Diphenhydramine

Generic Name: Diphenhydramine

Brand Names: Acetadryl, Advil PM, Aleve PM, Allegra Cooling Relief Anti-itch, Banophen, Benadryl, Benadryl Itch Stopping, Benadryl-D Allergy and Sinus, Calagel, Damylin With Codeine, Dimetapp Nighttime Cold & Congestion, Diphen, Diphenhist, Diphenist, Excedrin PM Triple Action, Goody's PM, Legatrin PM, Motrin PM, Nytol, Nytol Quickgels, Percogesic Reformulated Jan 2011, Siladryl, Simply Sleep, Sleepinal, Sominex, Triaminic Night Time Cold & Cough, Tylenol PM, Unisom, Unisom Sleep, Vanamine, Wal-dryl, Wal-som (doxylamine), Zzzquil

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₁NO

CAS Number: 58-73-1

Unique Ingredient Identifier: 8GTS82S83M

Background: Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes . However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties . As histamine receptors exist both ...

Indication: Diphenhydramine is a first-generation histamine H1 receptor antagonist (H1 antihistamine) that is widely available as a non-prescription, over-the-counter (OTC) medication. As an OTC medication, diphenhydramine is typically formulated as tablets and creams indicated for use in treating sneezing, runny nose, itchy/watery eyes, itching of nose or throat, insom...

Associated Conditions: Allergic Reaction, Allergic Rhinitis (AR), Allergic cough, Allergy to Tree Pollen, Anaphylaxis, Angioedema, Common Cold, Conjunctival irritation, Cough, Cough Variant Asthma, Cough caused by Common Cold, Eye allergy, Fever, Insect Bites, Insect Stings, Insomnia, Irritative cough, Itching of the nose, Itching of the throat, Motion Sickness, Nasal Congestion, Oral Mucositis, Pain, Parkinsonian Syndromes, Productive cough, Pruritus, Rash, Rhinorrhoea, Sinus Congestion, Sinus headache, Skin Irritation, Sneezing, Sunburn, Symptoms of Acute Bronchitis Accompanied by Coughing, Upper respiratory tract hypersensitivity reaction, site unspecified, Urticaria, Cold or flu syndrome, Dermatographism, Dry cough, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Expectorant

Clinical Trials

Histamine Glutamate Antagonism in Stroke

Phase 2

Completed

Conditions: Acute Cerebrovascular Accident
Cerebral Edema

Interventions: Drug: Pantoprazole
Drug: Diphenhydramine
Drug: Famotidine
Drug: Dextromethorphan

First Posted Date: 2014-05-20

Last Posted Date: 2015-12-15

Lead Sponsor: University of Florida

Target Recruit Count: 3

Registration Number: NCT02142712

Locations: 🇺🇸
Shands Hospital at University of Florida, Gainesville, Florida, United States

Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department Patients

Phase 2

Completed

Conditions: Depression

Interventions: Drug: Ketamine
Drug: Diphenhydramine

First Posted Date: 2014-04-08

Last Posted Date: 2018-09-14

Lead Sponsor: NYU Langone Health

Target Recruit Count: 21

Registration Number: NCT02106325

Locations: 🇺🇸
Bellevue Hospital Center, New York, New York, United States
🇺🇸
NYU Langone Medical Center/Tisch Hospital, New York, New York, United States

Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the Emergency Department: A Randomized Controlled Trial

Phase 4

Completed

Conditions: Migraine Headaches
Nausea
Restlessness

Interventions: Drug: Metoclopramide 10mg
Drug: Haloperidol
Drug: Diphenhydramine

First Posted Date: 2014-03-28

Last Posted Date: 2014-03-28

Lead Sponsor: United States Naval Medical Center, Portsmouth

Target Recruit Count: 68

Registration Number: NCT02098499

Locations: 🇺🇸
Naval Medical Center Portsmouth, Portsmouth, Virginia, United States

A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence

Phase 2

Completed

Conditions: Alcohol Dependence

Interventions: Drug: Diphenhydramine
Drug: Psilocybin
Behavioral: Motivational Enhancement and Taking Action (META)

First Posted Date: 2014-02-12

Last Posted Date: 2022-11-08

Lead Sponsor: NYU Langone Health

Target Recruit Count: 95

Registration Number: NCT02061293

Locations: 🇺🇸
Clinical and Translational Science Institute, NYU Langone Medical Center, New York, New York, United States
🇺🇸
University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States

Psilocybin-facilitated Treatment for Cocaine Use

Phase 2

Completed

Conditions: Cocaine-Related Disorders

Interventions: Drug: Psilocybin
Drug: Diphenhydramine

First Posted Date: 2014-01-15

Last Posted Date: 2024-10-24

Lead Sponsor: University of Alabama at Birmingham

Target Recruit Count: 40

Registration Number: NCT02037126

Locations: 🇺🇸
UAB Outpatient Clinical Research Unit, Birmingham, Alabama, United States

BMT and High Dose Post-Transplant Cyclophosphamide for Chimerism Induction and Renal Allograft Tolerance

Phase 2

Terminated

Conditions: Kidney Transplantation

Interventions: Biological: anti-thymocyte globulin
Drug: Fludarabine
Drug: Cyclophosphamide
Radiation: Total Body Irradiation
Drug: acetaminophen
Drug: diphenhydramine
Drug: methylprednisolone
Biological: bone marrow transplant
Drug: MESNA
Drug: mycophenolate mofetil
Drug: prednisone
Drug: filgrastim

First Posted Date: 2014-01-08

Last Posted Date: 2018-09-24

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 4

Registration Number: NCT02029638

Locations: 🇺🇸
Johns Hopkins University, Baltimore, Maryland, United States

Pilot Phase III Clinical Trial of JDP-205 IV Injection for Treatment of Acute Urticaria

Phase 3

Completed

Conditions: Acute Urticaria

Interventions: Drug: JDP-205 Injection
Drug: Diphenhydramine

First Posted Date: 2013-12-30

Last Posted Date: 2024-02-09

Lead Sponsor: JDP Therapeutics, Inc.

Target Recruit Count: 36

Registration Number: NCT02023164

Locations: 🇨🇦
Del Carpio Independent Practice, Montréal, Quebec, Canada
🇨🇦
Glengarry Memorial Hospital, Independent Practice, Alexandria, Ontario, Canada
🇺🇸
OSU Hospitals, Department of Emergency Medicine, Columbus, Ohio, United States

and more 3 locations