Desipramine
- Generic Name
- Desipramine
- Brand Names
- Norpramin
- Drug Type
- Small Molecule
- Chemical Formula
- C18H22N2
- CAS Number
- 50-47-5
- Unique Ingredient Identifier
- TG537D343B
- Background
Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipram...
- Indication
For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management.
- Associated Conditions
- Anorexia Nervosa (AN), Bulimia Nervosa, Chronic Pain, Depression, Diabetic Neuropathies, Insomnia, Irritable Bowel Syndrome (IBS), Neuropathic Pain, Panic Disorder, Postherpetic Neuralgia
- Associated Therapies
- -
Desipramine in Infantile Neuroaxonal Dystrophy (INAD).
- First Posted Date
- 2018-11-01
- Last Posted Date
- 2020-10-14
- Lead Sponsor
- Duke University
- Target Recruit Count
- 4
- Registration Number
- NCT03726996
- Locations
- 🇺🇸
Duke University Health Center, Durham, North Carolina, United States
Comparing Effectiveness of Duloxetine and Desipramine in Patients With Chronic Pain: A Pragmatic Trial Using Point of Care Randomization
- First Posted Date
- 2018-06-07
- Last Posted Date
- 2024-11-22
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 320
- Registration Number
- NCT03548454
- Locations
- 🇺🇸
Stanford Pain Management Center, Redwood City, California, United States
Effect of Desipramine on Upper Airway Collapsibility and Genioglossus Muscle Activity in Patients With Obstructive Sleep Apnea - Study B
- First Posted Date
- 2015-05-06
- Last Posted Date
- 2017-03-30
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 16
- Registration Number
- NCT02436031
- Locations
- 🇺🇸
Sleep Disorders Research Program Brigham and Women's Hospital, Boston, Massachusetts, United States
Effect of Desipramine on Genioglossus Muscle Activity in Healthy Adults Study A
- First Posted Date
- 2015-04-28
- Last Posted Date
- 2017-03-30
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 17
- Registration Number
- NCT02428478
- Locations
- 🇺🇸
Sleep Disorders Research Program Brigham and Women's Hospital, Boston, Massachusetts, United States
To Evaluate the Effect of Mirabegron (YM178) on Blood Levels of Desipramine When They Are Taken Together
- Conditions
- Interventions
- First Posted Date
- 2011-11-23
- Last Posted Date
- 2014-04-10
- Lead Sponsor
- Astellas Pharma Inc
- Target Recruit Count
- 28
- Registration Number
- NCT01478568
- Locations
- 🇫🇷
SGS Aster, Paris, France
Compare the Pharmacokinetics of Omeprazole, Rosiglitazone, and Desipramine When Administered With Avanafil in Healthy Male Subjects
- Conditions
- Interventions
- First Posted Date
- 2011-08-11
- Last Posted Date
- 2011-08-11
- Lead Sponsor
- VIVUS LLC
- Target Recruit Count
- 60
- Registration Number
- NCT01415128
A Drug Interaction Study to Assess the Effect of LY2603618 on the Metabolic Pathway of Desipramine
- Conditions
- Interventions
- First Posted Date
- 2011-05-24
- Last Posted Date
- 2018-10-25
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 20
- Registration Number
- NCT01358968
- Locations
- 🇺🇸
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Memphis, Tennessee, United States
A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors
- Conditions
- Interventions
- First Posted Date
- 2010-12-23
- Last Posted Date
- 2020-01-22
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 366
- Registration Number
- NCT01265550
- Locations
- 🇺🇸
Birmingham VA Medical Center, Birmingham, AL, Birmingham, Alabama, United States
🇺🇸VA Loma Linda Healthcare System, Loma Linda, CA, Loma Linda, California, United States
🇺🇸VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts, United States
Irritable Bowel Syndrome (IBS) Functional Magnetic Resonance Imaging (fMRI) With Desipramine
- First Posted Date
- 2009-04-14
- Last Posted Date
- 2022-08-31
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 70
- Registration Number
- NCT00880594
- Locations
- 🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States
Study Evaluating the Pharmacokinetics of the Potential Drug Interaction Between HCV-796 and Desipramine
- Conditions
- First Posted Date
- 2007-07-13
- Last Posted Date
- 2008-04-14
- Lead Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
- Target Recruit Count
- 22
- Registration Number
- NCT00500721
Drug Development Updates
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