Dose Safety and Tolerability of NTS-104 Healthy Adults

Phase 1

Recruiting

Conditions: Acute Ischemic Stroke

Interventions: Drug: Placebo
Drug: NTS-104 TRIS

First Posted Date: 2022-09-21

Last Posted Date: 2023-05-26

Lead Sponsor: NeuroTrauma Sciences, LLC

Target Recruit Count: 32

Registration Number: NCT05547438

Locations: 🇺🇸
Parexel International EPCU Baltimore 7th floor, Baltimore, Maryland, United States

MVA-BN-RSV Vaccine Trial

Phase 3

Terminated

Conditions: Respiratory Syncytial Virus Infections

Interventions: Biological: MVA-BN-RSV vaccine
Biological: Tris Buffered Saline (TBS)

First Posted Date: 2022-02-14

Last Posted Date: 2024-10-31

Lead Sponsor: Bavarian Nordic

Target Recruit Count: 20419

Registration Number: NCT05238025

Locations: 🇺🇸
Optimus U Corporation, Miami, Florida, United States
🇺🇸
De La Cruz Research Center, LLC, Miami, Florida, United States
🇺🇸
Great Lakes Clinical Trials at Ravenswood Rheumatology, Chicago, Illinois, United States

and more 109 locations

Atomized Intranasal Vs Intravenous Ketorolac in Acute Renal Colic Pain Management.

Phase 2

Completed

Conditions: Acute Renal Colic

Interventions: Drug: Intravenous Ketorolac Tromethamine
Drug: Intranasal Ketorolac Tromethamine

First Posted Date: 2020-06-22

Last Posted Date: 2022-02-08

Lead Sponsor: Oman Medical Speciality Board

Target Recruit Count: 171

Registration Number: NCT04441762

Locations: 🇴🇲
Sultan Qaboos University Hospital, Muscat, Aseeb, Oman

Intravenous Metoclopramide Versus Dexketoprofen Trometamol Versus Metoclopramide+ Dexketoprofen Trometamol in Migraine

Not Applicable

Completed

Conditions: Migraine

Interventions: Drug: dexketoprofen trometamol
Drug: metoclopramide+dexketoprofen trometamol
Drug: metoclopramide

First Posted Date: 2020-02-05

Last Posted Date: 2024-02-08

Lead Sponsor: Adiyaman University Research Hospital

Target Recruit Count: 150

Registration Number: NCT04252521

Locations: 🇹🇷
Adiyaman University Research Hospital, Adıyaman, Central, Turkey

Comparison of Drugs on Headache Treatment After ECT Treatment

Phase 4

Conditions: Mental Disorders

Interventions: Drug: Placebo
Drug: Deksketoprofen trometamol
Drug: Paracetamol

First Posted Date: 2019-02-05

Last Posted Date: 2019-02-05

Lead Sponsor: Mustafa Kemal University

Target Recruit Count: 225

Registration Number: NCT03830398

Locations: 🇹🇷
Mustafa Kemal University Medicine Faculty Anesthesiology Department, Hatay, Turkey

Airway Alkalinization and Nasal Colonization

Phase 1

Completed

Conditions: Healthy Subjects
Cystic Fibrosis

Interventions: Drug: Saline
Drug: Tham

First Posted Date: 2017-03-13

Last Posted Date: 2020-03-30

Lead Sponsor: Lakshmi Durairaj

Target Recruit Count: 32

Registration Number: NCT03078088

Locations: 🇺🇸
Univeristy of IOwa, Iowa City, Iowa, United States

Study of Metatinib Tromethamine Tablet

Phase 1

Conditions: Advanced or Metastatic CRC
Advanced or Metastatic Liver Cancer
Advanced or Metastatic Non Squamous NSCLC
Advanced or Metastatic Gastric Cancer

Interventions: Drug: Metatinib Tromethamine

First Posted Date: 2016-01-08

Last Posted Date: 2017-01-23

Lead Sponsor: Jiangsu Simcere Pharmaceutical Co., Ltd.

Target Recruit Count: 24

Registration Number: NCT02650375

Locations: 🇨🇳
The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China
🇨🇳
The First Bethune Hospital of Jilin University, Changchun, Jilin, China
🇨🇳
West China Hospital, Sichuan University, Chengdu, Sichuan, China

Effect of Morphine, Tramadol, and Ketorolac on Postoperative Stress and Immune Responses

Phase 2

Conditions: Breast Cancer

Interventions: Drug: Intravenous tramadol HCL
Drug: Intravenous morphine sulphate
Drug: Intravenous ketorolac tromethamine

First Posted Date: 2015-05-21

Last Posted Date: 2015-05-21

Lead Sponsor: Assiut University

Target Recruit Count: 60

Registration Number: NCT02449954

Phase I Clinical Study of Metatinib Tromethamine Tablet

Phase 1

Completed

Conditions: Advanced or Metastatic Solid Tumors

Interventions: Drug: Metatinib Tromethamine

First Posted Date: 2013-12-09

Last Posted Date: 2015-12-29

Lead Sponsor: Jiangsu Simcere Pharmaceutical Co., Ltd.

Target Recruit Count: 18

Registration Number: NCT02004548

Locations: 🇨🇳
West China Hospital, Sichuan University, Chengdu, Sichuan, China

Safety and Efficacy of Multiple Doses of Intranasal Ketorolac in Postoperative Pain Following Major Abdominal Surgery

Phase 3

Completed

Conditions: Postoperative Pain

Interventions: Drug: Intranasal Ketorolac Tromethamine
Drug: Intranasal Placebo

First Posted Date: 2005-12-19

Last Posted Date: 2017-02-08

Lead Sponsor: Egalet Ltd

Target Recruit Count: 321

Registration Number: NCT00266786

Locations: 🇺🇸
Methodist Hospital, Arcadia, California, United States
🇺🇸
Glendale Adventist Medical Center, Glendale, California, United States
🇳🇿
Waikato Clinical Research, Hamilton, New Zealand

and more 3 locations

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