Desipramine
- Generic Name
- Desipramine
- Brand Names
- Norpramin
- Drug Type
- Small Molecule
- Chemical Formula
- C18H22N2
- CAS Number
- 50-47-5
- Unique Ingredient Identifier
- TG537D343B
- Background
Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipram...
- Indication
For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management.
- Associated Conditions
- Anorexia Nervosa (AN), Bulimia Nervosa, Chronic Pain, Depression, Diabetic Neuropathies, Insomnia, Irritable Bowel Syndrome (IBS), Neuropathic Pain, Panic Disorder, Postherpetic Neuralgia
- Associated Therapies
- -
Cognitive and Drug Therapy for Drug-Resistant Depression
- Conditions
- First Posted Date
- 1999-11-03
- Last Posted Date
- 2015-10-12
- Lead Sponsor
- University of Pennsylvania
- Registration Number
- NCT00000376
Phase III Randomized Controlled Study of Morphine and Nortriptyline in the Management of Postherpetic Neuralgia
- Conditions
- First Posted Date
- 1999-10-19
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Target Recruit Count
- 120
- Registration Number
- NCT00004390
Methamphetamine Abuse Treatment in Patients With AIDS - 1
- Conditions
- First Posted Date
- 1999-09-21
- Last Posted Date
- 2017-01-12
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Registration Number
- NCT00000321
- Locations
- 🇺🇸
Friends Research Institute, Los Angeles, California, United States
New Approaches to Cocaine Abuse Medications (A) - 6
- Conditions
- Interventions
- First Posted Date
- 1999-09-21
- Last Posted Date
- 2017-07-05
- Lead Sponsor
- New York State Psychiatric Institute
- Target Recruit Count
- 111
- Registration Number
- NCT00000271
- Locations
- 🇺🇸
Research Foundation for Mental Hygiene, New York, New York, United States
Evaluation of a Desipramine Ceiling in Cocaine Abuse - 1
- Conditions
- First Posted Date
- 1999-09-21
- Last Posted Date
- 2017-01-12
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Registration Number
- NCT00000245
- Locations
- 🇺🇸
Friends Research Institute, Los Angeles, California, United States
IV Cocaine Abuse: A Laboratory Model - 1
- Conditions
- First Posted Date
- 1999-09-21
- Last Posted Date
- 2015-08-31
- Lead Sponsor
- New York State Psychiatric Institute
- Registration Number
- NCT00000212
- Locations
- 🇺🇸
Columbia University, New York, New York, United States
Drug Development Updates
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