Desipramine

Generic Name: Desipramine

Brand Names: Norpramin

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₂N_₂

CAS Number: 50-47-5

Unique Ingredient Identifier: TG537D343B

Background: Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipram...

Indication: For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management.

Associated Conditions: Anorexia Nervosa (AN), Bulimia Nervosa, Chronic Pain, Depression, Diabetic Neuropathies, Insomnia, Irritable Bowel Syndrome (IBS), Neuropathic Pain, Panic Disorder, Postherpetic Neuralgia

Associated Therapies: -

Clinical Trials

Pre-Treatment Positron Emission Topography Scanning for Increasing Success in Antidepressant Treatment

Not Applicable

Completed

Conditions: Depression

Interventions: Drug: Escitalopram
Drug: Desipramine

First Posted Date: 2007-04-04

Last Posted Date: 2019-03-19

Lead Sponsor: New York State Psychiatric Institute

Target Recruit Count: 37

Registration Number: NCT00456014

Locations: 🇺🇸
Columbia University/New York State Psychiatric Institute, New York, New York, United States

Study Evaluating the Effects of DVS SR and Duloxetine on the Pharmacokinetics of Desipramine in Healthy Subjects

Phase 3

Completed

Conditions: Depression
Depressive Disorder
Depressive Disorder, Major

First Posted Date: 2006-08-21

Last Posted Date: 2007-05-28

Lead Sponsor: Wyeth is now a wholly owned subsidiary of Pfizer

Target Recruit Count: 20

Registration Number: NCT00366652

Naltrexone & SSRI in Alcoholics With Depression/PTSD

Phase 3

Completed

Conditions: Alcoholism
Depression
PTSD

Interventions: Drug: paroxetine
Drug: desipramine
Drug: Placebo
Drug: Naltrexone

First Posted Date: 2006-06-20

Last Posted Date: 2016-02-05

Lead Sponsor: Yale University

Target Recruit Count: 88

Registration Number: NCT00338962

Locations: 🇺🇸
VA Connecticut Healthcare Systems, West Haven, Connecticut, United States

Study Evaluating the Effects of DVS SR and Paroxetine on the Pharmacokinetics of Desipramine in Healthy Subjects

Phase 3

Completed

Conditions: Depression

First Posted Date: 2006-05-24

Last Posted Date: 2007-12-07

Lead Sponsor: Wyeth is now a wholly owned subsidiary of Pfizer

Target Recruit Count: 20

Registration Number: NCT00329147

Desipramine for Improving Cellular Signaling and Decreasing Symptoms of Major Depression

Phase 4

Completed

Conditions: Depression

First Posted Date: 2006-05-03

Last Posted Date: 2015-08-19

Lead Sponsor: Harvard Medical School (HMS and HSDM)

Target Recruit Count: 43

Registration Number: NCT00320632

Locations: 🇺🇸
Massachusetts Mental Health Center, Boston, Massachusetts, United States

Tricyclic Antidepressants (TCAs) on Gastric Emptying

Not Applicable

Terminated

Conditions: Dyspepsia

Interventions: Drug: Amitriptyline
Drug: Desipramine

First Posted Date: 2005-09-22

Last Posted Date: 2021-03-05

Lead Sponsor: Temple University

Target Recruit Count: 10

Registration Number: NCT00220844

Locations: 🇺🇸
Temple University School of Medicine, Philadelphia, Pennsylvania, United States

Depression, Epinephrine, and Platelet Function

Phase 4

Completed

Conditions: Major Depressive Disorder

Interventions: Drug: Desipramine
Drug: Escitalopram

First Posted Date: 2005-09-14

Last Posted Date: 2015-07-23

Lead Sponsor: Emory University

Target Recruit Count: 40

Registration Number: NCT00166114

Locations: 🇺🇸
Emory University School of Medicine, Atlanta, Georgia, United States

Effect of Antidepressants on Back Pain

Phase 2

Completed

Conditions: Back Pain
Sciatica

Interventions: Drug: Benztropine
Drug: Desipramine
Drug: Fluoxetine

First Posted Date: 2001-07-05

Last Posted Date: 2012-06-05

Lead Sponsor: US Department of Veterans Affairs

Target Recruit Count: 130

Registration Number: NCT00018200

Locations: 🇺🇸
VA San Diego Healthcare System, San Diego, San Diego, California, United States

Biological Aspects of Depression and Antidepressant Drugs

Not Applicable

Completed

Conditions: Depression

First Posted Date: 2001-07-05

Last Posted Date: 2009-01-21

Lead Sponsor: US Department of Veterans Affairs

Registration Number: NCT00018733

Locations: 🇺🇸
South Texas Veterans Health Care System, San Antonio, Texas, United States

Treatment of Functional Bowel Disorders

Phase 3

Completed

Conditions: Irritable Bowel Syndrome
Constipation
Abdominal Pain
Functional Colonic Diseases

First Posted Date: 2000-08-09

Last Posted Date: 2010-01-13

Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Target Recruit Count: 300

Registration Number: NCT00006157

Locations: 🇺🇸
UNC Center for Functional GI Motility Disorders, Chapel Hill, North Carolina, United States
🇨🇦
Centre for Addiction and Mental Health, Clark Site, Toronto, Ontario, Canada

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

Home Terms & Conditions Privacy Policy