Diphenhydramine
- Generic Name
- Diphenhydramine
- Brand Names
- Acetadryl, Advil PM, Aleve PM, Allegra Cooling Relief Anti-itch, Banophen, Benadryl, Benadryl Itch Stopping, Benadryl-D Allergy and Sinus, Calagel, Damylin With Codeine, Dimetapp Nighttime Cold & Congestion, Diphen, Diphenhist, Diphenist, Excedrin PM Triple Action, Goody's PM, Legatrin PM, Motrin PM, Nytol, Nytol Quickgels, Percogesic Reformulated Jan 2011, Siladryl, Simply Sleep, Sleepinal, Sominex, Triaminic Night Time Cold & Cough, Tylenol PM, Unisom, Unisom Sleep, Vanamine, Wal-dryl, Wal-som (doxylamine), Zzzquil
- Drug Type
- Small Molecule
- Chemical Formula
- C17H21NO
- CAS Number
- 58-73-1
- Unique Ingredient Identifier
- 8GTS82S83M
- Background
Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes . However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties . As histamine receptors exist both ...
- Indication
Diphenhydramine is a first-generation histamine H1 receptor antagonist (H1 antihistamine) that is widely available as a non-prescription, over-the-counter (OTC) medication. As an OTC medication, diphenhydramine is typically formulated as tablets and creams indicated for use in treating sneezing, runny nose, itchy/watery eyes, itching of nose or throat, insom...
- Associated Conditions
- Allergic Reaction, Allergic Rhinitis (AR), Allergic cough, Allergy to Tree Pollen, Anaphylaxis, Angioedema, Common Cold, Conjunctival irritation, Cough, Cough Variant Asthma, Cough caused by Common Cold, Eye allergy, Fever, Insect Bites, Insect Stings, Insomnia, Irritative cough, Itching of the nose, Itching of the throat, Motion Sickness, Nasal Congestion, Oral Mucositis, Pain, Parkinsonian Syndromes, Productive cough, Pruritus, Rash, Rhinorrhoea, Sinus Congestion, Sinus headache, Skin Irritation, Sneezing, Sunburn, Symptoms of Acute Bronchitis Accompanied by Coughing, Upper respiratory tract hypersensitivity reaction, site unspecified, Urticaria, Cold or flu syndrome, Dermatographism, Dry cough, Watery itchy eyes
- Associated Therapies
- Airway secretion clearance therapy, Expectorant
Abatacept for GVHD Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell Disease
- Conditions
- Interventions
- First Posted Date
- 2016-08-16
- Last Posted Date
- 2024-06-13
- Lead Sponsor
- Monica Bhatia
- Target Recruit Count
- 24
- Registration Number
- NCT02867800
- Locations
- 🇺🇸
North Carolina Cancer Hospital, Chapel Hill, North Carolina, United States
🇺🇸Columbia University Irving Medical Center, New York, New York, United States
🇺🇸Children's National Medical Center, Washington, District of Columbia, United States
Treg Therapy in Subclinical Inflammation in Kidney Transplantation
- Conditions
- Interventions
- First Posted Date
- 2016-03-17
- Last Posted Date
- 2024-10-07
- Target Recruit Count
- 32
- Registration Number
- NCT02711826
- Locations
- 🇺🇸
University of California at San Francisco, San Francisco, California, United States
🇺🇸University of Alabama, Birmingham, Birmingham, Alabama, United States
🇺🇸University of Colorado Health Transplant Center - Anschutz, Aurora, Colorado, United States
The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine
- Conditions
- Interventions
- First Posted Date
- 2016-01-15
- Last Posted Date
- 2017-12-11
- Lead Sponsor
- University Medical Center of Southern Nevada
- Target Recruit Count
- 54
- Registration Number
- NCT02657031
- Locations
- 🇺🇸
University Medical Center of Southern Nevada, Las Vegas, Nevada, United States
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
- Conditions
- Interventions
- First Posted Date
- 2016-01-14
- Last Posted Date
- 2021-07-02
- Lead Sponsor
- University of Washington
- Target Recruit Count
- 635
- Registration Number
- NCT02655354
- Locations
- 🇺🇸
Jacobi Medical Center, Bronx, New York, United States
🇺🇸University of Rochester, Rochester, New York, United States
🇺🇸Honor Health, Scottsdale, Arizona, United States
An Open-label, Phase 1 Study to Determine the Maximum Tolerated Dose of HLX07,in Patients With Advanced Solid Cancers
- Conditions
- Interventions
- First Posted Date
- 2016-01-07
- Last Posted Date
- 2019-07-30
- Lead Sponsor
- Henlix, Inc
- Target Recruit Count
- 19
- Registration Number
- NCT02648490
- Locations
- 🇺🇸
Henlix, Inc., Fremont, California, United States
🇨🇳Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan
A Study of ARC-520 at Varying Infusion Rates in Healthy Adult Volunteers
- First Posted Date
- 2015-08-28
- Last Posted Date
- 2018-02-26
- Lead Sponsor
- Arrowhead Pharmaceuticals
- Target Recruit Count
- 40
- Registration Number
- NCT02535416
- Locations
- 🇦🇺
QPharm, Pty Limited, Royal Brisbane Hospital, Herston, Queensland, Australia
Effects of Inhibiting Early Inflammation in Kidney Transplant Patients
- First Posted Date
- 2015-07-13
- Last Posted Date
- 2022-08-16
- Target Recruit Count
- 290
- Registration Number
- NCT02495077
- Locations
- 🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States
🇺🇸University of Maryland, Baltimore, Maryland, United States
🇺🇸University of California, Los Angeles, Los Angeles, California, United States
A Safety, Efficacy and Biomarker Study of JNJ-42847922 in Participants With Major Depressive Disorder
- Conditions
- Interventions
- First Posted Date
- 2015-06-19
- Last Posted Date
- 2023-01-05
- Lead Sponsor
- Janssen-Cilag International NV
- Target Recruit Count
- 48
- Registration Number
- NCT02476058
Donor Alloantigen Reactive Tregs (darTregs) for Calcineurin Inhibitor (CNI) Reduction
- First Posted Date
- 2015-06-17
- Last Posted Date
- 2021-02-09
- Target Recruit Count
- 15
- Registration Number
- NCT02474199
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
🇺🇸University of California at San Francisco, San Francisco, California, United States
🇺🇸Northwestern University Comprehensive Transplant Ctr, Chicago, Illinois, United States
Dyphenhidramine Effect on Prevention of Sevoflurane Induced Post Anesthesia Agitation in Pediatric
- Conditions
- Interventions
- First Posted Date
- 2015-06-04
- Last Posted Date
- 2015-06-04
- Lead Sponsor
- Universitas Diponegoro
- Target Recruit Count
- 50
- Registration Number
- NCT02463929
Drug Development Updates
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